TY  - JOUR
T1  - Langerhans Cell Histiocytosis In Bone: A Case Report
AU  - Buluz, Özlem
AU  - Kutlu, Orkide
AU  - Meral, Gizem
AU  - Eruzun, Hasan
AU  - Kutlu, Ayça Zeynep
AU  - Çelik, Suat Erol
PY  - 2021
DA  - October
Y2  - 2021
DO  - 10.46310/tjim.876279
JF  - Turkish Journal of Internal Medicine
JO  - Turk J Int Med
PB  - Nizameddin KOCA
WT  - DergiPark
SN  - 2687-4245
SP  - 201
EP  - 206
VL  - 3
IS  - 4
LA  - en
AB  - Langerhans cell histiocytosis (LCH) is a rare disease in which histiocytic infiltrations can be seen in bone, skin, lymph nodes, lungs, liver, spleen, bone marrow, central nervous system and endocrine glands.  Pulmonary LCH has been closely associated with smoking while there is no data on genetic, viral or neoplastic etiology.   In LCH with multiple system involvement, unifocal/multifocal infiltrations occur in two or more organs together with systemic symptoms such as weight loss and fever. In histology, Langerhans cells that do not contain phagocytic material in their cytoplasm, have a folded "coffee bean" appearance in their nucleus, express histiocyte markers CD1a, S100 and C207 and contain Birbeck granules under electron microscope. In treatment, if there is a risk of collapse in spinal or femoral bone lesions, surgery and radiotherapy can be applied for stabilization; if necessary, chemotherapy can be applied in multisystem disease. Here, we reported a LCH patient with a  malignant shaped lytic lesion in the thoracic spine and adjacent bone.
KW  - Langerhans Cell Histiocytosis
KW  - Histiocytosis In Bone
KW  - Histiocytosis
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UR  - https://doi.org/10.46310/tjim.876279
L1  - https://dergipark.org.tr/en/download/article-file/1562705
ER  -