@article{article_879204, title={Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers}, journal={Experimed}, volume={11}, pages={27–32}, year={2021}, DOI={10.26650/experimed.2021.879204}, author={Ertik, Onur and Sacan, Ozlem and Kabasakal, Levent and Şener, Göksel and Yanardağ, Refiye}, keywords={Diabetes, Chard, Liver, Glycoprotein}, abstract={<p>Objective: Diabetes mellitus is a metabolic disease of global im-portance. It affects many people by reducing their quality of life and even causing death. Therefore, research on diabetes mellitus maintains its popularity and continues to develop. Chard (Beta vulgaris L. var. cicla) is commonly used in diets and is known to have alternative hypoglycemic effects in diabetic individuals. This study investigated the protective effects of chard on glycoproteins (hexose, hexosamine, fucose and sialic acid) and the advanced ox-idation protein product levels in diabetic rats’ livers. </p> <p>Materials and Methods: For this experiment, male Sprague–Daw-ley rats were separated into three groups: the control; Streptozoto-cin (STZ)-induced diabetic rats; and STZ-induced diabetic + chard extract. Fourteen days after diabetes induction, chard extract (2 g/kg/day, gavage) was administered for 45 days. On day 60, liver samples were collected, and 10% (w/v) homogenate was prepared for the analysis of glycoprotein components and advanced oxida-tion protein products. </p> <p>Results: Levels of glycoprotein parameters that include hexose, hexosamine, fucose, and sialic acid, as well as advanced oxidation protein product levels, increased in the diabetic group. Chard ex-tract administration curatively reverted the altered biochemical parameters. </p> <p>Conclusion: From the results obtained, it can be suggested that chard extract has a protective effect on the diabetic livers of rats. </p>}, number={1}, publisher={Istanbul University}, organization={İstanbul Üniversitesi/İstanbul Üniversitesi-Cerrahpaşa}