TY - JOUR T1 - Expanding the discussion on fibrinolytic contraindications AU - Özdemir, Serdar AU - Sönmez, Ertan AU - Gülen, Bedia AU - Taslidere, Bahadir AU - Özcan, Ayşe Büşra PY - 2021 DA - October Y2 - 2021 JF - Deneysel ve Klinik Tıp Dergisi JO - J. Exp. Clin. Med. PB - Ondokuz Mayıs University WT - DergiPark SN - 1309-4483 SP - 672 EP - 674 VL - 38 IS - 4 LA - en AB - The European Resuscitation Council Guidelines recommend the administration of fibrinolytic therapy when acute pulmonary embolism is a known or suspected cause of cardiac arrest. However, contraindications that limit the use of fibrinolytics are sometimes challenged by clinicians, including head trauma in the previous three weeks. We report on the successful use of rescue fibrinolytic therapy on a patient with acute head trauma who had a cardiac arrest in the emergency department as a result of a pulmonary embolism (PE). To the best of our knowledge, this is the first case of successful fibrinolytic therapy for a patient with acute head trauma in the literature. KW - Thrombolytic Therapy KW - Fibrinolytic Agents KW - Pulmonary Embolism KW - embolism CR - 1. Link MS, Berkow LC, Kudenchuk PJ, et al. Part 7: adult advanced cardiovascular life support: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132(18_suppl_2):S444-S464. CR - 2. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). The European Respiratory Journal. 2019 Sep;54(3). DOI: 10.1183/13993003.01647-2019. CR - 3. Duru S, Keleşoğlu A, Ardıç S. Clinical update on pulmonary embolism. Arch Med Sci. 2014;10(3):557. CR - 4. Caballero A, Magaldi M, Pujol R, et al. Survival in cardiopulmonary resuscitation due to massive pulmonary embolism: A case series in a tertiary hospital. Resuscitation. 2017;118:e14. CR - 5. Members ATF, Konstantinides SV, Torbicki A, et al. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) Endorsed by the European Respiratory Society (ERS). European heart journal. 2014;35(43):3033-3080. CR - 6. Kanter DS, Mikkola KM, Patel SR, Parker JA, Goldhaber SZ. Thrombolytic therapy for pulmonary embolism: frequency of intracranial hemorrhage and associated risk factors. Chest. 1997;111(5):1241-1245. CR - 7. Mikkola KM, Patel SR, Parker JA, Grodstein F, Goldhaber SZ. Increasing age is a major risk factor for hemorrhagic complications after pulmonary embolism thrombolysis. Am Heart J. 1997;134(1):69-72. CR - 8. Sharifi M, Bay C, Skrocki L, Rahimi F, Mehdipour M. Moderate pulmonary embolism treated with thrombolysis (from the “MOPETT” Trial). Am J Cardiol. 2013;111(2):273-277. CR - 9. Wang C, Zhai Z, Yang Y, et al. Efficacy and safety of low dose recombinant tissue-type plasminogen activator for the treatment of acute pulmonary thromboembolism: a randomized, multicenter, controlled trial. Chest. 2010;137(2):254-262. CR - 10. Ichwan B, Darbha S, Shah MN, et al. Geriatric-specific triage criteria are more sensitive than standard adult criteria in identifying need for trauma center care in injured older adults. Ann Emerg Med. 2015;65(1):92-100. e3. CR - 11. Bayram B, Oray NÇ, Korkmaz E, Erdost HA, Gokmen N. Massive pulmonary embolism and cardiac arrest; thrombolytic therapy in a patient with recent intracranial surgery and glioblastoma multiforme. Am J Emerg Med. 2014;32(11):1441. e1-3. CR - 12. Girard P, Baldeyrou P, Le Guillou J-L, Lamer C, Grunenwald D. Thrombolysis for life-threatening pulmonary embolism 2 days after lung resection. Am Rev Respir Dis. 1993;147:1595-1595. UR - https://dergipark.org.tr/en/pub/omujecm/issue//879639 L1 - https://dergipark.org.tr/en/download/article-file/1575076 ER -