TY  - JOUR
T1  - Peripheral Silent Period In Cervical and Generalized Dystonia
AU  - Tutuncu, Melih
PY  - 2021
DA  - March
DO  - 10.5798/dicletip.888781
JF  - Dicle Medical Journal
JO  - diclemedj
PB  - Dicle University
WT  - DergiPark
SN  - 1300-2945
SP  - 205
EP  - 211
VL  - 48
IS  - 1
LA  - tr
AB  - Objective: Dystonia is a movement disorder described by continuous or alternating muscle contractions causing unusual postures or insistent motions. Abnormal sensorimotor integration and abnormalities in inhibitory pathways are thought to have a role in pathogenesis. This paper aims to research the state of inhibitory pathways in the spinal cord in dystonia through documenting a silent period (SP) through cutaneous stimulation (CuSP) or mixed nerve stimulation (MnSP).Methods: 23 patients with dystonia were included in the study. Also, 19 healthy subjects were included in the study as a control group. Ages were similar between two groups. (p=0.092). CuSP and MnSP are recorded through abductor pollicis brevis and median nerve at the wrist respectively. Results: Onset latency, time, and suppression index of CuSP were equivalent between two groups. Moreover, the initiation and terminate latencies of MnSP, also duration, were similar between these two groups. I2 suppression index was lower in generalized dystonia patients compared to patients with cervical dystonia (100.0 vs 86.7±21.4%; F=4.252, 0.035). Conclusions: The most striking result to emerge from the data is that there was lower suppression during CuSP in generalized dystonia patients. Our results suggest that spinal inhibitory circuits are less active if only there is clinical involvement of the relevant segment.
KW  - Dystonia
KW  - Cutaneous silent period
KW  - mixed nerve silent period
CR  - 1. Sanger TD. Chen D, Fehlings DL, Hallett M, et al. Definition and classification of hyperkinetic movements in childhood. Movement Disorders 2010; 25: 1538–49.
CR  - 2. Sitburana O, Chen Wu LJ, Sheffield JK, Davidson A, Jankovic J. Motor overflow and mirror dystonia Parkinsonism and Related Disorders 2009; 15: 758–61.
UR  - https://doi.org/10.5798/dicletip.888781
L1  - https://dergipark.org.tr/en/download/article-file/1609416
ER  -