@article{article_889541, title={Antibiotic Resistance Profile of Acinetobacter Species Isolated from Blood Cultures of Inpatients in Harran University Hospital}, journal={Harran Üniversitesi Tıp Fakültesi Dergisi}, volume={18}, pages={165–169}, year={2021}, DOI={10.35440/hutfd.889541}, author={Albayrak, Hatice and Bayraktar, Mehmet Tevfik and Yıldız Zeyrek, Fadile}, keywords={bacteremia, intensive care units, drug resistance, acinetobacter baumannii}, abstract={Objectives: Acinetobacter baumannii causes serious blood stream infections especially in immunocompromised and hospitalized patients. In this study, the distribution of antibacterial resistance among 92 A. baumannii isolates and 5 A. lwoffii isolates from blood cultures collected at Harran University Hospital (Urfa, Turkey) from 2017 to 2019 was investigated. Methods: Blood cultures were followed up in Versa-TREK (Trek Diagnostic System, USA) device; Passages were made to 5% blood agar and eosin methylene blue (EMB) agar. Passaged bacteria colonies were identified by MALDI-TOF MS (Bruker, Germany) and VITEK 2 compact system (bioMérieux, France). Sensitivities of Acinetobacter strains to meropenem, ciprofloxacin, amikacin, gentamicin, tobramycin, tigecycline and trimethoprim-sulfamethoxazole were tested by VITEK 2 compact system (bioMérieux, France). The results were evaluated by VITEK 2 device based on EUCAST’s guide.
Results: The antibiotic resistance rates of A. baumannii strains are as follows; ciprofloxacin 92%, imipenem %88, meropenem 88%, gentamicin 74%, tobramycin 67%, trimethoprim-sulfamethoxazole 63%, amikacin 53%, and tigecycline 10%. The resistance ratio of A. lwoffii strains are ciprofloxacin (40%), gentamicin 40%, amikacin 40%, tobramycin 40%, trimethoprim sulfamethoxazole 20%, imipenem %20, meropenem 20% and tigecycline 20%.
Conclusions: Our study suggests A. baumannii strains have high resistance ratios to available antibiotics. A. lwoffii also has an increasing resistance profile. Tigecycline is the most sensitive antibiotic, followed by amikacin and tobramycin. New antibiotics, rapid access to antibiotic sensitivity results and correct selection of empiric antibiotics has clinical importance.}, number={2}, publisher={Harran University}