@article{article_899430, title={Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model}, journal={Experimed}, volume={11}, pages={21–26}, year={2021}, DOI={10.26650/experimed.2021.899430}, author={Hakgüder Umay and Üstündağ Ünsal Veli and Tüzüner Burçin Alev and Genç, Nevin and İpekçi, Hazal and Özçelik, Reyhan and Tunalı-akbay, Tuğba and Şener, Göksel and Yarat, Ayşen and Emekli Alturfan, Ebru}, keywords={aging, brain, testis, oxidant, antioxidant}, abstract={The aim of our study was to examine the effects of exercise and cal-orie restriction on various tissue damage and antioxidant parame-ters in the brain and testis of rats in a natural aging model. For this purpose, male Sprague-Dawley rats were the control group (C), the elderly (A), the elderly with calorie restriction (ACR), the elderly who were exercised (AE) and the elderly who were exercised with calorie restriction (ACRE), they were divided into 5 groups. The con-trol group was composed of three-month-old animals. The other group consisted of 15-month-old rats. Exercise and calorie restric-tion were applied for 6 weeks. At the end of the experiment, lipid peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels and superoxide dismutase (SOD), catalase (CAT), glutathione-S-trans-ferase (GST) and tissue factor (TF) were determined in brain and testicular tissues homogenates. As a result of the study, the A group’s brain and testis LPO, NO levels and TF activity increased, GSH levels and SOD, CAT and GST activities decreased, when com-pared to the C group. As a result of our study, an increase in oxidant damage was observed with TF activity in the brain and testis in the natural aging model, and positive effects of exercise and calorie restriction on the antioxidant levels in the brain were determined, especially in aging.}, number={1}, publisher={Istanbul University}, organization={Marmara University Scientific Research and Project Commission}