TY - JOUR T1 - Iron(III) Complexes Derived From Azo-Containing Salicylaldoxime Ligands: Synthesis, Structures and Biological Evaluations TT - Azo Grubu Içeren Salisilaldoksim Ligandlarından Türetilen Demir (III) Kompleksleri: Sentez, Karakterizasyon Ve Biyolojik Değerlendirmeler AU - Serbest, Kerim AU - Dural, Bayram AU - Çol Ayvaz, Melek AU - Zengin, Ali AU - Emirik, Mustafa PY - 2021 DA - September Y2 - 2021 DO - 10.31202/ecjse.905307 JF - El-Cezeri JO - El-Cezeri Journal of Science and Engineering PB - Tayfun UYGUNOĞLU WT - DergiPark SN - 2148-3736 SP - 1184 EP - 1201 VL - 8 IS - 3 LA - en AB - Two novel mononuclear Fe(III) complexes derived from azo-containing salicylaldoxime ligands were synthesized and characterized by elemental analyses, spectroscopic data i.e. IR, 1H NMR, UV-Vis, electrospray ionization mass spectra, molar conductivity, and magnetic susceptibility measurements. Both the experimental and theoretical results strongly suggest that the ligands have a major contribution to the azo enol imine form instead of the hydrazo keto imine and azo keto amine forms in solution/solid-state. The electronic spectra of the ligands and their iron(III) complexes were calculated theoretically for the band assignments by using DFT and TD-DFT/CPCM methods. DNA binding, cleavage, and antioxidative activities of the investigated compounds were studied. It has been shown that the ligands and their iron (III) complexes tested bind to DNA via the intercalative mode. One of the most striking results among the antioxidant activity tests is that the hydroxyl radical scavenging activities of the ligands and complexes are higher than the standard antioxidant mannitol. KW - Azo-oxime KW - Iron(III) complex KW - DNA interaction KW - Antioxidant activity KW - DFT N2 - Azo grubu taşıyan salisilaldoksim türevi ligandlarından türetilen iki yeni mononükleer Fe (III) kompleksi sentezlendi ve elementel analizler, spektroskopik veriler, yani IR, 1H NMR, UV-Vis, elektrosprey iyonizasyon kütle spektrumları, molar iletkenlik ve manyetik duyarlılık ölçümleriyle karakterize edildi. Hem deneysel hem de teorik sonuçlar, çözelti / katı halde ligandların hidrazo keto imin ve azo keto amin formları yerine azo enol imin formunun daha büyük bir katkısı olduğunu güçlü bir şekilde göstermektedir. Ligandlar ve bunların demir(III) komplekslerinin elektronik spektrumları deneysel spektrumlardaki bant atamaları için, DFT ve TD-DFT / CPCM yöntemleri kullanılarak teorik olarak hesaplandı. Araştırılan bileşiklerin DNA bağlanması, bölünmesi ve antioksidatif aktiviteleri incelenmiştir. 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Biochem. 1971, 44, 276–287. doi: 10.1016/0003-2697(71)90370-8 UR - https://doi.org/10.31202/ecjse.905307 L1 - https://dergipark.org.tr/en/download/article-file/1670251 ER -