@article{article_926022, title={Glucosidase Inhibitory and Radical Scavenging Properties of Lichen Metabolites Salazinic Acid, Sekikaic Acid and Usnic Acid}, journal={Hacettepe Journal of Biology and Chemistry}, volume={40}, pages={7–21}, year={2012}, author={Verma, Neeraj and Behera, Bhaskar Charan and Sharma, Bharati Om}, keywords={Lichen metabolite,glucosidase inhibition,radical scavenging activity}, abstract={This paper reports α- and β-glucosidase inhibitory and radical scavenging potential of the metabolites; salazinic acid, sekikaic acid and usnic acid isolated from three terrestrial natural lichen species Ramalina celastri, Ramalina nervulosa and Ramalina pacifica of the genus Ramalinaceae. Lichen metabolites showed both glucosidase inhibitory and radical scavenging capacity. Half-inhibiting concentration IC50 values of the lichen metabolites; salazinic acid, sekikaic acid and usnic acid are 13.8 to 18.1, 13.8 to 14.6 and 17.7 to 18.9 μg/ mL for the α- and β-glucosidase inhibition. Scavenging of radicals are found with an IC50 values of salazinic acid, sekikaic acid and usnic acid are 17.2 to 20.5, 13.7 to 17.4 and 18.8 to 25.5 μg/mL respectively. Inhibition kinetic studies of the metabolite towards α- and β-glucosidase showed sekikaic acid and salazinic acid have competitive inhibition towards α-glucosidase activity and noncompetitive inhibition for β-glucosidase activity. Usnic acid showed noncompetitive type of inhibition for α-glucosidase and uncompetitive for β-glucosidase activity.}, number={1}, publisher={Hacettepe University}