@article{article_964153, title={The Effect Of Body Fat Ratio On Chemotherapy-Induced Nause-Vomiting}, journal={Eskisehir Medical Journal}, volume={3}, pages={198–204}, year={2022}, author={Sargın, Fatih and Beypınar, İsmail and Coşkun, Hasan Şenol}, keywords={Nausea, Vomiting, Chemotherapy, Body fat ratio, Body surface area, Body mass index}, abstract={Introduction: Chemotherapy still occupies an important place in cancer treatment, with the most common acute side effects of nausea and vomiting. Antineoplastic drug doses are adjusted according to the body surface area, calculated according to height and weight. The impact of the body-fat ratio on chemotherapy-induced nausea and vomiting was investigated in the study. Methods: Fifty-two patients who had received highly emetogenic chemotherapy without previous treatment were included in the study. Nausea and vomiting side effects were evaluated three weeks after the first chemotherapy under standard anti-emetic treatments before chemotherapy. Results: 75% of the patients were female, and the most common diagnosis was breast cancer. The most commonly used chemotherapy regimen was the combination of cyclophosphamide-doxorubicin-5-FU. The relationship between fat, fluid, and muscle tissue distributions was significantly correlated between SIRI and BCM methods. In 17 of 52 patients, nausea and vomiting developed due to chemotherapy. There was no significant effect of changes in body fat ratio (Siri method, p = 0.921), (BCM method, p = 0.783), body mass index (p=0.858), body surface area (p = 0.705), and body fluid compartment on nausea and vomiting after chemotherapy. Conclusion: Our study found no relationship between body composition and nausea and vomiting after chemotherapy. Therefore, especially in obese patients, it is recommended not to limit the dose by worrying about side effects and to give chemotherapy according to the actual results calculated.}, number={2}, publisher={Eskişehir Şehir Hastanesi}