@article{article_96980, title={The Effects of Potassium Bromate and Resveratrol on Fatty Acid Levels in Heart, Muscle and Brain of Wistar Rats}, journal={Gazi University Journal of Science}, volume={24}, pages={181–186}, year={2011}, author={Keser, Serhat and Yılmaz, Okkes and Tuzcu, Mehmet}, keywords={Resveratrol, KBrO3, Heart, Muscle, Brain}, abstract={<span style="font-family: "Times New Roman TUR"; mso-ansi-language: EN-US;" lang="EN-US"> <span style="font-size: small;"> <p class="MsoNormal" style="text-align: justify; margin: 0cm 46.2pt 0pt 36pt;"> <span style="font-size: 8pt; mso-ansi-language: EN-US;" lang="EN-US"> <span style="font-family: Times New Roman;">The aim of this study was to examine the effects of antioxidant resveratrol and carcinogen KBrO <sub>3 </sub> on the level of fatty acids in heart, muscle and brain of old female Wistar rats. In this study Wistar rats were randomly divided into three groups: 1. Control (C), 2. KBrO <sub>3 </sub> (P) (80 mg/kg, i.p. single dose) 3. Resveratrol+KBrO <sub>3 </sub> (Res) (80 mg/kg KBrO <sub>3 </sub> i.p. single dose, 33 mg/kg resveratrol, every other day, for 35 days). In heart, muscle and brain, fatty acid levels were measured by gas chromatography. </span> </span> </p> <p class="MsoNormal" style="text-align: justify; margin: 0cm 46.2pt 0pt 36pt;"> <span style="font-family: "Times New Roman TUR"; font-size: 8pt; mso-ansi-language: EN-US;" lang="EN-US">  </span> </p> <p class="MsoNormal" style="text-align: justify; margin: 0cm 46.2pt 0pt 36pt;"> <span style="font-family: "Times New Roman TUR"; font-size: 8pt; mso-ansi-language: EN-US;" lang="EN-US">In the present study, </span> <span style="font-size: 8pt; mso-ansi-language: EN-US;" lang="EN-US"> <span style="font-family: Times New Roman;">palmitoleic acid (16:1) and oleic acid (18:1) levels were significantly increased in the P and Res groups (p<0.05, p<0.001, respectively). Stearic acid (18:0) and docosahexaenoic acid (22:6) levels were significantly decreased in the P and Res groups (p<0.01, p<0.05, respectively) in the heart. Palmitoleic acid (16:1), oleic acid (18:1) and linolenic acid (18:3) levels were significantly increased in the P and Res groups (p<0.01, p<0.001, p<0.05, respectively). Docosahexaenoic acid (22:6) level was decreased in the P and Res groups (p<0.05) in the muscle. Palmitoleic acid (16:1) and stearic acid (18:0) levels were decreased in the Res group (p<0.05) in the brain. Our results confirm that resveratrol and KBrO <sub>3 </sub> treatment were affected the amount of important fatty acids which substrates in fatty acids metabolism of heart, muscle and brain of Wistar rats. </span> </span> </p> <span style="font-size: 8pt; mso-ansi-language: EN-US;" lang="EN-US"> <span style="font-family: Times New Roman;"> <p class="MsoNormal" style="margin: 0cm 46.2pt 0pt 36pt; text-align: justify;"> <strong style="mso-bidi-font-weight: normal;"> <span style="font-size: 8pt; mso-ansi-language: EN-US;" lang="EN-US">Key Words: </span> </strong> <span style="font-size: 8pt; mso-ansi-language: EN-US;" lang="EN-US"> Resveratrol, KBrO <sub>3 </sub>, Heart, Muscle, Brain. </span> <span style="font-size: 8pt;"> </span> </p> </span> </span> <p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 150%; mso-layout-grid-align: none; mso-outline-level: 1;">  </p> </span> </span> <span style="mso-ansi-language: EN-US;" lang="EN-US"> <span style="font-size: small;"> <span style="font-family: Times New Roman;">. </span> </span> </span>}, number={2}, publisher={Gazi University}