@article{article_97003, title={Chlorpyrifos Induced Cardiotoxicity in Rats and the Protective Role of Quercetin and Catechin}, journal={Gazi University Journal of Science}, volume={24}, pages={387–395}, year={2011}, author={Bas, Hatice and Kalender, Yusuf}, keywords={Chlorpyrifos, Flavonoids, Antioxidant Enzymes, Histopathology, Heart}, abstract={<span style="font-size:8pt;"> <span style="font-family:’Times New Roman’;"> </span> </span> <p class="MsoNormal" style="margin:0cm 37.2pt 0pt 45pt;">In this study, chlorpyrifos, catechin, quercetin and catechin- or quercetin+chlorpyrifos were given to Wistar rats for 4 weeks. Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT); decreased glutathione peroxidase (GPx) and glutathione–S-transferase (GST) activities in heart compared to the control. In catechin- and quercetin+chlorpyrifos groups, we observed the protective effects of flavonoids on examining parameters. Light microscopic investigations revealed that chlorpyrifos induced histopathological alterations in heart. Milder histopathological changes were observed co-treated with catechin- or quercetin+chlorpyrifos. As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren’t protect completely. </p>}, number={3}, publisher={Gazi University}