TY  - JOUR
T1  - EBER In Situ Hybridization Experience In Hodgkin Lymphoma
AU  - Gul, Gulen
AU  - Özcan, Mehmet Ali
AU  - Özkal, Sermin
PY  - 2021
DA  - September
DO  - 10.30621/jbachs.985629
JF  - Journal of Basic and Clinical Health Sciences
JO  - JBACHS
PB  - Dokuz Eylul University
WT  - DergiPark
SN  - 2564-7288
SP  - 201
EP  - 204
VL  - 5
IS  - 3
LA  - en
AB  - PurposeSeveral studies suggest that the relation of Epstein-Barr virus (EBV) and Hodgkin lymphoma (HL).  EBV and HL associations are reported at rates ranging from 20% to 100% that varies nationally and regionally.  In this study; in the case of Hodgkin's lymphoma, the presence of EBV encoded RNA (EBER) by in situ hybridization method and it’s distribution according to histopathological subtypes were investigated. MethodsWe investigated the presence of EBV in Hodgkin Lymphoma diagnosed 107 adult cases between 2013 and 2017, which chromogenic in situ hybridization with EBV RNA probe has been in routine use were evaluated retrospectively with pathology reports.ResultsThere were 69 males and 38. Nodular Sclerosis Classical Hodgkin Lymphoma (NSCHL) was the most common (63 cases, 58,9%) followed by Mixed Cellularity Classical Hodgkin Lymphoma (MCCHL) (23 cases,21,5%).  EBV was expressed in 40 cases (45,4%). High EBV association was found with NSCHL (50%) and MCCHL (48%). None of NLPHL was positive with EBER. ConclusionIn our series NSCHL is the most common histologic subtype and has higher percentages of EBV positivity as reported in developed countries. Our study has the largest series of patients investigating the relationship between HL and EBER in our country. For further comments more studies, particularly from Turkey, are needed to determine the actual epidemiological pattern of HL in the region and to define the role of EBV in HL.
KW  - EBER
KW  - EBV
KW  - Hodgkin Lymphoma
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UR  - https://doi.org/10.30621/jbachs.985629
L1  - https://dergipark.org.tr/en/download/article-file/1935932
ER  -