Aim: The aim of this study was to investigate and compare the autonomic and electrocardiographical examination in patients with chronic and inactive lepromatous leprosy with peripheric nerve conduction studies.

Material and Method: In our study, we included 37 lepromatous leprosy patients (mean age: 38±17 years;17 males and 20 females) and 59 normal subjects (mean age: 49±13; 24 males and 35 females) as control group. 12 leads ECG were recorded at a speed of 50 mm/s and nerve conduction parameters were studied in all the subject. QT and JT intervals were measured.

Results: Using Bazett formula, these inlevals were corrected for heart rate. Mean QT interval, JT interval. QTc interval, JTc interval, RR interval, QT dispersion (d), JT-d, QTc-d and JTc-d (344±37 ms, 283±34 ms. 12±0.61 ms, 10±0.82 ms, 760±140 ms, 80±33 ms, 66±29 ms, 3±1.4 ms and 2.5±1.3 ms; respectively) in lepromatous leprosy patients were significantly longer than that of the normal subjects (372±27 ms, 296±29 ms. 13±0.83 ms, 10±0.73 ms, 811 ± 125 ms, 30±11 ms. 28±12 ms, 1±0.37 ms and 0.97±0.36 ms; respectively) (p<0.05). No correlation was observed between the parameters of ventricular repolarization and the nerve conduction studying parameters.

Conclusion: The results of this study reveal thai dispersion of ventricular repolarization was increased in leprosy patients. We believed that longitudinal studies are necessary to determine the prognostic value of the repolarization dispersion parameters in the prediction of sudden autonomic complication in leprosy patients.