Amniotic membrane have been used in various surgical procedures and especially in the 1980s it was subjected to many researches about treatment of ocular surface disorders. Recently, it has been used for the treatment of persistent epithelial defects, thermal and alkali burns, bullous keratopathy, surgical treatment of pterygium, corneal surface reconstruction, conjunctival reconstruction, excimer laser PRK, prevention of corneal vascularization, treatment of scleral and corneal perforations, bleb revision and glaucoma filtering surgery. Further studies are required to determine the usage of amniotic membrane in different indications.