Aim:In this study, clinical effectiveness and tolerance to metronidazole treatment carried out in two different regimens were compared.

Materials and Methods: Forty-six cases applied to Infectious Disease Out Patient Clinics with dysentery complaints, were included in the study. In the stool samples, E. histolytica trophozoites were determined and no additional infectious agents that might cause diarrhea were present. In the group I. 10 day metronidazole treatment at 3x 750 mg/day dose was administered. In the group II., 5 day metronidazole treatment at 1x2000 mg/day dose were followed. During the study, daily clinical examination and parasitological test were performed for the first 5 day and on the day 14^th.

Results: In both groups, a complete treatment (%100) was obtained, and no difference in terms of effectiveness and side effects were noticed between treatment groups. Two cases from the group I did not complete the treatment regimen for unknown reasons. Compared with the 10 day regimen, treatment for 5 day is cost effective and more convenient. Additionally, no significant difference was noted between two groups.

Conclusion: It is deemed advisable that 5 day metronidazole treatment at 1x2000 mg/day dose might be used for treatment of intestinal amebiosis.