İmmünsüpresif İlaçlar ve HBV Reaktivasyonu

Year 2022, , 173 - 183, 29.04.2022

Betül Ersöz Acar

https://doi.org/10.47493/abantmedj.1051982

Abstract

Dünyada iki milyardan fazla insanın Hepatit B virüsü(HBV) ile enfekte olduğu tahmin edilmektedir. Hepatit B virüs reaktivasyonu(HBVr), immünsüpresif tedaviden sonra potansiyel olarak ölümcül olabilen bir komplikasyondur. İmmünsupresif tedavi görenlerde, HBV reaktivasyon riski, HBV enfeksiyonunun durumuna ve kullanılan ilacın immünsüpresif etkinlik derecesine göre değişmektedir. İmmünsüpresif tedaviye bağlı HBVr önlenebilir bir durum olduğundan, hangi hastaya nasıl ve ne zaman antiviral ilaç tedavisi verileceği önemlidir. Bu nedenle bu derlemede, HBVr ile ilgili risk gruplarının belirlenmesi ve antiviral tedavi yönetim stratejilerinin literatür eşliğinde gözden geçirilmesi amaçlanmıştır.

Keywords

Hepatit B virüsü, Reaktivasyon, Profilaksi

Immunsupressive Drugs and HBV Reactivation

Abstract

It is estimated that more than two billion people worldwide are infected with the Hepatitis B Virüs(HBV). Hepatitis B virüs reactivation(HBVr) is a potentially fatal complication after immunosuppressive therapy. The risk of HBV reactivation in those receiving immunosuppressive therapy varies according to the status of HBV infection and the degree of immunosuppressive effectiveness of the drug used. Since HBVr due to immunosuppressive therapy is a preventable condition, it is important how and when antiviral drug treatment will be given to which patient. Therefore, in this review, it is aimed to determine the risk groups related to HBVr and to review the antiviral treatment management strategies in the current literatüre.

Keywords

Hepatitis B Virus, Reactivation, Prophylaxis

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