Neutrophil-lymphocyte ratio in patients with ankylosing spondylitis

Year 2014, , 16 - 20, 01.01.2014

Mustafa Özşahin Hilmi Demirin Taner Uçgun Fatih Ermiş Özlem Admış Safinaz Ataoğlu

https://doi.org/10.5505/abantmedj.2014.16878

Abstract

OBJECTIVE: The purpose of the present study is to determine the association between neutrophil-lymphocyte ratio NLR and inflammation in ankylosing spondylitis AS . METHODS: Forty patients with ankylosing spondylitis and 30 healthy volunteers were included in the study. All data were obtained from patient registry database from in-patient and out-patient clinics. Detailed physical examination, and Bath Ankylosing Spondylitis Disease Activity Index BASDAI were recorded. Complete blood count CBC , CRP and ESR were performed recorded as laboratory tests in all participants. Lymphocyte and neutrophil counts were measured as part of the automated CBC.RESULTS: The CRP, which is an acute-phase reactant, and ESR were significantly higher in the patient group than those in the control group p0.05 .CONCLUSION: We observed that NLR levels weren’t significantly higher in AS patients compared to healthy individuals. NLR hasn’t seem a reasonable measure to detect systemic inflammation in AS patients. We believe that our preliminary results need to be complemented with further studies.

Keywords

Neutrophil-lymphocyte ratio, ankylosing spondylitis, inflammation, disease activity

Ankilozan spondilit hastalarında nötrofil-lenfosit oranı

Abstract

AMAÇ: Bu çalışmanın amacı, ankilozan spondilit AS hastalarındaki inflamasyon ile nötrofil-lenfosit oranı NLO arasındaki ilişkiyi belirlemektir.YÖNTEMLER: Ankilozan spondilit tanılı 40 hasta ve 30 sağlıklı gönüllü çalışmaya dahil edildi. Tüm veriler yatan ve poliklinik hasta kayıt veritabanından elde edildi. Tüm olguların Bath Ankilozan Spondilit Hastalık Aktivite İndeksi BASDAI , tam kan sayımı TKS , CRP ve ESH’ı da kapsıyan ayrıntılı fizik muayene ve laboratuvar bulguları kaydedildi. Lenfosit ve nötrofil sayısı otomatik TKS’nin bir parçası olarak ölçüldü.BULGULAR: Akut-faz reaktanı olan CRP ve ESH kontrol grubuna göre hasta grubunda anlamlı olarak daha yüksekti p 0.05 .SONUÇ: Bu çalışmada NLO düzeylerinin AS hastalarında sağlıklı bireylere göre anlamlı olarak yüksek olmadığı görüldü. Bu sonuç NLO’nun AS hastalarında sistemik inflamasyonu değerlendirmede uygun bir ölçü birimi olmadığını götermektedir. Bizim elde ettiğimiz bu ön sonuçların daha ileri çalışmalarla tamamlanması gerektiğine inanıyoruz.

Keywords

Nötrofil-lenfosit oranı, ankilozan spondilit, enflamasyon, hastalık aktivitesi

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