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Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up

Year 2016, Volume: 5 Issue: 1, 67 - 69, 01.01.2016
https://doi.org/10.5505/abantmedj.2016.24582

Abstract

Calcium channel blockers are drugs used in hypertension, arrhythmia and coronary heart diseases by blocking L type calcium channels. At high concentrations, calcium channels are blocked and calcium entry from L type channels is totally prevented.. In our study, we aimed to present the changes and the treatment approaches for the hospitalization period of a patient who applied to the emergency unit following the intake of high dose of calcium channel blocker, until the discharge.

References

  • Poggenborg RP, Videbaek L, Jacobsen IA. A case of amlodipine overdose. Basic Clin Pharmacol Toxicol 2006;99:209-12.
  • Hung YM, Olson KR. Acute amlodipine overdose intravenous calcium in a patient with severe renal insufficiency. Clin Toxicol (Phila) 2007; 45: 301-3. by high dose
  • DeWitt CR, Waksman JC. Pharmacology, pathophysiology and management of calcium channel blocker and beta-blocker toxicity. Toxicol Rev 2004; 23(4): 223-38
  • Faulker JK, McGibney D, Chasseaud LF, Perry pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily. Brit J Clin Pharmacol 22:21–25 IW (1986) The Lüscher TF, Cosentino F. The classification of calcium antagonists and their selection in the treatment of hypertension. ;55(4): 509-17 reappraisal. Drugs
  • Hung YM, Olson KR. Acute amlodipine overdose intravenous calcium in a patient with severe renal insufficiency. Clin Toxicol (Phila) 2007;45:301-3. by high dose
  • Baydın A, Yardan T, Dilek A, Nural MS, Eden AO, Gönüllü H. Yüksek dozda kalsiyum kanal blokeri alımına bağlı ölüm olgusu ve literatürün gözden geçirilmesi. Turk J Emerg Med 2008; 8-2: 84-9.
  • Kavalcı C, Durukan P, Ozbay Y. Kalsiyum Kanal Blokörü Zehirlenmesi: Olgu Sunumu. F.Ü. Sağ. Bil. Derg. 2007: (2): 85 – 86
  • Konca C, Yıldızdas RD, Sarı MY, Yükselmis U, Horoz OO, Yılmaz HL. Evaluation of poisoned children with calcium channel blockers or beta blockers drugs. Turk Arch Ped 2013; 138-44
  • Wood DM, Wright KD, Jones AL, Dargan PI. Metaraminol (Aramine) in the man- agement of a significant amlodipine overdose. Hum Exp Toxicol 2005; 24: 377
  • Heard K, Kline JA. Calcium Channel Blockers. Emergency medicine: a comprehensive study guide. New York: McGraw&Hill, : 1108-12. Tintinalli JE,(ed).
  • Enyeart JJ, Price WA, Hoffman DA, Woods L. Profound hyperglycemia and metabolic overdose. J Am Coll Cardiol 1983; 2(6): 31 after verapamil
  • Kline JA. Calcium Channel Blockers. In: Tintinalli JE, Kelen GD, Stapczynski JS. Emergency Medicine: A Comprehensive Study Guide. 5th Edition. New York: McGraw Hill; 2000: 1146-51.

Yoğun Takip Gerektiren Bir Zehirlenme Vakası; Amlodipin İntoksikasyonu

Year 2016, Volume: 5 Issue: 1, 67 - 69, 01.01.2016
https://doi.org/10.5505/abantmedj.2016.24582

Abstract

Kalsiyum kanal blokeri; hipertansiyon, aritmi ve koroner kalp hastalıklarında kullanılan, hücre zarında bulunan L tipi kalsiyum kanallarını bloke eden ilaçlardır. Yüksek konsantrasyonlarda kalsiyum kanalları bloke olur ve L tipi kanallardan kalsiyum girişi tamamen engellenir. Yazımızda yüksek doz kalsiyum kanal blokeri alım sonrasında acil servise başvuran hastanın taburculuğuna kadar olan dönemdeki klinik durumundaki değişimler ve tedavi yaklaşımlarının sunulması amaçlanmıştır.

References

  • Poggenborg RP, Videbaek L, Jacobsen IA. A case of amlodipine overdose. Basic Clin Pharmacol Toxicol 2006;99:209-12.
  • Hung YM, Olson KR. Acute amlodipine overdose intravenous calcium in a patient with severe renal insufficiency. Clin Toxicol (Phila) 2007; 45: 301-3. by high dose
  • DeWitt CR, Waksman JC. Pharmacology, pathophysiology and management of calcium channel blocker and beta-blocker toxicity. Toxicol Rev 2004; 23(4): 223-38
  • Faulker JK, McGibney D, Chasseaud LF, Perry pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily. Brit J Clin Pharmacol 22:21–25 IW (1986) The Lüscher TF, Cosentino F. The classification of calcium antagonists and their selection in the treatment of hypertension. ;55(4): 509-17 reappraisal. Drugs
  • Hung YM, Olson KR. Acute amlodipine overdose intravenous calcium in a patient with severe renal insufficiency. Clin Toxicol (Phila) 2007;45:301-3. by high dose
  • Baydın A, Yardan T, Dilek A, Nural MS, Eden AO, Gönüllü H. Yüksek dozda kalsiyum kanal blokeri alımına bağlı ölüm olgusu ve literatürün gözden geçirilmesi. Turk J Emerg Med 2008; 8-2: 84-9.
  • Kavalcı C, Durukan P, Ozbay Y. Kalsiyum Kanal Blokörü Zehirlenmesi: Olgu Sunumu. F.Ü. Sağ. Bil. Derg. 2007: (2): 85 – 86
  • Konca C, Yıldızdas RD, Sarı MY, Yükselmis U, Horoz OO, Yılmaz HL. Evaluation of poisoned children with calcium channel blockers or beta blockers drugs. Turk Arch Ped 2013; 138-44
  • Wood DM, Wright KD, Jones AL, Dargan PI. Metaraminol (Aramine) in the man- agement of a significant amlodipine overdose. Hum Exp Toxicol 2005; 24: 377
  • Heard K, Kline JA. Calcium Channel Blockers. Emergency medicine: a comprehensive study guide. New York: McGraw&Hill, : 1108-12. Tintinalli JE,(ed).
  • Enyeart JJ, Price WA, Hoffman DA, Woods L. Profound hyperglycemia and metabolic overdose. J Am Coll Cardiol 1983; 2(6): 31 after verapamil
  • Kline JA. Calcium Channel Blockers. In: Tintinalli JE, Kelen GD, Stapczynski JS. Emergency Medicine: A Comprehensive Study Guide. 5th Edition. New York: McGraw Hill; 2000: 1146-51.
There are 12 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Mansur Kürşad Erkuran This is me

Erhan Düzenli This is me

Tarık Ocak This is me

Arif Duran This is me

Hakan Bayır This is me

Publication Date January 1, 2016
Published in Issue Year 2016 Volume: 5 Issue: 1

Cite

APA Erkuran, M. K., Düzenli, E., Ocak, T., Duran, A., et al. (2016). Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up. Abant Medical Journal, 5(1), 67-69. https://doi.org/10.5505/abantmedj.2016.24582
AMA Erkuran MK, Düzenli E, Ocak T, Duran A, Bayır H. Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up. Abant Med J. January 2016;5(1):67-69. doi:10.5505/abantmedj.2016.24582
Chicago Erkuran, Mansur Kürşad, Erhan Düzenli, Tarık Ocak, Arif Duran, and Hakan Bayır. “Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up”. Abant Medical Journal 5, no. 1 (January 2016): 67-69. https://doi.org/10.5505/abantmedj.2016.24582.
EndNote Erkuran MK, Düzenli E, Ocak T, Duran A, Bayır H (January 1, 2016) Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up. Abant Medical Journal 5 1 67–69.
IEEE M. K. Erkuran, E. Düzenli, T. Ocak, A. Duran, and H. Bayır, “Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up”, Abant Med J, vol. 5, no. 1, pp. 67–69, 2016, doi: 10.5505/abantmedj.2016.24582.
ISNAD Erkuran, Mansur Kürşad et al. “Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up”. Abant Medical Journal 5/1 (January 2016), 67-69. https://doi.org/10.5505/abantmedj.2016.24582.
JAMA Erkuran MK, Düzenli E, Ocak T, Duran A, Bayır H. Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up. Abant Med J. 2016;5:67–69.
MLA Erkuran, Mansur Kürşad et al. “Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up”. Abant Medical Journal, vol. 5, no. 1, 2016, pp. 67-69, doi:10.5505/abantmedj.2016.24582.
Vancouver Erkuran MK, Düzenli E, Ocak T, Duran A, Bayır H. Amlodipine Intoxication: A Poisoning Case Requiring Intensive Follow-Up. Abant Med J. 2016;5(1):67-9.