Comparison of three different creatinine clearance calculation methods in patients with type 2 diabetes mellitus

Year 2018, Volume:3 Issue: 3, 152 - 155, 30.11.2018

Fatih Orkun Kundaktepe , Mustafa Genco Erdem , Şerife Ayşen Helvacı

https://doi.org/10.25000/acem.434689

Abstract

Aim: To determine
the most accurate and useful method for calculating creatinine clearance by
comparing the results of different methods.

Methods: One hundred type
2 diabetic patients who have been followed by Okmeydani Training and Research
Hospital Internal Medicine and/or diabetes outpatient clinics were included in
this study. Individuals with hypertension, acute kidney disease and renal
transplantation were excluded from the study.

Results: Glomerular
filtration rate (GFR) calculated with Cockcroft-Gault formula was significantly
affected by creatinine, weight, and age
(p<0.050 for all). GFR measured with Modification of Diet in Renal Disease (MDRD)
formula was significantly
affected by creatinine and age (p<0.050 for all) in a univariate model; in a
multivariate model, this was significantly
independently affected by creatinine (p=0.001). GFR measured with 24h urine was significantly affected by
creatinine, weight, and age (p<0.050 for
all) in a univariate model; in a multivariate model,
this was significantly
independently affected by weight (p=0.001).

Conclusion: In
this study, those three methods revealed similar results. All of three methods
can be used for evaluating renal functions in Type II diabetic patients but
creatinine clearance with 24 hours urine method requires two patient visits in
a row and a more complex biochemistry laboratory; so in our opinion, this
method may be used as an alternative to the other two methods.

Keywords

Creatinine clearance, glomerular filtration rate, type 2 diabetes

Tip 2 diyabetik bireylerde kreatinin klirensini hesaplamada kullanılan üç farklı yöntemin karşılaştırılması

Abstract

Amaç: Diyabetik
bireyler için kullanılabilecek en uygun kreatinin klirensi hesaplama metodunu
belirlemek amaçlandı.

Yöntem: Çalışmaya Okmeydanı
Eğitim Araştırma
Hastanesi iç
hastalıkları ve diyabet polikliniklerine başvurmuş 100 tane tip 2
diyabetik hasta dahil edildi. Hipertansiyon,
akut böbrek yetersizliği tanısı almış veya böbrek nakil alıcısı olan diyabetik
hastalar çalışma dışı bırakıldı.

Bulgular: Cockcroft-Gault
değerini kestirmede tek ve çok değişkenli modellerde yaş, ağırlık, kreatininin
anlamlı (hepsi için p<0,050) etkisi gözlenmiştir. MDRD değerini kestirmede
tek değişkenli modelde yaş, kreatininin; çok değişkenli modelde ise yalnızca kreatininin
anlamlı bağımsız (p=0,001) etkisi gözlenmiştir. 24 saatlik idrarda kreatinin
klirensi değerini kestirmede tek değişkenli modelde yaş, ağırlık, kreatinin
değerinin anlamlı (hepsi için p<0,050) etkisi gözlenmişken; çok değişkenli
modelde ise yalnızca ağırlık değerinin anlamlı bağımsız (p=0,001) etkisi
gözlenmiştir.

Sonuç: Bu çalışmada
üç yöntem de birbirleriyle uyumlu sonuç verdi. Tip II diyabetik hastalarda böbrek fonksiyonlarını
değerlendirmek için üç yöntemin tamamı kullanılabilir, ancak 24 saatlik idrar
yöntemiyle kreatinin klirensi, üst üste iki hasta ziyareti ve daha karmaşık bir
biyokimya laboratuvarı gerektirir; bizim görüşümüze göre, bu yöntem diğer iki
yönteme alternatif olarak kullanılabilir.

Keywords

Kreatinin klirensi, glomeruler filtrasyon hızı, tip 2 diyabet

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