Case Report
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İnce bağırsakta kitle oluşturarak ileus ile kendini gösteren AA amiloidoz

Year 2022, Volume 7, Issue 1, 21 - 23, 28.03.2022
https://doi.org/10.25000/acem.1050566

Abstract

Giriş: İntestinal amiloidoza sistemik amiloidozun bir parçası olarak sıklıkla rastlanır, ancak nadiren gastrointestinal kanalda sınırlı olabilir. Olgu sunumu: 54 yaşında erkek hasta gaz ve gaita çıkaramama şikayeti ile başvurdu. İleus nedeniyle acil olarak segmental barsak rezeksiyonu yapıldı. Makroskopik olarak bağırsak lümeninde en büyüğü 7x3x0.7 cm boyutlarında nodüler lezyonlar gözlendi. Mikroskobik olarak; submukozal alanda kitle oluşturan yoğun eozinofilik materyal birikimi kaydedildi. Bu materyal Crystal Violet, Congo Red ve Amiloid A ile pozitifti. Kappa ve Lambda negatifti. Monoklonal gamopati, serum amiloid A düzeylerinde artış, kronik inflamatuar hastalık, enfeksiyöz hastalık veya malignite saptanmadı. Olgu "intestinal AA amiloidoz" olarak değerlendirildi. Tartışma: Olgumuzda AA amiloidoz mevcut iken, kitle lezyonu oluşturmuş ve intestinal obstrüksiyona neden olmuştur. AA amiloidozun gastrointestinal kanalda sınırlı olması da olağandışıdır.

References

  • Reference1- Iida T, Yamano H, Nakase H. Systemic amyloidosis with gastrointestinal involvement: Diagnosis from endoscopic and histological views. J Gastroen Hepatol 2018;33(3):583-590.
  • Reference2- Petre S, Shah IA, Gilani N. gastrointestinal amyloidosis–clinical features, diagnosis and therapy. Aliment Pharm Ther 2008;27(11):1006-1016.
  • Reference3- Rowe K, Pankow J, Nehme F, Salyers W. Gastrointestinal amyloidosis: review of the literature. Cureus 2017;9(5).
  • Reference4- Gould M, Zarrin-Khameh N, Sellin J. Small bowel amyloidosis. Curr Gastroenterol Rep 2013;15(10):350.
  • Reference5- Hu H, Huang D, Ji M, Zhang S. Multiple myeloma with primary amyloidosis presenting with digestive symptoms: A case report and literature review. Arab J Gastroenterol 2020;21:54-58
  • Reference6- den Braber‐Ymker M, Heıjker S, Lammens M, Croockewıt S, Nagtegaal ID. Intestinal involvement in amyloidosis is a sequential process. Neurogastroent Motil 2018;30(12):e13469.
  • Reference7- Bansal R, Syed U, Walfish J, Aron J, Walfish A. Small bowel amyloidosis. Curr Gastroenterol Rep 2018;20(3):11.
  • Reference8- Schönland So, Hegenbart U, Bochtler T, Mangatter A, Hansberg M, Ho AD, et al. Immunohistochemistry in the classification of systemic forms of amyloidosis: a systematic investigation of 117 patients. Blood 2012;119(2):488-493.
  • Reference9- Tada S, Iida M, Yao T, Kawakubo K, Yao T, Okada M, et al. Endoscopic features in amyloidosis of the small intestine: clinical and morphologic differences between chemical types of amyloid protein. Gastrointest Endosc 1994;40:45‐50.
  • Reference10- Yamada M, Hatakeyama S, Tsukagoshı H. Gastrointestinal amyloid deposition in AL (primary or myeloma‐associated) and AA (secondary) amyloidosis: diagnostic value of gastric biopsy. Hum Pathol 1985;16:1206‐1211.
  • Reference11- Fonnescu C, Giovinale M, Verrecchia E, De Socıio G, Cerquaglia C, Curigliano V. et al. Gastrointestinal amyloidosis: a case of chronic diarrhea. Eur Rev Med Pharmacol Sci 2009;13 suppl 1:45–50

AA amyloidosis presented with ileus by forming a mass in the small intestine

Year 2022, Volume 7, Issue 1, 21 - 23, 28.03.2022
https://doi.org/10.25000/acem.1050566

Abstract

Introduction: Intestinal amyloidosis frequently encountered as a part of systemic amyloidosis, but rarely can be confined in the gastrointestinal tract. Case report: A 54-year-old male presented with the complaint of gas and stool discharge. Urgently segmental bowel resection was performed for ileus. Macroscopically nodular lesions, the largest at 7x3x0.7 cm in size were observed in the intestinal lumen. Microscopically; the accumulation of dense eosinophilic material that formed a mass in the submucosal area was noted. This material was positive with Crystal Violet, Congo Red and Amyloid A. Kappa and Lambda were negative. No monoclonal gammopathy, increase in serum amyloid A levels, chronic inflammatory disease, infectious disease or malignancy was determined. The case was evaluated as "intestinal AA amyloidosis". Discussion: While AA amyloidosis was existent in our case, it comprised a mass lesion and caused intestinal obstruction. It is also exraordinary for AA amyloidosis to be confined in gastrointestinal tract.

References

  • Reference1- Iida T, Yamano H, Nakase H. Systemic amyloidosis with gastrointestinal involvement: Diagnosis from endoscopic and histological views. J Gastroen Hepatol 2018;33(3):583-590.
  • Reference2- Petre S, Shah IA, Gilani N. gastrointestinal amyloidosis–clinical features, diagnosis and therapy. Aliment Pharm Ther 2008;27(11):1006-1016.
  • Reference3- Rowe K, Pankow J, Nehme F, Salyers W. Gastrointestinal amyloidosis: review of the literature. Cureus 2017;9(5).
  • Reference4- Gould M, Zarrin-Khameh N, Sellin J. Small bowel amyloidosis. Curr Gastroenterol Rep 2013;15(10):350.
  • Reference5- Hu H, Huang D, Ji M, Zhang S. Multiple myeloma with primary amyloidosis presenting with digestive symptoms: A case report and literature review. Arab J Gastroenterol 2020;21:54-58
  • Reference6- den Braber‐Ymker M, Heıjker S, Lammens M, Croockewıt S, Nagtegaal ID. Intestinal involvement in amyloidosis is a sequential process. Neurogastroent Motil 2018;30(12):e13469.
  • Reference7- Bansal R, Syed U, Walfish J, Aron J, Walfish A. Small bowel amyloidosis. Curr Gastroenterol Rep 2018;20(3):11.
  • Reference8- Schönland So, Hegenbart U, Bochtler T, Mangatter A, Hansberg M, Ho AD, et al. Immunohistochemistry in the classification of systemic forms of amyloidosis: a systematic investigation of 117 patients. Blood 2012;119(2):488-493.
  • Reference9- Tada S, Iida M, Yao T, Kawakubo K, Yao T, Okada M, et al. Endoscopic features in amyloidosis of the small intestine: clinical and morphologic differences between chemical types of amyloid protein. Gastrointest Endosc 1994;40:45‐50.
  • Reference10- Yamada M, Hatakeyama S, Tsukagoshı H. Gastrointestinal amyloid deposition in AL (primary or myeloma‐associated) and AA (secondary) amyloidosis: diagnostic value of gastric biopsy. Hum Pathol 1985;16:1206‐1211.
  • Reference11- Fonnescu C, Giovinale M, Verrecchia E, De Socıio G, Cerquaglia C, Curigliano V. et al. Gastrointestinal amyloidosis: a case of chronic diarrhea. Eur Rev Med Pharmacol Sci 2009;13 suppl 1:45–50

Details

Primary Language English
Subjects Medicine
Journal Section Case Report
Authors

Meryem İlkay EREN KARANİS> (Primary Author)
Konya City Hospital
0000-0002-1097-4592
Türkiye


Ramazan Saygin KERİMOGLU>
Konya City Hospital
0000-0003-3149-9636
Türkiye


İlknur KÜÇÜKOSMANOĞLU>
Konya City Hospital
0000-0002-5181-6152
Türkiye


Nermin KENİ BEGENDİ>
Konya City Hospital
0000-0002-7570-1552
Türkiye

Publication Date March 28, 2022
Published in Issue Year 2022, Volume 7, Issue 1

Cite

Bibtex @case report { acem1050566, journal = {Archives of Clinical and Experimental Medicine}, eissn = {2564-6567}, address = {hırkai şerif mah. keçeci çeşmesi sok. doktorlar sitesi b blok 6/7 Fatih İstanbul Türkiye}, publisher = {Mustafa HASBAHÇECİ}, year = {2022}, volume = {7}, number = {1}, pages = {21 - 23}, doi = {10.25000/acem.1050566}, title = {AA amyloidosis presented with ileus by forming a mass in the small intestine}, key = {cite}, author = {Eren Karanis, Meryem İlkay and Kerimoglu, Ramazan Saygin and Küçükosmanoğlu, İlknur and Keni Begendi, Nermin} }
APA Eren Karanis, M. İ. , Kerimoglu, R. S. , Küçükosmanoğlu, İ. & Keni Begendi, N. (2022). AA amyloidosis presented with ileus by forming a mass in the small intestine . Archives of Clinical and Experimental Medicine , 7 (1) , 21-23 . DOI: 10.25000/acem.1050566
MLA Eren Karanis, M. İ. , Kerimoglu, R. S. , Küçükosmanoğlu, İ. , Keni Begendi, N. "AA amyloidosis presented with ileus by forming a mass in the small intestine" . Archives of Clinical and Experimental Medicine 7 (2022 ): 21-23 <https://dergipark.org.tr/en/pub/acem/issue/69109/1050566>
Chicago Eren Karanis, M. İ. , Kerimoglu, R. S. , Küçükosmanoğlu, İ. , Keni Begendi, N. "AA amyloidosis presented with ileus by forming a mass in the small intestine". Archives of Clinical and Experimental Medicine 7 (2022 ): 21-23
RIS TY - JOUR T1 - AA amyloidosis presented with ileus by forming a mass in the small intestine AU - Meryem İlkayEren Karanis, Ramazan SayginKerimoglu, İlknurKüçükosmanoğlu, NerminKeni Begendi Y1 - 2022 PY - 2022 N1 - doi: 10.25000/acem.1050566 DO - 10.25000/acem.1050566 T2 - Archives of Clinical and Experimental Medicine JF - Journal JO - JOR SP - 21 EP - 23 VL - 7 IS - 1 SN - -2564-6567 M3 - doi: 10.25000/acem.1050566 UR - https://doi.org/10.25000/acem.1050566 Y2 - 2022 ER -
EndNote %0 Archives of Clinical and Experimental Medicine AA amyloidosis presented with ileus by forming a mass in the small intestine %A Meryem İlkay Eren Karanis , Ramazan Saygin Kerimoglu , İlknur Küçükosmanoğlu , Nermin Keni Begendi %T AA amyloidosis presented with ileus by forming a mass in the small intestine %D 2022 %J Archives of Clinical and Experimental Medicine %P -2564-6567 %V 7 %N 1 %R doi: 10.25000/acem.1050566 %U 10.25000/acem.1050566
ISNAD Eren Karanis, Meryem İlkay , Kerimoglu, Ramazan Saygin , Küçükosmanoğlu, İlknur , Keni Begendi, Nermin . "AA amyloidosis presented with ileus by forming a mass in the small intestine". Archives of Clinical and Experimental Medicine 7 / 1 (March 2022): 21-23 . https://doi.org/10.25000/acem.1050566
AMA Eren Karanis M. İ. , Kerimoglu R. S. , Küçükosmanoğlu İ. , Keni Begendi N. AA amyloidosis presented with ileus by forming a mass in the small intestine. Arch Clin Exp Med. 2022; 7(1): 21-23.
Vancouver Eren Karanis M. İ. , Kerimoglu R. S. , Küçükosmanoğlu İ. , Keni Begendi N. AA amyloidosis presented with ileus by forming a mass in the small intestine. Archives of Clinical and Experimental Medicine. 2022; 7(1): 21-23.
IEEE M. İ. Eren Karanis , R. S. Kerimoglu , İ. Küçükosmanoğlu and N. Keni Begendi , "AA amyloidosis presented with ileus by forming a mass in the small intestine", Archives of Clinical and Experimental Medicine, vol. 7, no. 1, pp. 21-23, Mar. 2022, doi:10.25000/acem.1050566

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