The relationship between good collateral development and magnesium/phosphate ratio in chronic total occlusion

Year 2022, Volume: 5 Issue: 3, 126 - 130, 15.10.2022

Mehmet Kış , Oktay Şenöz , Tuncay Güzel

https://doi.org/10.53446/actamednicomedia.1147651

Cited By: 1

Abstract

Objective: Coronary collateral formation can be triggered by many acquired factors such as ischemia and growth factors, which ultimately manifests as differences in the quality of the coronary collateral circulation (CCC) in patients. Low magnesium (Mg) levels can increase endothelial cell dysfunction and potentially increase the risk of thrombosis and atherosclerosis. However, it has been reported that high serum phosphate (P) levels are correlated with the development of atherosclerosis and mortality. In this article, we aimed to reveal the relationship between CCC quality and Mg/P ratio in chronic total occlusion (CTO).
Methods: A total of 269 patients with detected CTO in coronary angiography between March 2014 and June 2018 were included in the study. The patients were divided into two groups as group I (127 patients) and group II (142 patients) according to the Rentrop classification. The study is a retrospective, observational study.
Results: In the multivariable regression analysis; smoking (p=0.004), triglyceride (p<0.001) and Mg/P ratio (p<0.001) parameters were independent predictors affecting CCC in CTO. Mg/P value was statistically lower in the group I (0.49±0.17) than group II (0.62±0.12) (p <0.001). The ideal Mg/P cut-off value was 0.56 that calculated by the Youden index had 69% sensitivity, and 64% specificity for collateral development of CTO.
Conclusion: Mg/P is a parameter that affects coronary collateral development. High Mg/P ratio level is associated with good collateral development in patients who had CTO.

Keywords

Coronary artery disease, Chronic total occlusion, Mg/P ratio, collateral development

Supporting Institution

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Thanks

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Kronik total oklüzyonda iyi kollateral gelişimi ile magnezyum/fosfat oranı arasındaki ilişki

Abstract

Amaç: Koroner kollateral oluşumu, iskemi ve büyüme faktörleri gibi birçok edinsel faktör tarafından tetiklenebilir bu da hastalarda koroner kollateral dolaşımın (KKD) kalitesinde farklılıklar olarak ortaya çıkar. Düşük magnezyum (Mg) seviyeleri endotel hücrelerinin fonksiyon bozukluğunu artırabilir ve potansiyel olarak tromboz ve ateroskleroz riskini artırabilir. Bununla birlikte yüksek serum fosfat (P) seviyelerinin ateroskleroz gelişimi ve mortalite ile ilişkili olduğu bildirilmiştir. Bu çalışmada kronik total oklüzyonda (KTO) KKD kalitesi ile Mg/P oranı arasındaki ilişkiyi araştırmayı amaçladık.
Yöntem: Temmuz 2014 ile Şubat 2018 tarihleri arasında koroner anjiyografide KTO saptanan toplam 269 hasta çalışmaya dahil edildi. Hastalar Rentrop sınıflamasına göre grup I (127 hasta) ve grup II (142 hasta) olarak iki gruba ayrıldı. Çalışma retrospektif, gözlemsel bir çalışmadır.
Bulgular: Çok değişkenli regresyon analizinde; sigara (p=0,004), trigliserid (p<0,001) ve Mg/P oranı (p<0,001) KTO'da KKD'ı etkileyen bağımsız prediktörlerdir. Mg/P değeri grup I'de (0,49±0,17) grup II'ye (0,62±0,12) göre istatistiksel olarak daha düşüktü (p<0,001). Youden indeksi ile hesaplanan ideal Mg/P cut-off değeri 0,56 olup, KTO'da iyi kollateral gelişimi için %69 duyarlılık ve %64 özgüllüğe sahiptir.
Sonuç: Mg/P oranı, koroner kollateral gelişimi etkileyen bir parametredir. Yüksek Mg/P oranı, KTO'su olan hastalarda iyi kollateral gelişim ile ilişkilidir.

Keywords

Koroner arter hastalığı, Kronik total oklüzyon, Mg/P oranı, kollateral gelişim

Project Number

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