HER2 Assessment in Gastric Carcinoma

Year 2014, , 42 - 51, 01.12.2014

Sultan Çiğdem Irkkan

https://doi.org/10.5505/aot.2014.24633

Abstract

Addition of Trastuzumab in management of advanced gastric and gastroesophageal carcinomas, has provided benefit in overall survival of those with Her2 positive tumors. For eligibility of patients for this therapy, Her2 test is done. Following breast carcinomas, Her2 testing in gastric carcinomas are also added to the routine work of pathology laboratories. Although Her2 test in gastric carcinomas has similar features with that of breast, it has some aspects to be known well. These aspects have arisen mainly because heterogenous Her2 positivity and basolateral settling of the receptors in gastric carcinoma cells. Although Her2 immunohistochemical and in situ hybridisation tests are among routine tests of most laboratories, scoring criteria are complex and need experience for accuracte results. In achieving accurate results in these tests, prenanalytical as well as the analytical conditions, are also effective.

Keywords

Gastric neoplasms, HER2

Mide Kanserlerinde HER2 Değerlendirmesi

Abstract

İlerlemiş mide ve gastroözofageal bileşke karsinomlarında tedaviye Trastuzumab eklenmesi, Her2 pozitif tümörlü hastalarda sağkalım avantajı sağlamıştır. Bu tedaviden faydalanabilecek hastaların Her2 testi ile belirlenmesi gerekmektedir. Meme karsinomlarından sonra, mide karsinomlarında da Her2 testi patoloji laboratuarlarının günlük işleri arasına girmiştir. Mide karsinomlarında Her2 testi, meme karsinomlarındakine benzer özellikler içermekle birlikte, bilinmesi gereken farklı yönleri de vardır. Bu farklar, başlıca mide karsinomlarında Her2 pozitifliğinin daha heterojen olması ve karsinom hücre membranlarında, reseptörlerin bazolateral yerleşimlerinden kaynaklanmaktadır. Her2 testinde kullanılan immünhistokimyasal ve in situ hibridizasyon testleri, çoğu laboratuarda kullanılır testler arasında olmakla birlikte, skorlama kriterleri karışıktır ve doğru sonuç için deneyim gerektirmektedir. Bu testlerde doğruluğu sağlamak için analitik koşullar kadar preanalitik koşullar da etkilidir.

Keywords

Mide neoplazmları, HER2

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