Dentinogenic Ghost‑Cell Tumor: An Uncommon Entity

Year 2024, Volume: 10 Issue: 2, 211 - 216, 16.08.2024

Görkem Tekin , Nesrin Saruhan , Ömür Dereci , Yasin Koşar , Melek Gürbüz , Fuat Açıkalın

Abstract

Introduction: Dentinogenic Ghost Cell Tumor (DGCT) constitutes less than 3% of all odontogenic tumors, making it a rare entity characterized by local invasion. The histopathological features of DGCT are the presence of ghost cell layers and formation of dentinoid material with an ameloblastoma-like odontogenic epithelial proliferation. The peripheral variant of DGCT behaves less aggressively than the intraosseous variant and usually occurs on the anterior region of both jaws.
Case Report: A 60-year-old male patient was referred to the oral and maxillofacial surgery clinic with a complaint of a painless swelling extending from the left upper molar region to the canine region. In the radiographic examination, destruction was observed in the maxillary bone where the lesion was located. Incisional biopsy revealed the diagnosis of DGCT. The patient was scheduled for surgery, but the lesion could not be excised because he refused the treatment.
Conclusion: DGCT may present as a malignant-like lesion in the maxillary posterior region. Therefore, histopathological differential diagnosis must be made.

Keywords

Ghost Cell, Maxilla, Oral Cavity, Tumor

Dentinojenik Hayalet Hücre Tümör: Yaygın Olmayan Entite

Abstract

Amaç: Dentinojenik hayalet hücreli tümör (DHHT), tüm odontojenik tümörlerin %3'ünden azını oluşturur ve bu da onu lokal invazyonla karakterize nadir bir antite haline getirmektedir. DHHT'nin histopatolojik özellikleri, hayalet hücre tabakalarının varlığı ve dentinoid materyalin oluşumu ile ameloblastoma benzeri odontojenik epitelyal proliferasyonudur. DHHT'nin periferik varyantı, intraosseöz varyantına göre daha az agresif davranır ve genellikle her iki çenenin ön bölgesinde görülmektedir.
Olgu Sunumu: 60 yaşındaki erkek hasta, sol üst çene molar bölgesinden kanin bölgesine kadar uzanan ağrısız şişlik şikayeti ile ağız, diş ve cerrahisi kliniğine yönlendirildi. Radyografik incelemede, lezyonun bulunduğu üst çene kemiğinde rezorpsiyon gözlendi. İnsizyonel biyopsi sonucunda DHHT tanısı konuldu. Hasta ameliyat için planlandı ancak tedaviyi reddettiği için lezyon çıkarılamadı.
Sonuç: DHHT, maksiller posterior bölgede malign benzeri bir lezyon olarak ortaya çıkabilir. Bu nedenle mutlaka histopatolojik ayırıcı tanı yapılmalıdır.

Keywords

Hayalet Hücre, Maksilla, Oral kavite, Tümör

References

• Kamat SS, Diwakar GS, Ahmed MB, Shetty PR. Peripheral dentinogenic ghost cell tumor. Med J DY Patil Univ. 2013;6(4):436-9
• de Arruda JAA, Monteiro JLGC, Abreu LG, et al. Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review. J Oral Pathol Med. 2018;47(8):721-30.
• Praetorius F, Hjørting-Hansen E, Gorlin RJ, Vickers RA. Calcifying odontogenic cyst. Range, variations and neoplastic potential. Acta Odontol Scand. 1981;39(4):227- 40.
• Præ´torius F, Ledesma-Montes C. Dentinogenic ghost cell tumour. In: L Barnes, JW Eveson, P Reichart, D Sidransky, eds. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press, 2005; 314.
• El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ. The fourth edition of the head and neck World Health Organization blue book: editors’ perspectives. Hum Pathol. 2017;66:10-12.
• Vered M, Wright JM. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours. Head Neck Pathol. 2022;16(1):63-75.
• Pinheiro TN, de Souza APF, Bacchi CE, Consolaro A. Dentinogenic ghost cell tumor: A bibliometric review of literature. J Oral Dis Markers 2019;3(1):9-17.
• Patankar SR, Khetan P, Choudhari SK, Suryavanshi H. Dentinogenic ghost cell tumor: A case report. World J Clin Oncol. 2019;10(4):192-200.
• Bafna SS, Joy T, Tupkari JV, Landge JS. Dentinogenic ghost cell tumor. J Oral Maxillofac Pathol. 2016;20(1):163.
• Sheikh J, Cohen MD, Ramer N, Payami A. Ghost Cell Tumors. J Oral Maxillofac Surg. 2017;75(4):750-8.
• Barnes L, Eveson JW, Reichert P, Sidransky D, eds. World Health Organization Classification of Tumors. Pathology and Genetics of Head and Neck Tumors. Lyon, France: IARC Press; 2005.
• Novembre D, Giofrè E, Barca I, Ferragina F, Cristofaro MG. A rare case of mandibular dentinogenic ghost cell tumor: Histopathological, clinical and surgical management. J Oral Maxillofac Pathol. 2021;25(1):206.
• de Souza Vieira G, de Pinho Montovani P, Rozzade- Menezes RE, Cunha KSG, Conde DC. Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review. Head Neck Pathol. 2021;15(4):1265-83.
• Ledesma-Montes C, Gorlin RJ, Shear M, et al. International collaborative study on ghost cell odontogenic tumours: calcifying cystic odontogenic tumour, dentinogenic ghost cell tumour and ghost cell odontogenic carcinoma. J Oral Pathol Med. 2008;37(5):302-8.
• Gupta S, Singh S, Anjum R, Sharma R. Dentinogenic ghost-cell tumor of the maxilla: A case report and review of literature. J Oral Maxillofac Pathol. 2019;23(3):478.
• Agrawal Y, Naidu GS, Makkad RS, et al. Dentinogenic ghost cell tumor-a rare case report with review of literature. Quant Imaging Med Surg. 2017;7(5):598-604.
• Bavle RM, Muniswamappa S, Makarla S, Venugopal R. Variations in Aggressive and Indolent Behaviour of Central Dentinogenic Ghost Cell Tumor. Case Rep Dent. 2020;2020:8837507.
• Reddy V, Wadhwan V, Singh R, Bansal V. Dentinogenic ghost cell tumor: Case report of a rare central variant and literature review. J Oral Maxillofac Pathol. 2022;26(1):68- 72.