Autogenous Dentin Grafts and Their Applications

Yıl 2023, , 321 - 327, 13.05.2023

Ahmet Berkant Özen , İnci Rana Karaca

https://doi.org/10.54617/adoklinikbilimler.1224638

Öz

Autogenous grafts are accepted as the gold standard for grafting bone defects in various sources. The clinical use of dentin grafts, which can be an example of autogenous grafts, provides the use of teeth seen as medical waste and offers an alternative grafting opportunity to traditional methods. Its organic and inorganic structure is similar to bone, which makes it possible to use it as a graft material. In this review, information is presented about the use of autogenous dentin grafts in clinical studies and animal experiments, in bone defect areas, sinus grafting, implant surfaces, augmentation procedures with various grafting techniques.These studies with high success rates increase the popularity of autogenous dentin grafts.

Anahtar Kelimeler

Demineralization of dentin, Bone grafts, Bone regeneration

Otojen Dentin Greftleri ve Uygulamaları

Öz

Çeşitli kaynaklarda kemik defektlerinin greftlenmesinde otojen greftler altın standart olarak kabul edilmektedir. Otojen greftlere örnek olabilecek dentin greftlerinin klinik kullanımı, tıbbi atık olarak görülen dişlerin kullanımını sağlayıp geleneksel yöntemlere alternatif greftleme imkanı sunmaktadır. Organik ve inorganik yapısı kemiğe benzerlik göstermektedir, bu durum greft materyali olarak kullanımı göz önüne getirmektedir. Bu derlemede, otojen dentin greftlerinin klinik çalışmalarda ve hayvan deneylerinde, kemik defektli bölgelerde, sinüs greftlemelerinde, implant yüzeylerinde, ogmentasyon işlemlerinde çeşitli greftleme teknikleriyle kullanım alanlarına ilişkin yapılan örnek çalışmalar hakkında bilgi sunulmaktadır. Başarı oranları yüksek olan bu çalışmalar otojen dentin greftlerinin popülerliğini artırmaktadır.

Anahtar Kelimeler

Dentin demineralizasyonu, Kemik greftleri, Kemik rejenerasyonu

Kaynakça

• García-Gareta E, Coathup MJ, Blunn GW. Osteoinduction of bone grafting materials for bone repair and regeneration. Bone 2015;81:112-21.
• Sukumar S, Drizhal I. Bone grafts in periodontal therapy. Acta Medica 2008;51:203-7.
• Roberts TT ,Rosenbaum AJ. Bone grafts, bone substitutes and orthobiologics. Organogenesis 2012;8:114–24.
• Khan SN, Cammisa FP, Jr., Sandhu HS, Diwan AD, Girardi FP, Lane JM. Kemik aşılamanın biyolojisi. J Am Acad Orthop Surg 2005;13:77-86
• Çetiner EY. Diş çekim soketlerine uygulanan otojen dentin greftinin kemik iyileşmesi üzerine etkilerinin incelenmesi [tez].Samsun: Ondokuz Mayıs Üniversitesi Diş Hekimliği Fakültesi; 2018.
• Murata M, Akazawa T, Mitsugi M, Um IW, Kim, KW, Kim YK. Human Dentin as Novel Biomaterial for Bone Regeneration. In: Rosario Pignatello R. (ed.) Biomaterials- Physics and Chemistry, InTech. 2011; 127-140.
• Işık G, Koyuncu BÖ, Becerik SÇ, Günbay T. Otojen diş kemik greftinin biyolojik özellikleri ve klinik kullanımı. Atatürk Üniv Diş Hek Fak Derg 2020;30:659-70.
• Cao CY, Mei ML, Li QL, Lo EC, Chu CH. Methods for biomimetic remineralization of human dentine: a systematic review. Int J Mol Sci 2015;16:4615-27.
• Silver FH, Langley KH, Trelstad RL. Type I collagen fibrillogenesis: initiation via reversible linear and lateral growth steps. Biopolymers 2004;18:2523-35.
• Boskey AL. Biomineralization: conflicts, challenges, and opportunities. J Cell Biochem Suppl 1998;30-31:83-91.
• Minamizato T, Koga T, Takashi I, Nakatani Y, Umebayashi M, Sumita Y, et al. Clinical application of autogenous partially demineralized dentin matrix prepared immediately after extraction for alveolar bone regeneration in implant dentistry: a pilot study. Int J Oral Maxillofac Surg 2018;47:125-32.
• Van der Rest M, Garrone R. Collagen family of proteins. FASEB J 1991;5:2814-23.
• Iohara K, Nakashima M, Ito M, Ishikawa M, Nakasima A, Akamine A. Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2. J Dent Res 2004;83:590-5.
• Ike M, Urist MR. Recycled dentin root matrix for a carrier of recombinant human bone morphogenetic protein. J Oral Implantol 1998;24:124-32.
• Um IW, Ku JK, Lee BK, Yun PY, Lee JK, Nam JH. Postulated release profile of recombinant human bone morphogenetic protein-2 (rhBMP-2) from demineralized dentin matrix. J Korean Assoc Oral Maxillofac Surg 2019;45:123-8.
• Linde A. Dentin matrix proteins: composition and possible functions in calcification. Anat Rec 1989;224:154-66.
• Reis-Filho CR, Silva ER, Martins AB, Pessoa FF, Gomes PV, de Araujo MS, et al. Demineralised human dentine matrix stimulates the expression of VEGF and accelerates the bone repair in tooth sockets of rats. Arch Oral Biol 2012;57:469-76.
• Koga T, Minamizato T, Kawai Y, Miura K, IT, Nakatani Y, et al. Bone regeneration using dentin matrix depends on the degree of demineralization and particle size. PloS One 2016;11:e0147235.
• Huggins C, Wiseman S, Reddi AH. Transformation of fibroblasts by allogeneic and xenogeneic transplants of demineralized tooth and bone. J Exp Med 1970;132:1250-8.
• Finkelman RD, Mohan S, Jennings JC, Taylor AK, Jepsen S, Baylink DJ. Quantitation of growth factors IGF-I, SGF/IGF-II, and TGF-beta in human dentin. J Bone Miner Res 1990;5:717-23.
• Kim YK, Kim SG, Byeon JH, Lee HJ, Um IU, Lim SC, et al. Development of a novel bone grafting material using autogenous teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:496-503.
• Kim YK, Kim SG, Bae JH, Um IW, Oh JS, Jeong KI. Guided bone regeneration using autogenous tooth bone graft in implant therapy: case series. Implant Dent 2014; 23:138-43.
• Lee JY, Kim YK. Retrospective cohort study of autogenous tooth bone graft. Oral Biol Res 2012;36:39-43.
• Upadhyay P, Blaggana V, Tripathi P, Jindal M. Treatment of furcation involvement using autogenous tooth graft with 1-year follow-up: a case series. Clin Adv Periodontics 2019;9:4-8.
• Joshi CP, Dani NH, Khedkar SU. Alveolar ridge preservation using autogenous tooth graft versus beta-tricalcium phosphate alloplast: A randomized, controlled, prospective, clinical pilot study. J Indian Soc Periodontol 2016;20:429-34.
• Jeong KI, Kim SG, Kim YK, Oh JS, Jeong MA, Park JJ. Clinical study of graft materials using autogenous teeth in maxillary sinus augmentation. Implant Dent 2011;20:471–5.
• Jun SH, Ahn JS, Lee JI, Ahn KJ, Yun PY, Kim YK. A prospective study on the effectiveness of newly developed autogenous tooth bone graft material for sinus bone graft procedure. J Adv Prosthodont 2014;6:528-38.
• Reddi AH, Huggins CB. Influence of geometry of transplanted tooth and bone on transformation of fibroblasts. Proc Soc Exp Biol Med 1973;143:634-7.
• Kim YK, Kim SG, Um IW, Kim KW. Bone grafts using autogenous tooth blocks: A case series. Implant Dent 2013;22:584-9.
• Murata M, Akazawa T, Takahata M, Ito M, Tazaki J, Hino J, et al. Bone induction of human tooth and bone crushed by newly developed automatic mill. J Ceram Soc Jpn 2010;118:434–7.
• Um IW, Kim YK, Mitsugi M. Demineralized dentin matrix scaffolds for alveolar bone engineering. J Indian Prosthodont Soc. 2017;17:120-7.
• Inoue T, Deporter DA, Melcher AH. Induction of cartilage and bone by dentin demineralized in citric acid. J Periodontal Res 1986;21:243–55.
• Binderman I, Hallel G, Nardy C, Yaffe A, Sapoznikov L. A novel procedure to process extracted teeth for immediate grafting of autogenous dentin. J Interdiscipl Med Dent Sci 2014;2:2.
• Andersson L, Bodin I, Sörensen S. Progression of root resorption following replantation of human teeth after extended extraoral storage. Endod Dent Traumatol 1989;5:38-47.
• Malmgren B. Ridge preservation/decoronation. J Endod 2013;39:S67-72.
• Ku JK, Lee JK, Min CG, Kim YM, Um IW. Moldable autogenous tooth bone graft (M-AutoBT) in sinus-related defects with implant: 3 case reports of long-term follow up. Journal of Dental Implant Research 2009;38:24-9.
• Kim YK, Lee JK, Kim KW, Um IW, Murata M. Healing mechanism and clinical application of autogenous tooth bone graft material. In: Pignatello R (ed) Advances in Biomaterials Science and Biomedical Applications, InTech, Rijeka, Croatia: 2013;405-435.
• Kim YK, Lee JH, Um IW, Cho WJ. Guided Bone Regeneration Using Demineralized Dentin Matrix:Long-Term Follow-Up. J Oral Maxillofac Surg 2016;74:515.e1-9.
• Kim SK, Kim SW, Kim KW. Effect on bone formation of the autogenous tooth graft in the treatment of peri-implant vertical bone defects in the minipigs. Maxillofac Plast Reconstr Surg 2015;37:2.
• Elfana A, El-Kholy S, El-Sayed KF. Alveolar ridge preservation using autogenous whole-tooth versus demineralized dentin grafts: A randomized controlled clinical trial. Clinical Oral Implants Res 2021;32:539-48.
• Del Canto-Díaz A, De Elío-Oliveros J, Del CantoDíaz M, Alobera-Gracia MA, Del Canto-Pingarrón M, Martínez-González JM. Use of autologous toothderived graft material in the post-extraction dental socket. Pilot study. Med Oral Patol Oral Cir Bucal 2019;24:53-60.
• Lee DH, Yang KY, Lee JK. Porcine study on the efficacy of autogenous tooth bone in the maxillary sinus. J Korean Assoc Oral Maxillofac Surg 2013;39:120-6.
• Korsch M. Tooth shell technique: A proof of concept with the use of autogenous dentin block grafts. Aust Dent J 2021;66:159-68.
• Pang KM, Um IW, Kim YK, Woo JM, Kim SM, Lee JH. Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: a prospective randomized clinical trial in comparison with anorganic bovine bone. Clin Oral Implant Res 2017;28:809-15.
• Mercan U, Çakır M, Meral DG. Osteoporoti̇k sıçanlarda hyaluroni̇k asi̇ti̇n denti̇n grefti̇yle korti̇kal kemi̇k defektleri̇nde kemi̇k i̇yi̇leşmesi̇ne etki̇si̇ni̇n değerlendi̇ri̇lmesi. EÜ Dişhek Fak Derg 2020;4:121-29.