A New Dimension in Periodontal Regenerative Therapy: 3D Cell Culture

Yıl 2023, Cilt: 12 Sayı: 1, 183 - 189, 18.01.2023

Kadriye Altıkat , Ayşe Emel Ökte

https://doi.org/10.54617/adoklinikbilimler.1118229

Öz

Therapies established with three-dimensional (3D) culture environments, particularly developed by using Mesenchymal Stem Cells (MSCs), have come to the fore in recent years. Functions of tissues and organs with cell cultures, their behavior in the case of an illness, and their interactions with drugs can be evaluated in vitro. This review examined the methods of creating 3D culture environments, their advantages and disadvantages, as well as their use in periodontal regenerative therapy.

Anahtar Kelimeler

Cell Culture Techniques, Guided Tissue Regeneration, Periodontal Diseases, Periodontology

Periodontal Rejeneratif Tedavide Yeni Bir Boyut: Üç Boyutlu Hücre Kültürü

Öz

Periodontal rejeneratif tedavide özellikle Mezenkimal Kök Hücrelerden (MKH) yararlanılarak geliştirilen üç boyutlu (3D) kültür ortamları ile oluşturulan tedaviler son yıllarda ön plana çıkmaktadır. Hücre kültürleri ile doku ve organların fonksiyonları, hastalık durumunda göstermiş oldukları davranışları ve ilaçlarla olan etkileşimleri in vitro olarak değerlendirilebilmektedir. Bu derlemede 3D kültür ortamların oluşturulma metotları, avantaj ve dezavantajlarının yanı sıra periodontal rejeneratif tedavide kullanım alanları incelenmiştir.

Anahtar Kelimeler

Hücre kültürü teknikleri, Periodontal hastalıklar, Periodontoloji, Yönlendirilmiş doku rejenerasyonu

Kaynakça

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