Research Article
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Year 2020, Volume: 10 Issue: 1, 133 - 145, 25.06.2020
https://doi.org/10.37094/adyujsci.714081

Abstract

References

  • [1] Ahmed, D., Khan, M.M., Saeed, R., Comperative analysis of phenolics, flavonoids and antioxidant and antibacterial potential of methanolic, hexanic and aqueous extracts from Adiantum caudatum leave, Antioxidants. 4, 394-409, 2015.
  • [2] Valko, M., Leibfritz, D., Moncol, J., Cronn, M.T.D., Mazur, M., Telser, J., Free redicals and antioxidants in normal physiological functions and human disease, International Journal of Biochemistry Cell Biology, 39, 44-84, 2007.
  • [3] Percival, M., Antioxidants, Clinical Nutrition İnsights. 10: 1–4, 1998.
  • [4] Frey, F.M, Meyers, R., Antibacterial activity of traditional medicinal plants used by Haudenosaunee peoples of New York State, BMC Complementary and Alternative Medicine 2010, 10:64.
  • [5] Benli, M., Yigit Kayhan, N., Geven, F., Güney, K., Bingöl, M.U., Antimicrobial activity of endemic Digitalis lamarckii Ivan from Turkey, Indian Journal of Experimental Biology, 47, 218–221, 2009.
  • [6] Tusevski, O., Kostovska, A, Iloska, A, Trajkovska, L, Simic, S.G., Phenolic production and antioxidant properties of some Macedonian medicinal plants, Central European Journal of Biology, 9, 888-900, 2014.
  • [7] Katanić, J., Ceylan, R., Matić, S., Boroja, T., Zengin, G., Aktumsek, A., Mihailović, V., Stanić S., Novel perspectives on two Digitalis species: Phenolic profile, bioactivity, enzyme inhibition, and toxicological evaluation, South African Journal of Botany, 109:50–57, 2017.
  • [8] Adom, M.B., Taber, M., Mutalabisi, M.F, Amri, M.S., Kudos, M.B.A., Sulaiman, M.W.A.W., Sengupta P., Susanti D., Chemical constituents and medical benefits of Plantago major, Biomedicine &Pharmacotherapy, 96:348-360, 2017.
  • [9] Kaska, A., Çiçek, M., Mammadov, R., Biological activities, phenolic constituents and mineral element analysis of two endemic medicinal plants from Turkey: Nepeta italica subsp. cadmea and Teucrium sandrasicum, South African Journal of Botany, 124, 63–70, 2019.
  • [10] Kaska, A., Deniz, N., Cicek, M., Mammadov, R., Evaluation of antioxidant properties, phenolic compounds, anthelmintic, and cytotoxic activities of various extracts isolated from Nepeta cadmea: an endemic plant for Turkey, Journal of Food Science, 83, 1552–1559, 2018.
  • [11] Caponio, F., Alloggio, V., Gomes, T., Phenolic compounds of virgin olive oil: influence of paste preparation techniques. Food Chemistry, 64, 203–209, 1999.
  • [12] Kaska, A., Mammadov, R., Antioxidant properties, proximate analysis, phenolic compounds, anthelmintic and cytotoxic screening of Teucrium sandrasicum, an endemic plant for Turkey, Italian Journal of Food Science, 31,332-346, 2019.
  • [13] Meyer, B.N., Ferrigni, N.R., Putnam, J.E., Jacobsen, L.B., Nichols, D.E., McLaughlin, J.L., Brine shrimp: a convenient general bioassay for active plant constituents. Planta Medica. 45, 31–34, 1982.
  • [14] Peterson, G.L., Review of the folin phenol protein quantitation method of lowry, rosebrough, farr, randall, Analytical Biochemisrty, 100(2), 201-220, 1979.
  • [15] Slinkard, K., Singleton, V.L., Total Phenol Analysis: Automation and Comparison with Manual Methods, American Journal of Enology and Viticulture. 28, 49-55, 1977.
  • [16] Liu, H., Song, Y., Zhang, X., Determination of total flavonoids in Leek by AlCl3 colorimetric assay, Chemical Engineering Transactions, 59, 775-780, 2017.
  • [17] Xu, J., Tong, C., Fu, Q., Guo, K., Shi, S., Xiao, Y., Comprehensive polyphenol profile of Plantago depressa using high-speed countercurrent chromatography off-line with high-performance liquid chromatography-diode array detector-quadrupole time-of-flight tandem mass spectrometry, eFOOD, 1-12, 2019.
  • [18] Martinez-Valverde, I., Periago, M.J., Ros, G., Significado nutricional de los compuestos fenolicos de la dieta, Archivos Latinoamericanos de Nutricion, 50 (1), 5-18, 2000.
  • [19] Santos-Sanchez, N.F., Salas-Coronado, R., Vaillanueva-Canongo, C., Hernandez-Carlos, B. Chapter: Antioxidant compounds and their antioxidant mechanism, Antioxidants, 1-28, 2019.
  • [20] Paran, E., Novack, V., Engelhard, Y.N., Hazan-Halevy, I., The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients, Cardiovascular Drugs and Therapy, 23 (2),145-151, 2009.
  • [21] Yoshida, M., Sakai, T., Hosokawa, N., Marui, N., Matsumoto, K., Fujioka, A. et al., The effect of quercitin on cell cycle progression and growth of human gastric cancer cells, FEBS Letters, 260 (1), 10-13, 1990.
  • [22] Ho, C.T., Phenolic compounds in foods. Phenolic Compounds in Food and Their Effects on Health II. Chapter I, pp.2-7, 1992.
  • [23] Prieto, P., Pineda, M., Aguilar, M., Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E, Analytical Biochemistry, 269, 337–341, 1999.
  • [24] Nickavar, B., Esbati, N., Evaluation of the Antioxidant Capacity and Phenolic Content of Three Thymus Species, Journal of Acupuncture and Meridian Studies, 5(3), 119-125, 2012.
  • [25] Sultana, B., Anwar, F., Ashraf, M., Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts, Molecules, 14, 2167-2180, 2009.
  • [26] Pérez-Jiménez, J., Saura-Calixto, F., Effect of solvent and certain food constituents on different antioxidant capacity assays, Food Research International, 39, 791– 800, 2006.
  • [27] Lee, K.J., Oh, Y.C., Cho, W.K., Ma, J.Y., Antioxidant and Anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay, Evidence-Based Complemetary and Alternative Medicine. 1-13, 2015.
  • [28] Sujarwo, W., Keim, A.P., Spondias pinnata (L.f.) Kurz. (Anacardiaceae): Profiles and zpplications to diabetes, Chapter 27-Bioactive Food as Dietary Intervantions for Diabetes. 395-405, 2019.
  • [29] Burda, S., Oleszek, W., Antioxidant and antiradical activities of flavonoids, Journal of Agricultural and Food Chemistry, 49 (6), 2774-9, 2001.
  • [30] Zin, Z.M, Abdul, A., Antioxidative activity of extracts from Mengkudu (Morinda citrifolia L.) root, fruit and leaf, Food Chemistry, 78, 227-231, 2002.
  • [31] Nimse, S.B, Pal, D., Free radicals natural antioxidants and their reaction mechanism, RSC Advances, 5, 2015.
  • [32] Dean, R.T, Fu, S., Stocker, R,, Davies, M., Biochemisrty and pathology of radical-mediated protein oxidation, Biochemisrty Journal, 324, 1-18, 1997.
  • [33] Rohman, A., Riyanto, S., Yuniarti, N., Saputra, W.R, Utami, R., Antioxidant activity total phenolic and total flavonoid of extracts and fractions of red fruit (Pandanus conoideus Lam.) International Food Research Journal, 17, 97-106, 2010.
  • [34] Zheng, W., Wang, Y.S., Antioxidant activity and phenolic compounds in selected herbs, Journal of Agricultural and Food Chemistry, 49, 5165-5170, 2001.
  • [35] Mohan, S.C., Balamurugan, V., Salini, S.T., Rekha, R., Metal ion chelating activity and hydrogen peroxide scavenging activity of medicinal plant Kalanchoe pinnata, Journal of Chemical and Pharmaceutical Research, 4, 197-202, 2012.
  • [36] Kumar, C.S., Loh, W.S., Ooi, C.W., Quah, C.K., Fun, H.K., Structural correlation of some heterocyclic chalcone analogues and evaluation of their antioxidant potential, Molecules, 18 (10), 11996-12011, 2013.
  • [37] Ksouri, R., Megdiche, W., Falleh, H., Trabelsi, N., Boulaaba, M., Smaoui, A., Abdelly, C., Influence of biological, environmental and technical factors on phenolic content and antioxidant activities of Tunisian halophytes, Compes Rendus Biologie, 31, 865-873, 2008.
  • [38] Hamidi, M.R., Jovanova, B., Panovska, T.K., Toxicological evaluation of the plant products using Brine Shrimp (Artema salina L.) model, Macedonian pharmaceutical bulletin, 60(1), 9-18, 2014.
  • [39] Gadir, S.A., Assessment of bioactivity of some Sudanese medicinal plants using Brine Shrimp (Artemia salina) lethality assay. Journal of Chemical and Pharmaceutical Research, 4, 5145-5148, 2012.
  • [40] Naidu, J.R., Ismail, R., Sasidharan, S., Acute oral toxicity and Brine shrimp lethality of methanol extracts of Mentha spicata L. (Lamiaceae), Tropical Journal of Pharmaceutical Research, 13, 101-107, 2014.

A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis ferruginea L. subsp. ferruginea

Year 2020, Volume: 10 Issue: 1, 133 - 145, 25.06.2020
https://doi.org/10.37094/adyujsci.714081

Abstract

    Digitalis plants have different biological actions, including antioxidant and antimicrobial activities. In addition, some members of this genus are used in traditional Turkish medicine as diuretics and tonics. The purpose of the present study is to compare the antioxidant, toxic activity and phenolic profile of two extracts of D. ferruginea L. subsp. ferruginea. The radical scavenging capacities in the hydromethanolic extract were higher than the hydroethanolic extract. The same extract was effective in total antioxidant (β-carotene, 83.75% and phosphomolybdenum 111.5 µg/mg) and metal chelating activities. The hydromethanolic extract (75.91 mgGAEs/g) exhibited higher phenolic content than hydroethanolic extract (70 mgGAEs/g). There were no statistical differences between the flavonoid and tannin contents of the extracts. The HPLC results determined major phenolics: 2,5 dihydroxybenzoic, vanillic and caffeic acid. In addition, this plant is also rich in polyphenolic content as well as toxic activity. The present data could provide significant information regarding its potential use in the pharmaceutical industry.

References

  • [1] Ahmed, D., Khan, M.M., Saeed, R., Comperative analysis of phenolics, flavonoids and antioxidant and antibacterial potential of methanolic, hexanic and aqueous extracts from Adiantum caudatum leave, Antioxidants. 4, 394-409, 2015.
  • [2] Valko, M., Leibfritz, D., Moncol, J., Cronn, M.T.D., Mazur, M., Telser, J., Free redicals and antioxidants in normal physiological functions and human disease, International Journal of Biochemistry Cell Biology, 39, 44-84, 2007.
  • [3] Percival, M., Antioxidants, Clinical Nutrition İnsights. 10: 1–4, 1998.
  • [4] Frey, F.M, Meyers, R., Antibacterial activity of traditional medicinal plants used by Haudenosaunee peoples of New York State, BMC Complementary and Alternative Medicine 2010, 10:64.
  • [5] Benli, M., Yigit Kayhan, N., Geven, F., Güney, K., Bingöl, M.U., Antimicrobial activity of endemic Digitalis lamarckii Ivan from Turkey, Indian Journal of Experimental Biology, 47, 218–221, 2009.
  • [6] Tusevski, O., Kostovska, A, Iloska, A, Trajkovska, L, Simic, S.G., Phenolic production and antioxidant properties of some Macedonian medicinal plants, Central European Journal of Biology, 9, 888-900, 2014.
  • [7] Katanić, J., Ceylan, R., Matić, S., Boroja, T., Zengin, G., Aktumsek, A., Mihailović, V., Stanić S., Novel perspectives on two Digitalis species: Phenolic profile, bioactivity, enzyme inhibition, and toxicological evaluation, South African Journal of Botany, 109:50–57, 2017.
  • [8] Adom, M.B., Taber, M., Mutalabisi, M.F, Amri, M.S., Kudos, M.B.A., Sulaiman, M.W.A.W., Sengupta P., Susanti D., Chemical constituents and medical benefits of Plantago major, Biomedicine &Pharmacotherapy, 96:348-360, 2017.
  • [9] Kaska, A., Çiçek, M., Mammadov, R., Biological activities, phenolic constituents and mineral element analysis of two endemic medicinal plants from Turkey: Nepeta italica subsp. cadmea and Teucrium sandrasicum, South African Journal of Botany, 124, 63–70, 2019.
  • [10] Kaska, A., Deniz, N., Cicek, M., Mammadov, R., Evaluation of antioxidant properties, phenolic compounds, anthelmintic, and cytotoxic activities of various extracts isolated from Nepeta cadmea: an endemic plant for Turkey, Journal of Food Science, 83, 1552–1559, 2018.
  • [11] Caponio, F., Alloggio, V., Gomes, T., Phenolic compounds of virgin olive oil: influence of paste preparation techniques. Food Chemistry, 64, 203–209, 1999.
  • [12] Kaska, A., Mammadov, R., Antioxidant properties, proximate analysis, phenolic compounds, anthelmintic and cytotoxic screening of Teucrium sandrasicum, an endemic plant for Turkey, Italian Journal of Food Science, 31,332-346, 2019.
  • [13] Meyer, B.N., Ferrigni, N.R., Putnam, J.E., Jacobsen, L.B., Nichols, D.E., McLaughlin, J.L., Brine shrimp: a convenient general bioassay for active plant constituents. Planta Medica. 45, 31–34, 1982.
  • [14] Peterson, G.L., Review of the folin phenol protein quantitation method of lowry, rosebrough, farr, randall, Analytical Biochemisrty, 100(2), 201-220, 1979.
  • [15] Slinkard, K., Singleton, V.L., Total Phenol Analysis: Automation and Comparison with Manual Methods, American Journal of Enology and Viticulture. 28, 49-55, 1977.
  • [16] Liu, H., Song, Y., Zhang, X., Determination of total flavonoids in Leek by AlCl3 colorimetric assay, Chemical Engineering Transactions, 59, 775-780, 2017.
  • [17] Xu, J., Tong, C., Fu, Q., Guo, K., Shi, S., Xiao, Y., Comprehensive polyphenol profile of Plantago depressa using high-speed countercurrent chromatography off-line with high-performance liquid chromatography-diode array detector-quadrupole time-of-flight tandem mass spectrometry, eFOOD, 1-12, 2019.
  • [18] Martinez-Valverde, I., Periago, M.J., Ros, G., Significado nutricional de los compuestos fenolicos de la dieta, Archivos Latinoamericanos de Nutricion, 50 (1), 5-18, 2000.
  • [19] Santos-Sanchez, N.F., Salas-Coronado, R., Vaillanueva-Canongo, C., Hernandez-Carlos, B. Chapter: Antioxidant compounds and their antioxidant mechanism, Antioxidants, 1-28, 2019.
  • [20] Paran, E., Novack, V., Engelhard, Y.N., Hazan-Halevy, I., The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients, Cardiovascular Drugs and Therapy, 23 (2),145-151, 2009.
  • [21] Yoshida, M., Sakai, T., Hosokawa, N., Marui, N., Matsumoto, K., Fujioka, A. et al., The effect of quercitin on cell cycle progression and growth of human gastric cancer cells, FEBS Letters, 260 (1), 10-13, 1990.
  • [22] Ho, C.T., Phenolic compounds in foods. Phenolic Compounds in Food and Their Effects on Health II. Chapter I, pp.2-7, 1992.
  • [23] Prieto, P., Pineda, M., Aguilar, M., Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E, Analytical Biochemistry, 269, 337–341, 1999.
  • [24] Nickavar, B., Esbati, N., Evaluation of the Antioxidant Capacity and Phenolic Content of Three Thymus Species, Journal of Acupuncture and Meridian Studies, 5(3), 119-125, 2012.
  • [25] Sultana, B., Anwar, F., Ashraf, M., Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts, Molecules, 14, 2167-2180, 2009.
  • [26] Pérez-Jiménez, J., Saura-Calixto, F., Effect of solvent and certain food constituents on different antioxidant capacity assays, Food Research International, 39, 791– 800, 2006.
  • [27] Lee, K.J., Oh, Y.C., Cho, W.K., Ma, J.Y., Antioxidant and Anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay, Evidence-Based Complemetary and Alternative Medicine. 1-13, 2015.
  • [28] Sujarwo, W., Keim, A.P., Spondias pinnata (L.f.) Kurz. (Anacardiaceae): Profiles and zpplications to diabetes, Chapter 27-Bioactive Food as Dietary Intervantions for Diabetes. 395-405, 2019.
  • [29] Burda, S., Oleszek, W., Antioxidant and antiradical activities of flavonoids, Journal of Agricultural and Food Chemistry, 49 (6), 2774-9, 2001.
  • [30] Zin, Z.M, Abdul, A., Antioxidative activity of extracts from Mengkudu (Morinda citrifolia L.) root, fruit and leaf, Food Chemistry, 78, 227-231, 2002.
  • [31] Nimse, S.B, Pal, D., Free radicals natural antioxidants and their reaction mechanism, RSC Advances, 5, 2015.
  • [32] Dean, R.T, Fu, S., Stocker, R,, Davies, M., Biochemisrty and pathology of radical-mediated protein oxidation, Biochemisrty Journal, 324, 1-18, 1997.
  • [33] Rohman, A., Riyanto, S., Yuniarti, N., Saputra, W.R, Utami, R., Antioxidant activity total phenolic and total flavonoid of extracts and fractions of red fruit (Pandanus conoideus Lam.) International Food Research Journal, 17, 97-106, 2010.
  • [34] Zheng, W., Wang, Y.S., Antioxidant activity and phenolic compounds in selected herbs, Journal of Agricultural and Food Chemistry, 49, 5165-5170, 2001.
  • [35] Mohan, S.C., Balamurugan, V., Salini, S.T., Rekha, R., Metal ion chelating activity and hydrogen peroxide scavenging activity of medicinal plant Kalanchoe pinnata, Journal of Chemical and Pharmaceutical Research, 4, 197-202, 2012.
  • [36] Kumar, C.S., Loh, W.S., Ooi, C.W., Quah, C.K., Fun, H.K., Structural correlation of some heterocyclic chalcone analogues and evaluation of their antioxidant potential, Molecules, 18 (10), 11996-12011, 2013.
  • [37] Ksouri, R., Megdiche, W., Falleh, H., Trabelsi, N., Boulaaba, M., Smaoui, A., Abdelly, C., Influence of biological, environmental and technical factors on phenolic content and antioxidant activities of Tunisian halophytes, Compes Rendus Biologie, 31, 865-873, 2008.
  • [38] Hamidi, M.R., Jovanova, B., Panovska, T.K., Toxicological evaluation of the plant products using Brine Shrimp (Artema salina L.) model, Macedonian pharmaceutical bulletin, 60(1), 9-18, 2014.
  • [39] Gadir, S.A., Assessment of bioactivity of some Sudanese medicinal plants using Brine Shrimp (Artemia salina) lethality assay. Journal of Chemical and Pharmaceutical Research, 4, 5145-5148, 2012.
  • [40] Naidu, J.R., Ismail, R., Sasidharan, S., Acute oral toxicity and Brine shrimp lethality of methanol extracts of Mentha spicata L. (Lamiaceae), Tropical Journal of Pharmaceutical Research, 13, 101-107, 2014.
There are 40 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Biology
Authors

Arzu Kaska 0000-0002-0166-1818

Publication Date June 25, 2020
Submission Date April 3, 2020
Acceptance Date June 6, 2020
Published in Issue Year 2020 Volume: 10 Issue: 1

Cite

APA Kaska, A. (2020). A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis ferruginea L. subsp. ferruginea. Adıyaman University Journal of Science, 10(1), 133-145. https://doi.org/10.37094/adyujsci.714081
AMA Kaska A. A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis ferruginea L. subsp. ferruginea. ADYU J SCI. June 2020;10(1):133-145. doi:10.37094/adyujsci.714081
Chicago Kaska, Arzu. “A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis Ferruginea L. Subsp. Ferruginea”. Adıyaman University Journal of Science 10, no. 1 (June 2020): 133-45. https://doi.org/10.37094/adyujsci.714081.
EndNote Kaska A (June 1, 2020) A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis ferruginea L. subsp. ferruginea. Adıyaman University Journal of Science 10 1 133–145.
IEEE A. Kaska, “A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis ferruginea L. subsp. ferruginea”, ADYU J SCI, vol. 10, no. 1, pp. 133–145, 2020, doi: 10.37094/adyujsci.714081.
ISNAD Kaska, Arzu. “A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis Ferruginea L. Subsp. Ferruginea”. Adıyaman University Journal of Science 10/1 (June 2020), 133-145. https://doi.org/10.37094/adyujsci.714081.
JAMA Kaska A. A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis ferruginea L. subsp. ferruginea. ADYU J SCI. 2020;10:133–145.
MLA Kaska, Arzu. “A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis Ferruginea L. Subsp. Ferruginea”. Adıyaman University Journal of Science, vol. 10, no. 1, 2020, pp. 133-45, doi:10.37094/adyujsci.714081.
Vancouver Kaska A. A Comparative Study of Different Solvents on the Toxic and Antioxidant Properties of Digitalis ferruginea L. subsp. ferruginea. ADYU J SCI. 2020;10(1):133-45.

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