<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article  article-type="research-article"        dtd-version="1.4">
            <front>

                <journal-meta>
                                    <journal-id></journal-id>
            <journal-title-group>
                                                                                    <journal-title>Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi</journal-title>
            </journal-title-group>
                            <issn pub-type="ppub">1304-6187</issn>
                                                                                                        <publisher>
                    <publisher-name>Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesi</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.20492/aeahtd.1483471</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Haematology</subject>
                                                            <subject>​Internal Diseases</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Hematoloji</subject>
                                                            <subject>İç Hastalıkları</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <trans-title-group xml:lang="en">
                                    <trans-title>Correlation Between Vitamin D and Ferritin, Vitamin B12, Homocysteine, and Methylmalonic acid</trans-title>
                                </trans-title-group>
                                                                                                                                                                                                <article-title>D vitamini ile Vitamin B12, Metilmalonik Asit, Homosistein ve Ferritin Düzeyleri Arasındaki İlişki</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0003-4663-1898</contrib-id>
                                                                <name>
                                    <surname>Alanlı</surname>
                                    <given-names>Recep</given-names>
                                </name>
                                                                    <aff>ANKARA EĞİTİM VE ARAŞTIRMA HASTANESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-7101-0503</contrib-id>
                                                                <name>
                                    <surname>Kılıç</surname>
                                    <given-names>Mustafa Kemal</given-names>
                                </name>
                                                                    <aff>ANKARA EĞİTİM VE ARAŞTIRMA HASTANESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-7924-5478</contrib-id>
                                                                <name>
                                    <surname>Şeneş</surname>
                                    <given-names>Mehmet</given-names>
                                </name>
                                                                    <aff>ANKARA EĞİTİM VE ARAŞTIRMA HASTANESİ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20250504">
                    <day>05</day>
                    <month>04</month>
                    <year>2025</year>
                </pub-date>
                                        <volume>58</volume>
                                        <issue>1</issue>
                                        <fpage>7</fpage>
                                        <lpage>10</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20240514">
                        <day>05</day>
                        <month>14</month>
                        <year>2024</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20250303">
                        <day>03</day>
                        <month>03</month>
                        <year>2025</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2003, Medical Journal of Ankara Training and Research Hospital</copyright-statement>
                    <copyright-year>2003</copyright-year>
                    <copyright-holder>Medical Journal of Ankara Training and Research Hospital</copyright-holder>
                </permissions>
            
                                                                                                <trans-abstract xml:lang="en">
                            <p>Aim: It is not well-known whether there is an association between vitamin D and other vitamin levels. In this study, potential interrelation between vitamin D and folate, ferritin, vitamin B12, homocysteine, and methylmalonic acid levels was examined. Material and Methods: Laboratory results of 189 adult patients (18-65 years old) who admitted to our Internal Medicine outpatient clinic between November 2022 to April 2023 were retrospectively retrieved from hospital registry. Participants younger than 18 and older than 65 years old, with a history of vitamin D replacement within 3 months, diagnosed with cancer, acute infection, pregnancy, renal or hepatic disease, malabsorption like Celiac or inflammatory bowel disease were excluded.Results: There was a positive correlation between vitamin D and both hemoglobin and ferritin (r=0.219 p=0.003 and r=0.262 p</p></trans-abstract>
                                                                                                                                    <abstract><p>Amaç: D vitamini ile diğer vitamin düzeyleri arasında bir ilişki olup olmadığı tam olarak bilinmemektedir. Bu çalışmada D vitamini ile folat, ferritin, B12 vitamini, homosistein ve metilmalonik asit (MMA) düzeyleri arasındaki potansiyel ilişki incelenmiştir.Gereç ve Yöntemler: Kasım 2022 ile Nisan 2023 tarihleri arasında Dahiliye polikliniğimize başvuran 189 yetişkin hastanın (18-65 yaş) laboratuvar sonuçları hastane kayıtlarından retrospektif olarak elde edildi. 18 yaş altı ve 65 yaş üstü, son 3 ay içinde D vitamini replasman öyküsü olan, kanser, akut enfeksiyon, gebelik, böbrek veya karaciğer hastalığı, Çölyak hastalığı gibi malabsorbsiyon veya inflamatuar barsak hastalığı tanısı alan katılımcılar çalışma dışı bırakıldı.Bulgular: D vitamini ile hemoglobin ve ferritin arasında pozitif korelasyon vardı (sırasıyla r=0,219 p=0,003 ve r=0,262 p</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>Ferritin</kwd>
                                                    <kwd>  homosistein</kwd>
                                                    <kwd>  metilmalonik asit</kwd>
                                                    <kwd>  vitamin B12</kwd>
                                                    <kwd>  vitamin D</kwd>
                                            </kwd-group>
                            
                                                <kwd-group xml:lang="en">
                                                    <kwd>Ferritin</kwd>
                                                    <kwd>  homocysteine</kwd>
                                                    <kwd>  methylmalonic acid</kwd>
                                                    <kwd>  vitamin B12</kwd>
                                                    <kwd>  vitamin D</kwd>
                                            </kwd-group>
                                                                                                                                    <funding-group specific-use="FundRef">
                    <award-group>
                                                    <funding-source>
                                <named-content content-type="funder_name">yok</named-content>
                            </funding-source>
                                                                    </award-group>
                </funding-group>
                                </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1. Langan RC, Goodbred AJ. Vitamin B12 Deficiency: Recognition
and Management. Am Fam Physician. 2017;96(6):384-89.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2. Carlberg C. Vitamin D: A Micronutrient Regulating Genes. Curr
Pharm Des. 2019;25(15):1740-46. doi: 10.2174/138161282566619
0705193227.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3. Konuksever D, Yücel Karakaya SP. Evaluation of correlation
between vitamin D with vitamin B12 and folate in children. Nutrition.
2022;99-100:111683. doi: 10.1016/j.nut.2022.111683</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4. Rahman A, Al-Taiar A, Shaban L, Al-Sabah R, Mojiminiyi O. Plasma
25-hydroxyvitamin D is positively associated with folate and vitamin
B12 levels in adolescents. Nutr Res. 2020;79:87-99. doi: 10.1016/j.
nutres.2020.06.003.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">5. Brandsch C, Zibolka J, Frommhagen M, Lehmann U, Dierkes J,
Kühne H, et al. Vitamin D is not linked to folate status and mRNA
expression of intestinal proton-coupled folate transporter. Eur J Nutr.
2014;53(4):1115-22. doi: 10.1007/s00394-013-0614-7.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">6. Kullak-Ublick GA, Gubler C, Spanaus K, Ismair MG, Claro da Silva
T, Jetter A. No major effects of vitamin D3 (1,25 dihydroxyvitamin D3)
on absorption and pharmacokinetics of folic acid and fexofenadine in
healthy volunteers. Eur J Clin Pharmacol. 2016;72(7):797-805. doi:
10.1007/s00228-016-2050-0.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">7. Nur-Eke R, Özen M. The Relationship between Vitamin D Levels
and Iron Deficiency and Anemia in Adults Applied for Periodic
Medical Examination. Clin Lab. 2020;66(6). doi: 10.7754/Clin.
Lab.2019.190918.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">8. Monlezun DJ, Camargo CA Jr, Mullen JT, Quraishi SA. Vitamin D
Status and the Risk of Anemia in Community-Dwelling Adults: Results
from the National Health and Nutrition Examination Survey
2001-2006. Medicine (Baltimore). 2015;94(50):e1799. doi: 10.1097/
MD.0000000000001799.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">9. Klee GG. Cobalamin and folate evaluation: measurement of methylmalonic
acid and homocysteine vs vitamin B(12) and folate. Clin
Chem. 2000;46(8 Pt 2):1277-83.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">10. Lee YA, Kang SG, Song SW, Kim SH. Association between Homocysteine
and Vitamin D Levels in Asymptomatic Korean Adults.
Nutrients. 2024;16(8):1155. doi: 10.3390/nu16081155.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">11. Amer M, Qayyum R. The relationship between 25-hydroxyvitamin
D and homocysteine in asymptomatic adults. J Clin Endocrinol Metab.
2014;99(2):633-8. doi: 10.1210/jc.2013-3262</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">12. Solomon LR. Functional cobalamin (vitamin B12) deficiency:
role of advanced age and disorders associated with increased oxidative
stress. Eur J Clin Nutr. 2015;69(6):687-92. doi: 10.1038/
ejcn.2014.272.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">13. Lac PT, Choi K, Liu IA, Meguerditchian S, Rasgon SA, Sim JJ.
The effects of changing vitamin D levels on anemia in chronic kidney
disease patients: a retrospective cohort review. Clin Nephrol.
2010;74(1):25-32. doi: 10.5414/cnp74025.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">14. Norman AW. Minireview: vitamin D receptor: new assignments for
an already busy receptor. Endocrinology. 2006;147(12):5542-8. doi:
10.1210/en.2006-0946.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">15. Bacchetta J, Zaritsky JJ, Sea JL, Chun RF, Lisse TS, Zavala K, et
al. Suppression of iron-regulatory hepcidin by vitamin D. J Am Soc
Nephrol. 2014;25(3):564-72. doi: 10.1681/ASN.2013040355.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">16. Zughaier SM, Alvarez JA, Sloan JH, Konrad RJ, Tangpricha V. The
role of vitamin D in regulating the iron-hepcidin-ferroportin axis in
monocytes. J Clin Transl Endocrinol. 2014;1(1):19-25. doi: 10.1016/j.
jcte.2014.01.003.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">17. Shimmi SC, Eldosouky HF, Hossain Parash MT, Wan Saudi WS.
Probability of Concurrent Deficiency of Vitamin D and Iron in Hypothyroidism:
A Cross-Sectional Study. Cureus. 2023;15(4):e37152. doi:
10.7759/cureus.37152.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">18. Hitesh T, Khatuja R, Agrawal P, Dhamnetiya D, Jha RP, Renjhen
P. Unlocking the mystery of the role of Vitamin D in iron deficiency
anemia in antenatal women: a case control study in a tertiary care
hospital in New Delhi. BMC Pregnancy Childbirth. 2023;23(1):749.
doi: 10.1186/s12884-023-06047-w.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">19. Liu T, Zhong S, Liu L, Liu S, Li X, Zhou T,et al. Vitamin D deficiency
and the risk of anemia: a meta-analysis of observational studies. Ren
Fail. 2015;37(6):929-34. doi: 10.3109/0886022X.2015.1052979.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">20. Karabayir N, Teber BG, Dursun HK, Pehlivan LS. Is There An Association
Between Vitamin B12 Level and Vitamin D Status in Children?
J Pediatr Hematol Oncol. 2022;44(3):e677-e681. doi: 10.1097/
MPH.0000000000002329.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">21. Plant AS, Tisman G. Frequency of combined deficiencies of vitamin
D and holotranscobalamin in cancer patients. Nutr Cancer.
2006;56(2):143-8. doi: 10.1207/s15327914nc5602_4.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">22. Singh K, Gandhi S, Batool R. A Case-Control Study of the Association
between Vitamin D Levels and Gastric Incomplete Intestinal
Metaplasia. Nutrients. 2018;10(5):629. doi: 10.3390/nu10050629.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">23. Delgado JA, Pastor García MI, Márquez Jiménez N, Costa Petit
G, Regís Perelló A, Robles J,et al. Functional vitamin B12 deficiency:
Improving methylmalonic acid reference intervals in urine. Clin Chim
Acta. 2023;544:117334. doi: 10.1016/j.cca.2023.117334.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">24. Devalia V, Hamilton MS, Molloy AM; British Committee for Standards
in Haematology. Guidelines for the diagnosis and treatment of
cobalamin and folate disorders. Br J Haematol. 2014;166(4):496-
513. doi: 10.1111/bjh.12959.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">25. Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of
cobalamin deficiency: II. Relative sensitivities of serum cobalamin,
methylmalonic acid, and total homocysteine concentrations. Am J
Hematol. 1990;34(2):99-107. doi: 10.1002/ajh.2830340205</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">26. Guo J, Liu X, Wang Z, Lu R, Liu Y, Zhang Y,et al. Methylmalonic
acid, vitamin B12, and mortality risk in patients with preexisting coronary
heart disease: a prospective cohort study. Nutr J. 2023;22(1):63.
doi: 10.1186/s12937-023-00900-6.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">27. Hooshmand B, Appold F, Fissler P, Perneczky R, Otto M, Tumani
H, et al. Markers of Vitamin B12 Status in Relation to Cerebrospinal
Fluid Biomarkers of Alzheimer&#039;s Disease and Cognitive Performance.
Ann Neurol. 2023;94(2):223-231. doi: 10.1002/ana.26673.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
