Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi 1304-6187 Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesi 10.20492/aeahtd.893090 Clinical Sciences Klinik Tıp Bilimleri Hipotalamik hamartoma bağlı santral puberte prekoks ve faktör 7 eksikliği birlikteliği https://orcid.org/0000-0001-8763-525X Selver Muhammed Burak istanbul Üniversitesi Sağlık Bilimleri Enstitüsü Çocuk Sağlığı Enstitüsü Sosyal Pediatri Doktora Programı ,İstanbul,Türkiye https://orcid.org/0000-0002-6700-5346 Selver Eklioğlu Beray NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ Atabek Mehmet NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ https://orcid.org/0000-0002-3064-4646 Tokgöz Hüseyin NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ https://orcid.org/0000-0003-4695-7046 Çalışkan Ümran NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ 01 01 2022 54 3 501 504 03 08 2021 04 11 2021 Copyright © 2003, Medical Journal of Ankara Training and Research Hospital 2003 Medical Journal of Ankara Training and Research Hospital

Hipotalamik hamartom konjenital neoplastik olmayan tümör benzeri bir lezyondur. Santral puberte prekoksun santral sinir sistemi ile ilgili yaygın görülen organik sebeplerindendir. Bu olgu hipotalamik hamartoma bağlı küçük yaşta santral puberte prekoks görülmesi ve beraberinde faktör yedi eksikliğinin eşlik etmesi nedeniyle sunulmuştur.

 puberte prekoks hipotalamik hamartom faktör yedi eksikliği 1-Soriano-Guillén L, Argente J. Central precocious puberty, functional and tumor-related. Best Pract Res Clin Endocrinol Metab. 2019 Jun;33(3):101262. 2-Aguirre RS, Eugster EA. Central precocious puberty: From genetics to treatment. Best Pract Res Clin Endocrinol Metab. 2018 Aug;32(4):343-354. 3- Qasim BA, Mohammed AA. Hamartoma of hypothalamus presented as precocious puberty and epilepsy in a 10-year-old girl. Int J Surg Case Rep. 2020;77:170-173. doi: 10.1016/j.ijscr.2020.10.065 4- Yoon DY, Kim JH. An 11-month-old girl with central precocious puberty caused by hypothalamic hamartoma. Ann Pediatr Endocrinol Metab. 2016 Dec;21(4):235-239 5- Judge DM, Kulin HE, Page R, Santen R, Trapukdi S. Hypothalamic hamartoma: a source of luteinizing-hormone-releasing factor in precocious puberty. N Engl J Med. 1977 Jan 6;296(1):7-10. 6- Striano S, Striano P, Sarappa C, Boccella P. The clinical spectrum and natural history of gelastic epilepsy-hypothalamic hamartoma syndrome. Seizure. 2005 Jun;14(4):232-9. 7- Nguyen D, Singh S, Zaatreh M, Novotny E, Levy S, Testa F, Spencer SS. Hypothalamic hamartomas: seven cases and review of the literature. Epilepsy Behav. 2003 Jun;4(3):246-58. 8- Unger F, Schröttner O, Haselsberger K, Körner E, Ploier R, Pendl G. Gamma knife radiosurgery for hypothalamic hamartomas in patients with medically intractable epilepsy and precocious puberty. Report of two cases. J Neurosurg. 2000 Apr;92(4):726-31. 9- Alves C, Barbosa V, Machado M. Giant hypothalamic hamartoma: case report and literature review. Childs Nerv Syst. 2013 Mar;29(3):513-6. 10- Kotwal N, Yanamandra U, Menon AS, Nair V. Central precocious puberty due to hypothalamic hamartoma in a six-month-old infant girl. Indian J Endocrinol Metab. 2012 Jul;16(4):627-30. 11- Roberts JC. Evaluation of Abnormal Bleeding in Children. Pediatr Ann. 2020 Jan 1;49(1):e36-e42. 12- Rodriguez V, Warad D. Pediatric Coagulation Disorders. Pediatr Rev. 2016 Jul;37(7):279-91.