ahi evran med j Ahi Evran Medical Journal 2619-9203 Kirsehir Ahi Evran University 10.46332/aemj.1756592 Nutritional Epidemiology Beslenme Epidemiyolojisi Üreme Çağındaki Kadınların İleri Glikasyon Son Ürün Düzeylerinin Menstrüel Semptomlar Üzerine Etkisi: Kesitsel bir Çalışma Effect of Advanced Glycation End Product Levels on Menstrual Symptoms in Women of Reproductive Age: A Cross-Sectional Study https://orcid.org/0000-0002-9445-4841 Öz Tuğba BEYKENT ÜNİVERSİTESİ https://orcid.org/0009-0008-3196-2575 Kaya Eda İSTANBUL ATLAS ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ https://orcid.org/0009-0002-0850-8127 Çeçen Ayşe Gül İSTANBUL SABAHATTİN ZAİM ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ 04 29 2026 10 1 158 167 08 01 2025 03 06 2026 Copyright © 2017, Ahi Evran Medical Journal 2017 Ahi Evran Medical Journal

Amaç: İleri glikasyon son ürünlerinin (AGEs) vücutta aşırı birikimi oksidatif stres ve inflamasyon aracılığıyla birçok olumsuz sağlık durumuna yol açabilmektedir. Menstrüel semptomlar; fizyolojik, biyolojik ve psikolojik pek çok faktörden etkilenmektedir. Bu çalışma, üreme çağındaki kadınlarda AGE düzeylerinin menstrüel semptomlar üzerindeki etkisini belirlemek amacıyla yapılmıştır.Araçlar ve Yöntem: Araştırma ilişki arayıcı ve kesitsel tiptedir. Mart-Eylül 2024 tarihleri arasında bir vakıf üniversitesinde gönüllü olarak katılmayı kabul eden ve araştırma kriterlerini karşılayan üreme çağındaki kadınlarla yürütülmüştür. Veriler Antro-pometrik ölçümler yapılarak, araştırmacılar tarafından hazırlanan Katılımcı Bilgi Formu, Menstrüasyon Semptom Ölçeği (MSÖ) ve cilt ileri glikasyon son ürün analiz cihazı ile toplanmıştır. Etik kurul ve kurum izni alınmış, katılımcılardan bilgilendirilmiş onam alınmıştır. Verilerin analizinde tanımlayıcı istatistikler, t-testi ve Spearman korelasyon analizi kullanılmış; anlamlılık düzeyi p

Purpose: Excessive accumulation of advanced glycation end products (AGEs) may contribute to adverse health conditions via oxidative stress and inflammation. Menstrual symptoms are influenced by physiological, biological, and psychological factors. This study aimed to determine the effect of AGE levels on menstrual symptoms in women of reproductive age.Materials and Methods: This correlational, cross-sectional study was conducted between March and September 2024 at a founda-tion university with women of reproductive age who voluntarily participated and met the inclusion criteria. Data were collected using anthropometric measurements, a Participant Information Form, the Menstrual Symptom Scale (MSS), and a skin AGE meas-urement device. Ethical approval and institutional permission were obtained, and written informed consent was secured. Descrip-tive statistics, independent samples t-test, and Spearman correlation analysis were used; statistical significance was set at p

 advanced glycation end products menstrual symptoms oxidative stress women’s health ileri glikasyon son ürünleri kadın sağlığı menstrüel semptom oksidatif stres 1. Ruiz HH, Ramasamy R, Schmidt AM. Advanced glycation end products: building on the concept of the "common soil" in metabolic disease. Endocrinology. 2020;161(1):bqz006. doi:10.1210/endocr/bqz006 2. Atzeni IM, van de Zande SC, Westra J, et al. The AGE Reader: a non-invasive method to assess long-term tissue damage. Methods. 2022;203:533-541. doi:10.1016/j.ymeth.2021.02.016 3. van Waateringe RP, Fokkens BT, Slagter SN, et al. Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population. Diabetologia. 2019;62(2):269-280. doi:10.1007/s00125-018-4769-x 4. Almengló C, Rodriguez-Ruiz E, Alvarez E, et al. Minimal invasive fluorescence methods to quantify advanced glycation end products (AGEs) in skin and plasma of humans. Methods. 2022;203:103-107. doi:10.1016/j.ymeth.2020.12.003 5. Kandaraki EA, Diamanti-Kandarakis E. Advanced glycation end products and polycystic ovarian syndrome. In: Dietary AGEs and Their Role in Health and Disease. CRC Press; 2017:137-146. doi:10.1201/9781315120041-14 6. Taşkın L. Obstetrics and Women's Health Nursing. 13th ed. Ankara: Akademisyen Medical Bookstore; 2016. 7. Şahin NH. Reproductive organ anatomy / physiology. In: Beji NK, ed. Women's Health and Diseases. 2nd ed. Istanbul: Nobel Medical Bookstores; 2017. 8. Derya YA, Erdemoğlu Ç, Özşahin Z. The status of menstrual symptoms in university students and its effect on quality of life. Acibadem Univ J Health Sci. 2019;10(2):176-181. doi:10.31067/0.2019.140 9. Tosun H, Şahin S. Evaluation of effectiveness of training in obese adolescent about nutrition, physical activity and menstrual symptoms on health lifestyle behaviours and menstrual symptoms. J Fac Health Sci Yobu. 2022;3(3):306-323. 10. Chesney MA, Tasto DL. The development of the menstrual symptom questionnaire. Behav Res Ther. 1975;13(4):237-244. doi:10.1016/0005-7967(75)90028-5 11. Negriff S, Dorn LD, Hillman JB, et al. The measurement of menstrual symptoms: factor structure of the menstrual symptom questionnaire in adolescent girls. J Health Psychol. 2009;14(7):899-908. doi:10.1177/1359105309340995 12. Güvenç G, Seven M, Akyüz A. Adaptation of Menstruation Symptom Scale into Turkish. TAF Prev Med Bull. 2014;13(5):367-374. doi:10.5455/pmb1-1378840527 13. Meerwaldt R, Graaf R, Oomen PHN, et al. Simple non-invasive assessment of advanced glycation end product accumulation. Diabetologia. 2004;47(7):1324-1330. doi:10.1007/s00125-004-1451-2 14. Meerwaldt R, Lutgers HL, Links TP, et al. Skin autofluorescence is a strong predictor of cardiac mortality in diabetes. Diabetes Care.2007;30(1):107-112. doi:10.2337/dc06-1391 15. Bos DC, De Ranitz-Greven WL, De Valk HW. Advanced glycation end products, measured as skin autofluorescence and diabetes complications: a systematic review. Diabetes Technol Ther. 2011;13(7):773-779. doi:10.1089/dia.2011.0034 16. Schoep ME, Nieboer TE, van der Zanden M, et al. The impact of menstrual symptoms on everyday life: a survey among 42,879 women. Am J Obstet Gynecol. 2019;220(6):569.e1-569.e7. doi:10.1016/j.ajog.2019.02.048 17. Akhtar Y, Malik S, Bhutta M, et al. A systematic review on the role of advanced glycation end-products (AGEs) in the development of PCOS. J Liaquat Uni Med Health Sci. 2024;23(4):279-286. doi:10.22442/jlumhs.2024.01101 18. Mouanness M, Nava H, Dagher C, et al. Contribution of advanced glycation end products to PCOS key elements: a narrative review. Nutrients. 2022;14(17):3578. doi:10.3390/nu14173578 19. Bahreiny SS, Ahangarpour A, Aghaei M. Circulating levels of advanced glycation end products in females with polycystic ovary syndrome: a meta-analysis. Reprod Dev Med. 2024;8(2):93-100. doi:10.1097/RD9.0000000000000089 20. Masho SW, Adera T, South-Paul J. Obesity as a risk factor for premenstrual syndrome. J Psychosom Obstet Gynaecol. 2005;26(1):33-39. doi:10.1080/01443610400023049 21. Uribarri J, Cai W, Sandu O, et al. Diet-derived advanced glycation end products are major contributors to the body’s AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci. 2005;1043(1):461-466. doi:10.1196/annals.1333.052