Case Report
Year 2021,
Volume: 20 Issue: 2, 123 - 126, 26.08.2021
Abstract
Kaposi sarkomu, insan herpes virüsü-8 ile ilişkili mezenkimal bir neoplazmdır. Genellikle birincil veya ikincil immün yetmezliği olan hastalarda bulunur. Azatioprin gibi immünomodülatör ilaçlar otoimmün hepatit hastalığında etkilidir, ancak bunların kullanımı toksisite endişeleri nedeniyle sınırlıdır. Burada, otoimmün hepatit hastalığı için azatioprin tedavisi alan ve sonrasında Kaposi sarkomu gelişen, insan immün yetmezlik virüsü negatif bir olguyu sunuyoruz.
Keywords
References
- 1) Mack CL, Adams D, Assis DN, et al. Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology 2020;72:671-722.
- 2) Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D. Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments. World J Gastroenterol 2017;23:6030-48.
- 3) Cetin B, Büyükberber S, Yilmaz IB, et al. Kaposi's sarcoma in patients with ulcerative colitis receiving immunosuppressive drugs: report of a case. Turk J Gastroenterol 2011;22:621-5.
- 4) Kilincalp S, Akıncı H, Hamamci M, Coşkun Y, Yüksel I. Kaposi's sarcoma developing in a HIV-negative Crohn's disease patient shortly after azathioprine and corticosteroid treatment. J Crohns Colitis 2014;8:558-9.
- 5) Saxena A, Netchiporouk E, Al-Rajaibi R, Billick R, Roshdy O. Iatrogenic Kaposi's sarcoma after immunosuppressive treatment for granulomatosis with polyangiitis (Wegener's). JAAD Case Rep 2015;1:71-3.
- 6) Cesarman E, Damania B, Krown SE, et al. Kaposi sarcoma. Nat Rev Dis Primers 2019;5:9.
- 7) Siegel JH, Janis R, Alper JC, et al. Disseminated visceral Kaposi’s sarcoma. Appearance after human renal homograft operation. JAMA 1969;207:1493-6.
- 8) Qunibi W, Al-Furayh O, Almeshari K, et al. Serologic association of human herpesvirus eight with posttransplant Kaposi's sarcoma in Saudi Arabia. Transplantation 1998;65:583-5.
- 9) Schneider JW, Dittmer DP. Diagnosis and Treatment of Kaposi Sarcoma. Am J Clin Dermatol 2017;18:529-39.
- 10) Trattner A, Hodak E, David M, Neeman A, Sandbank M. Kaposi's sarcoma with visceral involvement after intraarticular and epidural injections of corticosteroids. J Am Acad Dermatol 1993;29:890-4
Kaposi sarcoma development after azathioprine use in a patient with autoimmune hepatitis: A case report
Abstract
Kaposi sarcoma is a mesenchymal neoplasm associated with human herpes virus-8. It is usually found in patients who have primary or secondary immune deficiency. Immunomodulatory drugs such as azathioprine are effective in the treatment of autoimmune hepatitis. However, their use is limited due to toxicity concerns. We present an human immmunodeficiency virus-negative case who received azathioprine treatment for autoimmune hepatitis and subsequently developed Kaposi sarcoma.
References
- 1) Mack CL, Adams D, Assis DN, et al. Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology 2020;72:671-722.
- 2) Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D. Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments. World J Gastroenterol 2017;23:6030-48.
- 3) Cetin B, Büyükberber S, Yilmaz IB, et al. Kaposi's sarcoma in patients with ulcerative colitis receiving immunosuppressive drugs: report of a case. Turk J Gastroenterol 2011;22:621-5.
- 4) Kilincalp S, Akıncı H, Hamamci M, Coşkun Y, Yüksel I. Kaposi's sarcoma developing in a HIV-negative Crohn's disease patient shortly after azathioprine and corticosteroid treatment. J Crohns Colitis 2014;8:558-9.
- 5) Saxena A, Netchiporouk E, Al-Rajaibi R, Billick R, Roshdy O. Iatrogenic Kaposi's sarcoma after immunosuppressive treatment for granulomatosis with polyangiitis (Wegener's). JAAD Case Rep 2015;1:71-3.
- 6) Cesarman E, Damania B, Krown SE, et al. Kaposi sarcoma. Nat Rev Dis Primers 2019;5:9.
- 7) Siegel JH, Janis R, Alper JC, et al. Disseminated visceral Kaposi’s sarcoma. Appearance after human renal homograft operation. JAMA 1969;207:1493-6.
- 8) Qunibi W, Al-Furayh O, Almeshari K, et al. Serologic association of human herpesvirus eight with posttransplant Kaposi's sarcoma in Saudi Arabia. Transplantation 1998;65:583-5.
- 9) Schneider JW, Dittmer DP. Diagnosis and Treatment of Kaposi Sarcoma. Am J Clin Dermatol 2017;18:529-39.
- 10) Trattner A, Hodak E, David M, Neeman A, Sandbank M. Kaposi's sarcoma with visceral involvement after intraarticular and epidural injections of corticosteroids. J Am Acad Dermatol 1993;29:890-4
There are 10 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | August 26, 2021 |
| Published in Issue | Year 2021 Volume: 20 Issue: 2 |
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