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Human Microbiome: Nutritional and Health Effects

Year 2017, , 409 - 415, 24.12.2017
https://doi.org/10.24323/akademik-gida.370267

Abstract

The
presence of microorganisms, which we share our bodies, has been known for years.
The human body is a structure that hosts both its own genome and genome
belonging to a group of microbes that live together. However, changes in our
lifestyle and new molecular compounds we encounter cause various effects on
microorganisms. Recent studies also indicate that these groups of
microorganisms have more serious impact on human health than expected. Enlightening
this structure and interaction between them will obviously make important
contributions on microbiome’s impact on human health and even in determining
the treatment of diseases.

References

  • [1] Ley, R.E., 2010. Obesity and the human microbiome. Current Opinion in Gastroenterology 26(1): 5-11.
  • [2] Rajendhran. J., Gunasekaran. P., 2010. Human microbiomics. Indian Journal of Microbiology 50: 109-112.
  • [3] Zarco, M.F., Vess, T.J., Ginsburg. G.S., 2012. The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Diseases 18: 109-120.
  • [4] Taggart, H., Bergstrom, L., 2014. An overview of the microbiome and the effects of antibiotics. Journal of Nurse Practice 10: 445-450.
  • [5] Hattori, M., Taylor, T.D., 2009. The human intestinal microbiome: A new frontier of human biology. DNA Reseaerch 16: 1-12.
  • [6] Backhed, F., 2012. Host responses to the human microbiome. Nutrition Reviews 70: 14-17.
  • [7] Cowie, C.C., Rust, K.F., Ford, E.S., Eberhardt, M.S., Byrdholt, D.D., Li, C., 2009. Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care 32(2): 287–294.
  • [8] D’Adamo, E., Santoro, N., Caprio, S., 2011. Metabolic syndrome in pediatrics: Old concepts revised, new concepts discussed. Pediatr. Clin. North Am. 58(5): 1241–1255.
  • [9] Harris, K., Kassis, A., Major, G., Chou, C.J., 2012. Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? Journal of Obesity 2012: Article ID879151.
  • [10] Karaçay, B., 2010. İçimizdeki dünya: Mikrobiyom. Bilim ve Teknik 515: 36-43.
  • [11] Bozdayı, G., 2014. Klinik mikrobiyolojik örnek alma yöntemleri sunusu. http://slideplayer.biz.tr/ Erişim Tarihi: 12.10.2014
  • [12] Zimmer, C., 2010. How microbes defend and define us. New York Times, Retrieved: 204-206. www.nytimes.com Erişim Tarihi: 10.10.2014
  • [13] Koç, A.N., 2008. İnsan vücudunun normal florası sunusu, Erciyes Üniversitesi Tıp Fakültesi, mikrobiyoloji ve klinik mikrobiyoloji anabilim dalı. tip.erciyes.edu.tr/ders_notu/m_doganay/ Erişim Tarihi: 13.10.2014
  • [14] Rosenwalda,, A.G., Gaurav, S.A., Ramana, M., Jennifer, R.C., Janet, S.R., 2012. The human microbiome project: An opportunity to engage undergraduates in research. Procedia Computer Science 9: 540-549.
  • [15] Cammorata, G., Laniro, G., Bibbo, S., Gasbarriai. A., 2014, Gut microbiota modulation; probiotics, antibiotics or fecal microbiota transplantation? International Journal of Emergency Medicine 9: 365-373.
  • [16] Cho, I., Yamanishi, S., Cox, L., Methé, B.A., Zavadil, J, Li, K., Gao, Z., Mahana, D., Raju, K., Teitler, I., Li, H., Alekseyenko, A.V., Blaser, M.J., 2012. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 488(7413): 621-626.
  • [17] Sommer, M.O.A., Dantas, G., George, M., 2011. Antibiotics and the resistant microbiome. Current Opinion in Microbiology 14(5): 556-563.
  • [18] Goldstein, E.J.C., 2011. Beyond the target pathogen: Ecological effects of the hospital formulary. Current Opinion in Infectious Diseases 24(1): 21-31.
  • [19] Rhee, S.H., Pothoulakis, C., Mayer, E.A., 2009. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nature Reviews Gastroenterology & Hepatology 6(5): 306–314.
  • [20] Camara, R.J., Ziegler, R., Begre, S., Schoepfer, A.M., VonKanel, R., 2009. The role of psychological stress in inflammatory bowel disease: quality assessment of methods of 18 prospective studies and suggestions for future research. Digestion 80(2): 129–139.
  • [21] Bonaz, B., Sabate, J.M., 2009. Brain-gut axis dysfunction. Gastroenterologie Clinique Et Biologique 33(1): 48–58.
  • [22] Collins, S.M., Bercik, P., 2009. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 136(6): 2003–2014.
  • [23] Cryan, J.F., O’Mahony, S.M., 2011. The microbiome-gut-brain axis: from bowel to behaviour. Journal of Neurogastroenterology and Motility 23: 187-192.
  • [24] Wong, J.M., 2014. Gut microbiota and cardiometabolic outcomes: Influence of dietary patterns and their associated components. American Journal of Clinical Nutrition 100: 369-377.
  • [25] Vandenplas, Y., Veereman-Wauters, G., DeGreef, E., Peeters, S., Casteels, A., Mahler, T., Devreker, T., Hauser, B., 2011. Probiotics and prebiotics in prevention and treatment of diseases in infants and children. Journal De Pediatria 87(4): 292-300.
  • [26] Kinross, J.M., Darzi, A.W., Nicholson, J.K., 2011. Gut microbiome-host interactions in health and disease. Genome Medicine 3: 14.
  • [27] Tilg, H., Moschen, A.R., 2015. Food, immunity, and the microbiome. Gastroenterology 148: 1107–1119.
  • [28] Anon, 2015. Ecological associations among microorganisms. Boundless Microbiology, https://www.boundless.com/microbiology/ Erişim Tarihi: 28.01.2015.
  • [29] Cani, P.D., Everard, A., Duparc, T., 2013. Gut microbiota, Enteroendocrine functions and metabolism. Current Opinion in Pharmacology 13: 935–940.
  • [30] Fung, T.C., Olson, C.A., Hsiao, E.Y., 2017. Interactions between the microbiota, immuneand nervous system in health and disease. Nature Neuroscience 20: 145-155.
  • [31] Greiner, T., Backhed, F., 2011. Effects of the gut microbiota on obesity and glucose homeostasis. Trends in Endocrinology & Metabolism 22: 117–123.
  • [32] Leung, J., Burke, B., Ford, D., Garvin, G., Kom, C., Sulis, C., Bhadelia, N., 2013. Possible association between obesity and Clostridium difficile. Emerging Infectious Diseases 19: 1791-1796.
  • [33] Abbott, A., 2014. Sugar substitutes linked to obesity. Nature 513(7518): 290.
  • [34] Gollwitzer, E.S., Saglani, S., Trompette, A., Yadava, K., Sherburn, R., McCoy, K.D., 2014. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nature Medicine 20: 642-647.
  • [35] Tomosada, Y., Chiba, E., Zelaya, H., Takahashi, T., Tsukida, K., Kitazawa, H., 2013. Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection. BioMedical Central Immunology 14: 40.
  • [36] Ahluwalia, S.K., Peng, R.D., Breysse, P.N., Diette, G.B., Curtin-Brosnan, J., Aloe, C., 2013. Mouse allergen is the major allergen of public health relevance in Baltimore City. Journal of Allergy and Clinical Immunology 132: 830-835.
  • [37] Gern, J.E., 2010. The urban environment and childhood asthma study. Journal of Allergy and Clinical Immunology 125: 545-549.
  • [38] Lynch, S.V., Wood, R.A., Boushey, H., Bacharier, L.B., Bloomberg, G.R., Kattan, M., 2014. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. Journal of Allergy and Clinical Immunology 134: 593-601.
  • [39] Stefka, A.T., Feehley, T., Tripathi, P., Qiu, J., McCoy, K., Mazmanian, S.K., 2014. Commensal bacteria protect against food allergen sensitization. Proceedings of the National Academy of Sciences of the United States of America 111(36): 13145-13150.
  • [40] Rubin, T.A, Gessert, C.E., Aas, J., Bakken, J.S., 2013. Fecal microbiome transplantation for recurrent Clostridium difficile infection: report on a case series. Anaerobe 19: 22-26.
  • [41] Russell, G., Kaplan, J., Ferraro, M., Michelow, I.C., 2010. Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol. Pediatrics 126(1): 239-242.
  • [42] Savage, D.C., 1977. Microbial ecology of the gastrointestinal tract. Annual Review of Microbiology 31:107–133.
  • [43] Eckburg, P.B., Bik, E.M., Bernstein, C.N., Purdom, E., Dethlefsen, L., Sargent, M.G., Nelson, K.E., Relman, D.A., 2005. Diversity of the human intestinal microbial flora. Science 308: 635–1638.
  • [44] Biedermann, L., Rogler, G., 2015. The intestinal microbiota: its role in health and disease. European Journal of Pediatrics 174: 151-167.
  • [45] Collado, M.C., Rautava, S., Isolauri, E., Salminen, S., 2015. Gut microbiota: a source of novel tools to reduce the risk of human disease? Pediatric Research 77: 182-188.
  • [46] Tkacz, A., Poole, P., 2015. Role of root microbiota in plant productivity. Journal of Experimental Botany 66: 2167-2175.
  • [47] Yazbek, P.B., Trindade, A.B., Chin, C.M., Santos, J.L., 2015. Challenges to the treatment and new perspectives for the eradication of Helicobacter pylori. Digestive Diseases and Sciences 60: 2901-2912.
  • [48] Duda-Chodak, A., Tarko, T., Satora, P., Sroka, P., 2015. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European Journal of Nutrition 54: 325-341.

İnsan Mikrobiyomu: Beslenme ve Sağlık Üzerindeki Etkileri

Year 2017, , 409 - 415, 24.12.2017
https://doi.org/10.24323/akademik-gida.370267

Abstract

Vücudumuzu paylaştığımız mikroorganizmaların varlığı eskiden beri bilinmektedir.
İnsan vücudu hem kendi genomunu hem de birlikte yaşadığı mikroorganizma topluluğuna
ait genomu barındıran bir yapıdır. Ancak yaşam şeklimizdeki değişiklikler ve
özellikle de vücudumuza aldığımız yeni moleküler bileşikler bu
mikroorganizmalar üzerinde çeşitli etkilere neden olmaktadır. Yapılan son
çalışmalar bize bu mikroorganizma topluluklarının insan sağlığı üzerinde tahmin
edilenden daha fazla etkiye sahip olduğunu göstermektedir. Bu yapının ve kendi
aralarındaki etkileşimin aydınlatılması, mikrobiyomun insan sağlığına olan
etkisinin görülmesinde ve hatta hastalıkların tedavilerinin belirlenmesinde
önemli katkılar sağlayacağı açıktır.

References

  • [1] Ley, R.E., 2010. Obesity and the human microbiome. Current Opinion in Gastroenterology 26(1): 5-11.
  • [2] Rajendhran. J., Gunasekaran. P., 2010. Human microbiomics. Indian Journal of Microbiology 50: 109-112.
  • [3] Zarco, M.F., Vess, T.J., Ginsburg. G.S., 2012. The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Diseases 18: 109-120.
  • [4] Taggart, H., Bergstrom, L., 2014. An overview of the microbiome and the effects of antibiotics. Journal of Nurse Practice 10: 445-450.
  • [5] Hattori, M., Taylor, T.D., 2009. The human intestinal microbiome: A new frontier of human biology. DNA Reseaerch 16: 1-12.
  • [6] Backhed, F., 2012. Host responses to the human microbiome. Nutrition Reviews 70: 14-17.
  • [7] Cowie, C.C., Rust, K.F., Ford, E.S., Eberhardt, M.S., Byrdholt, D.D., Li, C., 2009. Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care 32(2): 287–294.
  • [8] D’Adamo, E., Santoro, N., Caprio, S., 2011. Metabolic syndrome in pediatrics: Old concepts revised, new concepts discussed. Pediatr. Clin. North Am. 58(5): 1241–1255.
  • [9] Harris, K., Kassis, A., Major, G., Chou, C.J., 2012. Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? Journal of Obesity 2012: Article ID879151.
  • [10] Karaçay, B., 2010. İçimizdeki dünya: Mikrobiyom. Bilim ve Teknik 515: 36-43.
  • [11] Bozdayı, G., 2014. Klinik mikrobiyolojik örnek alma yöntemleri sunusu. http://slideplayer.biz.tr/ Erişim Tarihi: 12.10.2014
  • [12] Zimmer, C., 2010. How microbes defend and define us. New York Times, Retrieved: 204-206. www.nytimes.com Erişim Tarihi: 10.10.2014
  • [13] Koç, A.N., 2008. İnsan vücudunun normal florası sunusu, Erciyes Üniversitesi Tıp Fakültesi, mikrobiyoloji ve klinik mikrobiyoloji anabilim dalı. tip.erciyes.edu.tr/ders_notu/m_doganay/ Erişim Tarihi: 13.10.2014
  • [14] Rosenwalda,, A.G., Gaurav, S.A., Ramana, M., Jennifer, R.C., Janet, S.R., 2012. The human microbiome project: An opportunity to engage undergraduates in research. Procedia Computer Science 9: 540-549.
  • [15] Cammorata, G., Laniro, G., Bibbo, S., Gasbarriai. A., 2014, Gut microbiota modulation; probiotics, antibiotics or fecal microbiota transplantation? International Journal of Emergency Medicine 9: 365-373.
  • [16] Cho, I., Yamanishi, S., Cox, L., Methé, B.A., Zavadil, J, Li, K., Gao, Z., Mahana, D., Raju, K., Teitler, I., Li, H., Alekseyenko, A.V., Blaser, M.J., 2012. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 488(7413): 621-626.
  • [17] Sommer, M.O.A., Dantas, G., George, M., 2011. Antibiotics and the resistant microbiome. Current Opinion in Microbiology 14(5): 556-563.
  • [18] Goldstein, E.J.C., 2011. Beyond the target pathogen: Ecological effects of the hospital formulary. Current Opinion in Infectious Diseases 24(1): 21-31.
  • [19] Rhee, S.H., Pothoulakis, C., Mayer, E.A., 2009. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nature Reviews Gastroenterology & Hepatology 6(5): 306–314.
  • [20] Camara, R.J., Ziegler, R., Begre, S., Schoepfer, A.M., VonKanel, R., 2009. The role of psychological stress in inflammatory bowel disease: quality assessment of methods of 18 prospective studies and suggestions for future research. Digestion 80(2): 129–139.
  • [21] Bonaz, B., Sabate, J.M., 2009. Brain-gut axis dysfunction. Gastroenterologie Clinique Et Biologique 33(1): 48–58.
  • [22] Collins, S.M., Bercik, P., 2009. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 136(6): 2003–2014.
  • [23] Cryan, J.F., O’Mahony, S.M., 2011. The microbiome-gut-brain axis: from bowel to behaviour. Journal of Neurogastroenterology and Motility 23: 187-192.
  • [24] Wong, J.M., 2014. Gut microbiota and cardiometabolic outcomes: Influence of dietary patterns and their associated components. American Journal of Clinical Nutrition 100: 369-377.
  • [25] Vandenplas, Y., Veereman-Wauters, G., DeGreef, E., Peeters, S., Casteels, A., Mahler, T., Devreker, T., Hauser, B., 2011. Probiotics and prebiotics in prevention and treatment of diseases in infants and children. Journal De Pediatria 87(4): 292-300.
  • [26] Kinross, J.M., Darzi, A.W., Nicholson, J.K., 2011. Gut microbiome-host interactions in health and disease. Genome Medicine 3: 14.
  • [27] Tilg, H., Moschen, A.R., 2015. Food, immunity, and the microbiome. Gastroenterology 148: 1107–1119.
  • [28] Anon, 2015. Ecological associations among microorganisms. Boundless Microbiology, https://www.boundless.com/microbiology/ Erişim Tarihi: 28.01.2015.
  • [29] Cani, P.D., Everard, A., Duparc, T., 2013. Gut microbiota, Enteroendocrine functions and metabolism. Current Opinion in Pharmacology 13: 935–940.
  • [30] Fung, T.C., Olson, C.A., Hsiao, E.Y., 2017. Interactions between the microbiota, immuneand nervous system in health and disease. Nature Neuroscience 20: 145-155.
  • [31] Greiner, T., Backhed, F., 2011. Effects of the gut microbiota on obesity and glucose homeostasis. Trends in Endocrinology & Metabolism 22: 117–123.
  • [32] Leung, J., Burke, B., Ford, D., Garvin, G., Kom, C., Sulis, C., Bhadelia, N., 2013. Possible association between obesity and Clostridium difficile. Emerging Infectious Diseases 19: 1791-1796.
  • [33] Abbott, A., 2014. Sugar substitutes linked to obesity. Nature 513(7518): 290.
  • [34] Gollwitzer, E.S., Saglani, S., Trompette, A., Yadava, K., Sherburn, R., McCoy, K.D., 2014. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nature Medicine 20: 642-647.
  • [35] Tomosada, Y., Chiba, E., Zelaya, H., Takahashi, T., Tsukida, K., Kitazawa, H., 2013. Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection. BioMedical Central Immunology 14: 40.
  • [36] Ahluwalia, S.K., Peng, R.D., Breysse, P.N., Diette, G.B., Curtin-Brosnan, J., Aloe, C., 2013. Mouse allergen is the major allergen of public health relevance in Baltimore City. Journal of Allergy and Clinical Immunology 132: 830-835.
  • [37] Gern, J.E., 2010. The urban environment and childhood asthma study. Journal of Allergy and Clinical Immunology 125: 545-549.
  • [38] Lynch, S.V., Wood, R.A., Boushey, H., Bacharier, L.B., Bloomberg, G.R., Kattan, M., 2014. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. Journal of Allergy and Clinical Immunology 134: 593-601.
  • [39] Stefka, A.T., Feehley, T., Tripathi, P., Qiu, J., McCoy, K., Mazmanian, S.K., 2014. Commensal bacteria protect against food allergen sensitization. Proceedings of the National Academy of Sciences of the United States of America 111(36): 13145-13150.
  • [40] Rubin, T.A, Gessert, C.E., Aas, J., Bakken, J.S., 2013. Fecal microbiome transplantation for recurrent Clostridium difficile infection: report on a case series. Anaerobe 19: 22-26.
  • [41] Russell, G., Kaplan, J., Ferraro, M., Michelow, I.C., 2010. Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol. Pediatrics 126(1): 239-242.
  • [42] Savage, D.C., 1977. Microbial ecology of the gastrointestinal tract. Annual Review of Microbiology 31:107–133.
  • [43] Eckburg, P.B., Bik, E.M., Bernstein, C.N., Purdom, E., Dethlefsen, L., Sargent, M.G., Nelson, K.E., Relman, D.A., 2005. Diversity of the human intestinal microbial flora. Science 308: 635–1638.
  • [44] Biedermann, L., Rogler, G., 2015. The intestinal microbiota: its role in health and disease. European Journal of Pediatrics 174: 151-167.
  • [45] Collado, M.C., Rautava, S., Isolauri, E., Salminen, S., 2015. Gut microbiota: a source of novel tools to reduce the risk of human disease? Pediatric Research 77: 182-188.
  • [46] Tkacz, A., Poole, P., 2015. Role of root microbiota in plant productivity. Journal of Experimental Botany 66: 2167-2175.
  • [47] Yazbek, P.B., Trindade, A.B., Chin, C.M., Santos, J.L., 2015. Challenges to the treatment and new perspectives for the eradication of Helicobacter pylori. Digestive Diseases and Sciences 60: 2901-2912.
  • [48] Duda-Chodak, A., Tarko, T., Satora, P., Sroka, P., 2015. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European Journal of Nutrition 54: 325-341.
There are 48 citations in total.

Details

Subjects Food Engineering
Journal Section Review Papers
Authors

Sena Çetinbaş This is me 0000-0002-7210-7398

Fulya Kemeriz This is me 0000-0001-6041-2750

Gizem Göker This is me 0000-0001-9244-1337

İlknur Biçer This is me 0000-0002-3214-889X

Yakup Sedat Velioğlu 0000-0002-3281-6229

Publication Date December 24, 2017
Submission Date October 14, 2015
Published in Issue Year 2017

Cite

APA Çetinbaş, S., Kemeriz, F., Göker, G., Biçer, İ., et al. (2017). İnsan Mikrobiyomu: Beslenme ve Sağlık Üzerindeki Etkileri. Akademik Gıda, 15(4), 409-415. https://doi.org/10.24323/akademik-gida.370267
AMA Çetinbaş S, Kemeriz F, Göker G, Biçer İ, Velioğlu YS. İnsan Mikrobiyomu: Beslenme ve Sağlık Üzerindeki Etkileri. Akademik Gıda. December 2017;15(4):409-415. doi:10.24323/akademik-gida.370267
Chicago Çetinbaş, Sena, Fulya Kemeriz, Gizem Göker, İlknur Biçer, and Yakup Sedat Velioğlu. “İnsan Mikrobiyomu: Beslenme Ve Sağlık Üzerindeki Etkileri”. Akademik Gıda 15, no. 4 (December 2017): 409-15. https://doi.org/10.24323/akademik-gida.370267.
EndNote Çetinbaş S, Kemeriz F, Göker G, Biçer İ, Velioğlu YS (December 1, 2017) İnsan Mikrobiyomu: Beslenme ve Sağlık Üzerindeki Etkileri. Akademik Gıda 15 4 409–415.
IEEE S. Çetinbaş, F. Kemeriz, G. Göker, İ. Biçer, and Y. S. Velioğlu, “İnsan Mikrobiyomu: Beslenme ve Sağlık Üzerindeki Etkileri”, Akademik Gıda, vol. 15, no. 4, pp. 409–415, 2017, doi: 10.24323/akademik-gida.370267.
ISNAD Çetinbaş, Sena et al. “İnsan Mikrobiyomu: Beslenme Ve Sağlık Üzerindeki Etkileri”. Akademik Gıda 15/4 (December 2017), 409-415. https://doi.org/10.24323/akademik-gida.370267.
JAMA Çetinbaş S, Kemeriz F, Göker G, Biçer İ, Velioğlu YS. İnsan Mikrobiyomu: Beslenme ve Sağlık Üzerindeki Etkileri. Akademik Gıda. 2017;15:409–415.
MLA Çetinbaş, Sena et al. “İnsan Mikrobiyomu: Beslenme Ve Sağlık Üzerindeki Etkileri”. Akademik Gıda, vol. 15, no. 4, 2017, pp. 409-15, doi:10.24323/akademik-gida.370267.
Vancouver Çetinbaş S, Kemeriz F, Göker G, Biçer İ, Velioğlu YS. İnsan Mikrobiyomu: Beslenme ve Sağlık Üzerindeki Etkileri. Akademik Gıda. 2017;15(4):409-15.

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