Anti-DFS70 Antikor Pozitifliği Saptanan ve Sjögren Sendromu Tanısı Alan İki Kardeş

Year 2019, Volume: 5 Issue: 3, 545 - 547, 01.01.2019

Sevcan Uğur Cahit Kaçar

Abstract

Sjögren sendromu sistemik otoimmün bir hastalıktır ve sicca semptomlarına neden olur. Sjögren sendromlu hastaların Sjögren sendromlu yakınları olabilir. Anti-yoğun ince benekli 70 Anti-DFS70 antikor pozitifliği anti nükleer antikor pozitif ANA sağlıklı bireylerde sık görülür. Biz bu raporda, anti-DFS70 antikoru pozitifliği olmasına rağmen Sjögren sendromu tanısı alan iki kız kardeşi sunmayı amaçladık

Keywords

Sjögren sendromu, Anti-DFS70, ANA

Two Sibling Cases who were Diagnosed with Sjögren Syndrome and were Positive for Anti-DFS70 Antibodies

Abstract

Sjögren syndrome is a systemic autoimmune disease and causes sicca symptoms. Patients with Sjögren syndrome can also have relatives with Sjögren syndrome. Anti-dense fine speckled 70 Anti-DFS70 antibodies are common among ANA-positive healthy individuals. In this article, we report two sisters who were diagnosed with Sjögren syndrome and had anti-DFS70 antibodies

Keywords

Sjögren syndrome, Anti-DFS 70, ANA

References

• Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M. Sjögren syndrome. Nat Rev Dis Primers 2016;2:16047
• Soto-Cárdenas MJ, Gandía M, Brito-Zerón P, Arias MT, Armiger N, Bové A, Bosch X, Retamozos S, Akusbi M, Perez-D-Lis M, Gueitasi H, Kostov B, Perez- Alvarez , Siso- Almirall A, Lozano F, Ramos-Casals M. Etiopathogenic role of surfactant protein d in the clinical and immunological expression of primary Sjögren syndrome. J Rheumatol 2015;42(1):111- 8.
• Lichtenfeld JL, Kirschner RH, Wiernik PH. Familial Sjögren’s syndrome with associated primary salivary gland lymphoma. Am J Med 1976;60(2):286-92.
• Lee H, Kim Y, Han K, Oh EJ. Application of anti-DFS70 antibody and specific autoantibody test algorithms to patients with the dense fine speckled pattern on HEp-2 cells. Scand J Rheumatol 2016;45(2):122-8.
• Lichtenfeld JL, Kirschner RH, Wiernik PH. Familial Sjogren’s syndrome with associated primary salivary gland lymphoma. Am J Med 1976;60:286-92.
• Sabio JM, Milla E, Jimenez-Alonso J. A multicase family with primary Sjogren’s syndrome. J Rheumatol 2001;28:1932-4.
• Boling EP, Wen J, Reveille JD, Bias WB, Chused TM, Arnett FC. Primary Sjogren’s syndrome and autoimmune hemolytic anemia in sisters: A family study. Am J Med 1983;74:1066-71.
• Kuo CF, Grainge MJ, Valdes AM, See LC, Luo SF, Yu KH, Zhang W, Doherty M. Familial risk of Sjögren’s syndrome and co-aggregation of autoimmune diseases in affected families: A nationwide population study. Arthritis Rheumatol 2015;67(7):1904-12.
• Michael Mahler, Pier-Luigi Meroni, Xavier Bossuyt, Marvin J. Fritzler current concepts and future directions for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. J Immunol Res 2014;2014:315179.
• Seelig CA, Bauer O, Seelig HP. Autoantibodies against DFS70/LEDGF exclusion markers for systemic autoimmune rheumatic diseases (SARD). Clin Lab 2016;62(4):499-517.
• Shovman O, Gilburd B, Chayat C, Amital H, Langevitz P, Watad A, Guy A, Perez D, Azoulay D, Blank M, Segal Y, Bentow C, Mahler M, Shoenfeld Y Prevalence of anti- DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases. Clin Exp Rheumatol 2018;36(1):121-6.
• Watanabe A, Kodera M, Sugiura K, Usuda T, Tan EM, Takasaki Y, Tomita Y, Muro Y. Anti-DFS70 antibodies in 597 healthy hospital workers. Arthritis Rheum 2004;50(3):892-900.
• Muro Y, Ogawa Y, Sugiura K, Tomita Y. HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease. J Autoimmun 2006;26(4):252-7.
• Conrad K, Röber N, Andrade LE, Mahler M. The clinical relevance of anti DFS70 autoantibodies. Clin Rev Allergy Immunol 2017;52(2):202-16.