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Dental Outlook in Transplant Patients

Year 2014, Volume: 23 Issue: 2, 197 - 209, 30.10.2014
https://doi.org/10.17827/aktd.93406

Abstract

In today's scenario dentists are more likely to encounter transplant patients for dental care as annually more than 100000 transplantations occur worldwide. Untreated dental disease represents a potential risk for infection and deprived quality of life in transplant patients. These patients are prone for many oral diseases and minor negligence can lead to fatal consequences. This paper aims to provide an insight of transplantation immunology, common oral manifestations and an effective treatment plan depending on the medical condition of the patient. In this review it is found that prophylactic and therapeutic dental treatment is essential at the primary level to prevent serious infections from oral sources during immunosuppression and the elective dental treatment should be preferably planned during the stable post transplantation period.On the basis of the literature review it is recommended that the dental care in these compromised patients has to be modified to meet their medical status and also depending upon the type of transplantation.

References

  • Matesanz R, Mahillo B, Alvarez M, Carmona M. Global observatory and database on donation and transplantation: world overview on transplantation activities. Transplant Proc. 2009; 41:229730
  • Denny B, Kienhuis M. Using crisis theory to explain the quality of life of organ transplant patients. Prog Transplant. 2011; 21:182-9.
  • Sollecito TP, Pinto A, Naji A, Porter D. Transplantation medicine. In Burket’s Oral Medicine, 11th edition. (Eds M Glick, MS Greenberg, JA Ship):461-80. Hamilton, Ontario, BC Decker, 2008.
  • Little JW, Falace AD, Miller CS, Rhodus NL. Dental Management of the Medically Compromised Patient, 7th ed. St Louis, Mosby, 2008.
  • Yamagata K, Onizawa K, Yanagawa T, Hasegawa Y, Kojima H, Nagasawa T et al. A prospective study to evaluate a new dental management protocol before hematopoietic stem cell transplantation. Bone Marrow Transplant. 2006; 38:237-42.
  • Fabuel LC, Esteve CV, Perez MGS. Dental management in transplant patients. J ClinExp Dent. 2011; 3:e43-52.
  • Martinez OM, Rosen HR. Basic concepts in transplant immunology. Liver Transpl. 2005; 11:370
  • Wilhelm MJ, Kusaka M, Pratschke J, Tinley NL. Chronic rejection: increasing evidence for the importance of allogen independent factors. Transplant Proc. 1998; 30:2402-6.
  • Jonuleit H, Schmitt E, Steinbrink K, Enk AH. Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol. 2001; 22:394-400.
  • Lau AH, Thomson AW. Dendritic cells and immune regulation in the liver. Gut. 2003; 52:307-14. Khoori AH, Einollahi B, Ansari G, Moozeh MB. The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients. J Can Dent Assoc. 2003; 69:236
  • Guggenheimer J, Eghtesad B, Stock DJ. Dental management of the (solid) organ transplant patient. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95:383-9.

Transplant Hastalarında Diş Sağlığı

Year 2014, Volume: 23 Issue: 2, 197 - 209, 30.10.2014
https://doi.org/10.17827/aktd.93406

Abstract

Dünya geneline baktığımızda her yıl 100000'den fazla transplantasyon yapılmaktadır. Dolayısıyla bu günün beklentisi, diş hekimlerinin her geçen gün transplant hastalarının diş bakımlarıyla daha fazla karşılaşacakları üzerinedir. Henüz tedavi edilmemiş diş hastalığı, enfeksiyonların ortaya çıkmasında risk faktörüdür ve transplant hastalarının hayat kalitelerinde düşüşe neden olmaktadır. Bu hastalar birçok farklı oral hastalığa yakalanmaya meyilli haldedirler ve küçük bir ihmal bile ölümcül sonuçlara neden olabilmektedir. Bu makalenin amacı; transplantasyon immünolojisine, yaygın oral belirtilere ve hastaların sağlık durumlarına bağlı olarak etkili bir tedavi uygulamaya yönelik yaklaşımları belirlemektir. Bu derlemede, gerekli datalara ulaşabilmek için farklı internet sayfalarının yanı sıra Pub Med ve Medline adreslerine 'Medical Subject Headings' ifadesi girilerek 1984 Ocak ayından 2012 Ocak ayına kadar yayımlanmış elektronik dergilerdeki makaleler tarandı. Profilaktik ve terapötik diş tedavileri, immün sistemin baskılandığı durumlarda oral kaynaklı ciddi enfeksiyonlardan primer korunma için gereklidir ayrıca transplantasyon sonrasında da hastalara özel uygun oral tedavi stratejisi belirlenmelidir. Literatür değerlendirmesine göre böyle durumda olan hastaların oral bakımları, hastaların tıbbi durumlarına ve transplantasyon tipine bağlı olarak belirlenmesi gerektiği önerilmektedir.

References

  • Matesanz R, Mahillo B, Alvarez M, Carmona M. Global observatory and database on donation and transplantation: world overview on transplantation activities. Transplant Proc. 2009; 41:229730
  • Denny B, Kienhuis M. Using crisis theory to explain the quality of life of organ transplant patients. Prog Transplant. 2011; 21:182-9.
  • Sollecito TP, Pinto A, Naji A, Porter D. Transplantation medicine. In Burket’s Oral Medicine, 11th edition. (Eds M Glick, MS Greenberg, JA Ship):461-80. Hamilton, Ontario, BC Decker, 2008.
  • Little JW, Falace AD, Miller CS, Rhodus NL. Dental Management of the Medically Compromised Patient, 7th ed. St Louis, Mosby, 2008.
  • Yamagata K, Onizawa K, Yanagawa T, Hasegawa Y, Kojima H, Nagasawa T et al. A prospective study to evaluate a new dental management protocol before hematopoietic stem cell transplantation. Bone Marrow Transplant. 2006; 38:237-42.
  • Fabuel LC, Esteve CV, Perez MGS. Dental management in transplant patients. J ClinExp Dent. 2011; 3:e43-52.
  • Martinez OM, Rosen HR. Basic concepts in transplant immunology. Liver Transpl. 2005; 11:370
  • Wilhelm MJ, Kusaka M, Pratschke J, Tinley NL. Chronic rejection: increasing evidence for the importance of allogen independent factors. Transplant Proc. 1998; 30:2402-6.
  • Jonuleit H, Schmitt E, Steinbrink K, Enk AH. Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol. 2001; 22:394-400.
  • Lau AH, Thomson AW. Dendritic cells and immune regulation in the liver. Gut. 2003; 52:307-14. Khoori AH, Einollahi B, Ansari G, Moozeh MB. The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients. J Can Dent Assoc. 2003; 69:236
  • Guggenheimer J, Eghtesad B, Stock DJ. Dental management of the (solid) organ transplant patient. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95:383-9.
There are 11 citations in total.

Details

Primary Language Turkish
Journal Section Review
Authors

Kauser Ara Shahin This is me

Laxmikanth Chatra This is me

Prashanth Shenai This is me

Prasanna Kumar Rao This is me

Publication Date October 30, 2014
Published in Issue Year 2014 Volume: 23 Issue: 2

Cite

AMA Shahin KA, Chatra L, Shenai P, Rao PK. Transplant Hastalarında Diş Sağlığı. aktd. June 2014;23(2):197-209. doi:10.17827/aktd.93406