Matriks Metalloproteinaz Enzim Ailesi

Year 2013, Volume: 22 Issue: 2, 209 - 220, 01.06.2013

Özlem Görüroğlu Öztürk

Abstract

Matriks metalloproteinazlar, embriyogenezis, doku yeniden yapılandırılması, yara iyileşmesi ve anjiyogenezis gibi pek çok biyolojik süreçte ve ateroskleroz, artrit ve kanser gibi patolojik durumda önemli rol oynamaktadırlar. Bügüne kadar insanlarda, farklı grup matriks metalloproteinaz enzimlerini kodlayan 24 gen tanımlanmıştır. Bu derlemede, matriks metalloproteinaz ailesinin üyeleri, bunların substrat özgüllüğü, yapıları, fonksiyonları ve enzim aktivitelerinin doku inhibitörleri ile düzenlenmesi tartışılmıştır.

Keywords

Doku inhibitörleri, jelatinaz, kollojenaz, matriks metalloproteinaz

Matrix Metalloproteinase Enzyme Family

Abstract

Matrix metalloproteinases play an important role in many biological processes such as embriogenesis, tissue remodeling, wound healing, and angiogenesis, and in some pathological conditions such as atherosclerosis, arthritis and cancer. Currently, 24 genes have been identified in humans that encode different groups of matrix metalloproteinase enzymes. This review discuss the members of the matrix metalloproteinase family and their substrate specificity, structure, function and the regulation of their enzyme activity by tissue inhibitors.

Keywords

Collogenase, gelatinase, matrix metalloproteinase, tisue inhibitors

References

• Rundhaug JE. Matrix metalloproteinases and angiogenesis. J Cell Mol Med. 2005;9:267-85.
• Maskos K. Crystal structures of MMPs in complex with physiological and pharmacological inhibitors. Biochimie. 2005;87:249–63.
• Nishizuka I, Ichikawa Y, Ishikawaa T, Kamiyama M, Hasegawa S, Momiyama N et al. Matrilysin stimulates DNA synthesis of cultured vascular endothelial cells and induces angiogenesis in vivo. Cancer Lett. 2001;173:175–82.
• Folgueras AR, Pendás AM, Sánchez LM, López-Otín C. Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol 2004;48:411-24.
• Zhou Z, Apte SS, Soininen R, Cao R, Baaklini GY, Rauser RW et al. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A. 2000;97:4052-7.
• Pilcher BK, Dumin JA, Sudbeck BD, Krane SM, Welgus HG, Parks WC. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix. J Cell Biol. 1997;137:1445-57. Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell MJ et al. Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol. 2003;162:1123-33.
• Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 2000;14:2123–33.
• Borkakoti N. Matrix metalloproteases: variations on a theme. Prog Biophys Mol Biol. 1998;70:73
• Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol. 2003;200:448–64.
• Overall CM, López-Otín C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002;2:657-72.
• Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T. Regulation of matrix metalloproteinases: An overview. Mol Cell Biochem. 2003;253:269–85.
• Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol. 2000;18:1135-49.
• Fini ME, Cook JR, Mohan R. Regulation of MMP gene expression, in Parks WC, Mecham RP (eds): Matrix Metalloproteinases. San Diego, CA: Academic Press; 1998. p. 299-356.