Cytogenetic of Male Infertility

Yıl 2011, Cilt: 20 Sayı: 4, 230 - 245, 01.12.2011

Lütfiye Özpak Ayfer Pazarbaşı

Öz

Infertility by definition, is not to get pregnant within one year of regular sexual relationship without protection, affects 15-20% of reproductive age couples. Approximately 30% of infertility cases are male originated. Male infertility is caused by endocrine-related genetic defects affecting urogenital system function. These defects adversely affect subsequent spermatogenesis, sexual function, fertility, early embryonic stage of sexual maturation. Autosomal and gonosomal, numerical and structural chromosome abnormalities and related syndromes rank at the top causes of male infertility. Similar chromosome abnormalities are detected in male infertility and as the rate of these abnormalities increase, it was found to reduce sperm count especially in azospermic and oligozoospermic men.

Anahtar Kelimeler

Infertility, Male Infertility, Spermatogenesis, Sexual Maturation, Regularity of endocrine, Structural and numerical abnormalities.

Erkek İnfertilitesinin Sitogenetiği

Öz

Anahtar Kelimeler

İnfertilite, Erkek infertilitesi, Hormonal düzenleme Spermatogenez, Seksüel olgunlaşma, Sayısal ve yapısal kromozom anormallikleri

Kaynakça

• Mark HFL, Sigman M. Cytogenetics of Male Infertility. In: Medical Cytogenetics, 1st. Edition, New York: Marcel Dekker, 2000; 247-273
• Erişim:(http://www.burclab.com/tr/genetik/teknik-bultenler/Y-kromozom-mikrodelesyonlar) Erişim Tarihi: 15.02.2011 3. Demirhan O, Pazarbaşı A, et. al. : The Clinical Effects Of Isochromosome Xq İn Klinefelter Syndrome: Report Of A Case And Rewiew Of Literature , Genetic Counseling, 2009;3: 235- 242 4. Başaran N. Tıbbi genetik, 6. Baskı, Bilim Teknik Yayınevi, Eskişehir,1996.