A Frequent Childhood Tumor in Mediterranean Basin: Nasopharyngeal Carcinoma

Yıl 2015, Cilt: 24 Sayı: 2, 260 - 270, 05.03.2015

Serhan Küpeli

https://doi.org/10.17827/aktd.43279

Öz

Nasopharyngeal carcinoma is a rare malignancy of childhood having different epidemiological, histopathological and clinical characteristics. The most frequent histopathological type is undifferentiated nasopharyngeal carcinoma and is associated with advanced locoregional disease and distant metastasis in childhood. Because of high incidence of systemic disease in childhood, chemotherapy is the first choice in treatment of advanced disease. Although 5 year’s survival rates have reached 70% with combined therapy modalities, late complications continue to be major problem. Parallel to improvement in the diagnostic skills and therapy, there is an increase in survivors of childhood cancer. Since late effects of cancer therapy can be encountered more often, closer follow-up of nasopharyngeal carcinoma patients who are under serious treatment schemes is an obligation.

Anahtar Kelimeler

Childhood nasopharyngeal carcinoma, therapy modalities, complications

Akdeniz Havzasında Sık Görülen Çocukluk Çağı Tümörü: Nazofarinks Karsinomu

Öz

Nazofarinks karsinomu çocuklarda nadir görülen, farklı epidemiyolojik, histopatolojik ve klinik özellikleri olan bir hastalıktır. Çocuklarda görülen histopatolojik tip hemen her zaman indiferansiye nazofarinks karsinomu olmakta ve ileri lokal-bölgesel yayılımla ve uzak metastazla birliktelik görülmektedir. Çocuklarda görülen sistemik hastalık sıklığının yüksek oluş nedeniyle günümüzde kemoterapi ileri evre hastalıkta ilk seçenek olarak tercih edilmektedir. Kombine tedavi şemalarıyla 5 yıllık sağkalım % 70'Iere ulaşmış olmasına rağmen geç dönem komplikasyonlar önemli sorun olmaya devam etmektedir. Tanı ve tedavideki gelişmelere paralel olarak, çocukluk çağında kanser tedavisi gören ve hayatta kalan birey sayısında önemli bir artış olduğundan ve kanser tedavisinin özellikle geç dönemde görülebilecek yan etkileriyle daha sık karşılaşılabileceğinden ağır tedavi protokolleri uygulanan nazofarinks karsinomu hastalarının bu açıdan yakın takip edilmeleri bir zorunluluktur.

Anahtar Kelimeler

Çocuklarda nazofarinks karsinornu, tedavi şekilleri, komplikasyonlar

Kaynakça

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