Role of NF-Kappa B in the Approach to Pancreatic Ductal Adenocarcinoma

Year 2015, Volume: 24 Issue: 4, 565 - 577, 15.09.2015

Deniz Tuncel

https://doi.org/10.17827/aktd.31545

Abstract

Pancreatic ductal adenocarcinoma is now one of the most common causes of cancer death worldwide. K-ras mutations are present in up to 90% of pancreatic cancer cases. The expression of mutant K-ras activates the Akt/protein kinase B pathway, resulting in the activation of the nuclear factor-kappaB (NF-kB) transcriptional factor. Based on in vitro studies, constitutive NF-kB activity plays a key role in pancreatic carcinoma. NF-kB expression does not have direct effects on the overall survival of pancreatic ductal adenocarcinoma. The correlation with the positive lymph node status suggests a role in invasive properties of the tumor. Activation of NF-kB is most likely an early event in pancreatic carcinogenesis. Due to the increased activation in pancreatic cancer, NF-kB seems to be a good target for therapeutic interventions.

Keywords

Nuclear factor-kappaB, pancreas, adenocarcinoma

Pankreas Duktal Adenokarsinomuna Yaklaşımda NF-Kappa B’nin Rolü

Abstract

Pankreasın duktal adenokarsinomu en agresif kanser tiplerinden biridir. K-ras mutasyonu, %90’a varan oranda pankreas kanseri olgularında mevcuttur. Mutant K-ras ekspresyonu Akt/protein kinaz B yolağını aktive ederek Nükleer Faktör-Kappa B (NF-kB) transkripsiyon faktörü etkin kılar. In vitro çalışmalar ışığında, NF-kB aktivitesinin pankreas karsinomunda anahtar role sahip olduğu bildirilmektedir. Lenf bezi durumu ile NF-kB aktivitesinin korelasyonu tümörün invaziv olma özelliğini ön plana çıkartmakta olup pankreas karsinogenezinde erken aşamalarda görülmesi tedavi açılımlarının geliştirilmesi açısından hedef molekül olabileceğini düşündürmektedir.

Keywords

Nükleer faktör-Kappa B, pankreas, adenokarsinom

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