Overlerde Anjiyogenezi Etkileyen Faktörler

Year 2017, Volume: 26 Issue: 3, 330 - 341, 30.09.2017

Latife Seyran Çelik Ufuk Özgü Mete

https://doi.org/10.17827/aktd.303589

Abstract

Daha önce oluşan kan damarlarından filizlenme yoluyla yeni kan damarlarının oluşum süreci olan anjiyogenez, vücudumuzda hem fizyolojik hem de patolojik birçok durumda görülmektedir. Overlerde anjiyogenez, ovaryan siklusun foliküler ve luteal fazları sırasında normal ovaryan fizyolojik aktivasyonda ve çeşitli ovaryan hastalıklar ile neoplazilerde önemli rol oynamaktadır. Overlerde normal fonksiyon, anjiyogenezi etkileyen birçok proanjiyogenik ve antianjiyogenik faktörler aracılığıyla gerçekleşir. Bu faktörlerin en önemlileri vasküler endotelyal büyüme faktörü, fibroblast büyüme faktörü, anjiyotensin II ve matriks metalloproteinazlar olmakla birlikte, diğer birçok faktör de bu süreçte yer almaktadır. Günümüzde bu konuda artan bilgi birikimi birçok hastalığın patogenezinin anlaşılmasına ve tedavisinde yeni terapötik yaklaşımların ortaya çıkmasına olanak sağlayacaktır.

Keywords

anjiyogenezis, anjiyogenez inhibitörleri, over

Factors Affecting Angiogenesis in Ovaries

Abstract

Angiogenesis is the process of new capillary formation from preexisting vessels that occurs in both the physiological and pathological processes in our body. Ovarian angiogenesis participates in normal ovarian physiologic activation, various ovarian diseases and neoplasms throughout the follicular and luteal phases of the ovarian cycle. The normal ovarian function modulated by a wide range of proangiogenic and antiangiogenic factors that directly affects angiogenesis. The most important of these factors are vascular endothelial growth factor, epidermal growth factor, fibroblast growth factor, angiotensin ıı, matrix metalloproteinases as well as many other factors are involved in this process. Today increased knowledge in this issues will enable the emergence of new therapeutic approaches in the understanding and treatment of pathogenesis of many diseases.

Keywords

angiogenesis, angiogenesis inhibitors, ovary

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