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Effect of Kruppel-like Transcription Factor KLF1 on HbA2 and HbF Values

Year 2017, Volume: 26 Issue: 3, 342 - 351, 30.09.2017
https://doi.org/10.17827/aktd.303591

Abstract

Krüppel-like factors are a family of transcription factors capable of binding GC-rich sequences, have emerged as critical regulators of functions  that play important roles in many fundamental biologic processes, including development, proliferation, differentiation and apoptosis. KLF1 (EKLF) was the first KLF member to be discovered. It is an erythroid-specific transcription factor that is essential for erythropoiesis. In this review, we first give information about the structure, functions and variants of KLF1. The effects of KLF1 on fetal hemoglobin (HbF) and hemoglobin A2 (HbA2) values will be discussed.

References

  • 1- Cao Z, Sun X, Icli B, Wara AK, Feinberg MW. Role of Kruppel-like factors in leukocyte development, function, and disease. Blood. 2010; 116(22):4404-14.
  • 2- Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S. Kruppel-like transcription factors: a functional family. Int J Biochem Cell Biol. 2008;40(10): 1996-2001
  • 3- Suzuki T, Aizawa K, Matsumura T, Nagai R. Vascular implications of the Kruppel-like family of transcription factors. Arterioscler Thromb Vasc Biol. 2005;25(6):1135-1141.
  • 4- Kaczynski J, Cook T, Urrutia R. Sp1- and Kruppellike transcription factors. Genome Biol. 2003;4(2): 206.
  • 5- Chen C, Benjamin MS, Sun X, Otto KB, Guo P, Dong XY. KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line. Int J Cancer, 2006;118 (6), 1346-1355.
  • 6- Bateman NW, Tan D, Pestell RG, Black JD, Black AR. Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem,2004; 279 (13), 12093-12101.
  • 7- Van Vliet J, Turner J, Crossley M. Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. Nucleic Acids Res.2000; 28: 1955–1962.
  • 8- McConnell BB, Yang VW. Mammalian Krüppel-like factors in health and diseases. Physiol Rev. 2010; 90(4):1337-81.
  • 9- Miller IJ, Bieker JJ. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol1993;13(5):2776-2786.
  • 10- Grech L, Borg J. Control of globin gene expression by Kruppel-like Factors. Journal of The Malta Chamber of Scientists.2014; 2(1): 66-77.
  • 11- Perseu L, Satta S, Moi P, Demartis FR, Manunza L, Sollaino MC, Barella S, Cao A, Galanello R. KLF1 gene mutations cause borderline HbA2.2011; 118(16):4454-4458
  • 12- Perkins AC, Sharpe AH, Orkin SH. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995; 375(6529):318-322.
  • 13- Tallack MR, Whitington T, Yuen WS, et al. A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res 2010; 20:1052–1063.
  • 14- Kaczynski J, Cook T, Urrutia R. Sp1- and Kruppellike transcription factors. Genome Biol. 2003;4(2):206.
  • 15- Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S. Kruppel-like transcription factors: A functional family. Int J Biochem Cell Biol., 2008; 40:1996-2001.
  • 16- http://www.geneticapediatrica.it/archivi/2011/archivio4/page.php?id=2
  • 17- https://www.omim.org/KLF1/600599
  • 18- Perkins A, Xu X, Higgs DR, Patrinos GP, Arnaud L, Bieker JJ, Philipsen S. Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants. Blood; 2016; 127(15):1856-62.
  • 19- Magor GW, Tallack MR, Gillinder KR, et al. KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome. Blood. 2015; 125(15):2405-2417.
  • 20- Raiola L, Lussier-Price M, Gagnon D, et al. Structural characterization of a noncovalent complex between ubiquitin and the transactivation domain of the erythroid-specific factor EKLF. Structure. 2013;21(11):2014-2024.
  • 21- Gallienne AE, Dréau HMP, Schuh A, Old JM, Henderson S. Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults. Haematologica, 2012; 97(3): 340–343.
  • 22- Singleton B., Burton N., Green C., Brady R., Anstee D. Mutations in EKLF/KLF1 form the molec-ular basis of the rare blood group in(lu) phenotype. Blood, 2008; 112(5), 2081-2088.

Kruppel Benzeri Transkripsiyon Faktör KLF1’in HbA2 ve HbF Değerlerine Etkisi

Year 2017, Volume: 26 Issue: 3, 342 - 351, 30.09.2017
https://doi.org/10.17827/aktd.303591

Abstract

Krüppel benzeri faktörler, GC bakımından zengin sekansları bağlayabilen transkripsiyon faktörleri ailesidir ve gelişme, çoğalma, farklılaşma ve apoptoz gibi birçok temel biyolojik süreçte önemli rol oynayan fonksiyonların kritik düzenleyicileri olarak ortaya çıkmıştır.  KLF1 (EKLF) keşfedilen ilk KLF üyesiydi. Eritropoez için gerekli olan eritroide özel bir transkripsiyon faktörüdür. Bu derlemede, öncelikle KLF1’ in yapısı, görevleri ve varyantları hakkında bilgi aktarılıp KLF1’in Fetal hemoglobin (HbF) ve Hemoglobin A2 (HbA2) değerleri üzerine etkileri tartışılacaktır.

References

  • 1- Cao Z, Sun X, Icli B, Wara AK, Feinberg MW. Role of Kruppel-like factors in leukocyte development, function, and disease. Blood. 2010; 116(22):4404-14.
  • 2- Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S. Kruppel-like transcription factors: a functional family. Int J Biochem Cell Biol. 2008;40(10): 1996-2001
  • 3- Suzuki T, Aizawa K, Matsumura T, Nagai R. Vascular implications of the Kruppel-like family of transcription factors. Arterioscler Thromb Vasc Biol. 2005;25(6):1135-1141.
  • 4- Kaczynski J, Cook T, Urrutia R. Sp1- and Kruppellike transcription factors. Genome Biol. 2003;4(2): 206.
  • 5- Chen C, Benjamin MS, Sun X, Otto KB, Guo P, Dong XY. KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line. Int J Cancer, 2006;118 (6), 1346-1355.
  • 6- Bateman NW, Tan D, Pestell RG, Black JD, Black AR. Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem,2004; 279 (13), 12093-12101.
  • 7- Van Vliet J, Turner J, Crossley M. Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. Nucleic Acids Res.2000; 28: 1955–1962.
  • 8- McConnell BB, Yang VW. Mammalian Krüppel-like factors in health and diseases. Physiol Rev. 2010; 90(4):1337-81.
  • 9- Miller IJ, Bieker JJ. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol1993;13(5):2776-2786.
  • 10- Grech L, Borg J. Control of globin gene expression by Kruppel-like Factors. Journal of The Malta Chamber of Scientists.2014; 2(1): 66-77.
  • 11- Perseu L, Satta S, Moi P, Demartis FR, Manunza L, Sollaino MC, Barella S, Cao A, Galanello R. KLF1 gene mutations cause borderline HbA2.2011; 118(16):4454-4458
  • 12- Perkins AC, Sharpe AH, Orkin SH. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995; 375(6529):318-322.
  • 13- Tallack MR, Whitington T, Yuen WS, et al. A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res 2010; 20:1052–1063.
  • 14- Kaczynski J, Cook T, Urrutia R. Sp1- and Kruppellike transcription factors. Genome Biol. 2003;4(2):206.
  • 15- Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S. Kruppel-like transcription factors: A functional family. Int J Biochem Cell Biol., 2008; 40:1996-2001.
  • 16- http://www.geneticapediatrica.it/archivi/2011/archivio4/page.php?id=2
  • 17- https://www.omim.org/KLF1/600599
  • 18- Perkins A, Xu X, Higgs DR, Patrinos GP, Arnaud L, Bieker JJ, Philipsen S. Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants. Blood; 2016; 127(15):1856-62.
  • 19- Magor GW, Tallack MR, Gillinder KR, et al. KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome. Blood. 2015; 125(15):2405-2417.
  • 20- Raiola L, Lussier-Price M, Gagnon D, et al. Structural characterization of a noncovalent complex between ubiquitin and the transactivation domain of the erythroid-specific factor EKLF. Structure. 2013;21(11):2014-2024.
  • 21- Gallienne AE, Dréau HMP, Schuh A, Old JM, Henderson S. Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults. Haematologica, 2012; 97(3): 340–343.
  • 22- Singleton B., Burton N., Green C., Brady R., Anstee D. Mutations in EKLF/KLF1 form the molec-ular basis of the rare blood group in(lu) phenotype. Blood, 2008; 112(5), 2081-2088.
There are 22 citations in total.

Details

Subjects Health Care Administration
Journal Section Review
Authors

Gülüzar Özbolat

Abdullah Tuli This is me

Publication Date September 30, 2017
Acceptance Date April 17, 2017
Published in Issue Year 2017 Volume: 26 Issue: 3

Cite

AMA Özbolat G, Tuli A. Kruppel Benzeri Transkripsiyon Faktör KLF1’in HbA2 ve HbF Değerlerine Etkisi. aktd. September 2017;26(3):342-351. doi:10.17827/aktd.303591