Lokal ve Sistemik Renin Anjiyotensin Sistemi

Yıl 2019, Cilt: 28 Sayı: 4, 259 - 269, 31.12.2019

Zehra Çiçek , Kübra Akıllıoğlu Ayşe Dogan

Öz

Renin
Anjiyotensin Sisteminin (RAS) atheroskleroz ve hipertansiyon gibi
kardiyovasküler hastalıkların fizyopatolojisinde önemli rol oynadığı
bildirilmektedir. Vasküler düz kas ve endotel hücresinin RAS, lipoproteinler ve
insülinle etkileşimi, diyabet, miyokart enfarktüs, hipertansiyon, inme ve stent
restenozu gibi hastalıkların gelişimine ve ilerlemesine neden olarak
gösterilmektedir. Sistemik RAS daha çok kan basıncının düzenlenmesini, tuz ve
su alımını, antidiüretik hormon (ADH) salınımını sağlarken, lokal RAS vasküler düz kas
hücrelerinin çoğalması, büyümesi, apopitoz ve inflamasyonunda görev almaktadır.
Çalışmalarda, RAS bileşenlerinin vasküler düz kas, kalp hücresi, yağ dokusu ve
beyin gibi birçok yerde lokal olarak sentezlendiği gösterilmiştir. Vasküler
yapı üzerine hem sistemik hem de lokal olarak sentez edilip etki gösteren
RAS’ın patolojik süreçlerdeki intrasellüler etki mekanizmaları tam olarak
aydınlatılamamıştır. Bu yüzden lokal RAS’ın bileşenlerinin tam anlamıyla
aydınlatılması yeni tedavi yöntemlerinin geliştirilmesinde önemli rol
oynayacaktır.

Anahtar Kelimeler

Düz Kas, Hipertansiyon, Renin Anjiyotensin Sistem

Kaynakça

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