Beşikten Mezara Yaşam Boyu Devam Eden Mikrobiyota

Year 2023, Volume: 32 Issue: 1, 10 - 15, 31.03.2023

Yusuf Döğüş Amin Deami Sertap Döğüş Zafer Yönden

https://doi.org/10.17827/aktd.1257562

Cited By: 1

Abstract

Vücudun bazı bölgesindeki mikrobiyal bileşim, insan kronolojik yaşını nispeten doğru bir şekilde tahmin edebilir. Belirli mikroorganizmaların belirli yaşlarda neden daha bol olduğu büyük ölçüde bilinmemekle birlikte, insan mikrobiyota araştırmaları, doğum ve ölüm arasında meydana gelen bir dizi mikrobiyal topluluk dönüşümünü aydınlatmıştır. Bireyin mikrobiyotanın aktivitesi ve bileşimi, konağın genetik geçmişi, yaşı, diyeti ve sağlık durumundan etkilendiği bilinmektedir. Formülle beslenen bebeklere kıyasla anne sütü ile beslenen bebekler, gençlere kıyasla yaşlılar ve asırlık insanlar, zayıf bireylere kıyasla obezler, sağlıklı veya inflamatuar barsak hastalıklarından (IBH) muzdarip insanlar arasındaki mikrobiyota bileşimi ve aktivitesindeki farklılıklar gösterilmiştir. Bu derlemede, doğumdaki birincil ardışıklıktan, hastalık veya antibiyotik kullanımına bağlı kesintilere ve ölümde mikrobiyal genişlemeye kadar olan aşamaları göstermektedir. Bu çalışmayla, insan bağırsak mikrobiyotasının işlevselliğine ilişkin mevcut anlayışımızı beşikten mezara kadar incelemekteyiz.

Keywords

Bağırsak Mikrobiyotası, Beslenme, Yaşam Evreleri

Supporting Institution

yok

References

• 1. O'Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Rep. 2006;7:688-93.
• 2. Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R et al. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci USA. 2011;108:4578-85.
• 3. Scholtens PA, Oozeer R, Martin R, Amor KB, Knol J. The early settlers: intestinal microbiology in early life. Annu Rev Food Sci Technol. 2012;3:425-47.
• 4. Rajilić-Stojanović M, Heilig HG, Molenaar D, Kajander K, Surakka A, Smidt H et al. Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environ Microbiol. 2009;11:1736-51.
• 5. Zoetendal EG, Rajilic-Stojanovic M, de Vos WM. High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut. 2008;57:1605-15.
• 6. Jalanka-Tuovinen J, Salonen A, Nikkilä J, Immonen O, Kekkonen R, Lahti L et al. Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One. 2011;6:e23035.
• 7. Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010;5:e10667.
• 8. Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut microbiota in health and disease. Physiol Rev. 2010;90:859-904.
• 9. Schwartz S, Friedberg I, Ivanov IV, Davidson LA, Goldsby JS, Dahl DB et al. A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response. Genome Biol. 2012;13:R32.
• 10. Niers L, Martín R, Rijkers G, Sengers F, Timmerman H, van Uden N et al. The effects of selected probiotic strains on the development of eczema (the PandA study). Allergy. 2009;64:1349-58.
• 11. Sjögren YM, Jenmalm MC, Böttcher MF, Björkstén B, Sverremark-Ekström E. Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clin Exp Allergy. 2009;39:518-26.
• 12. Biasucci G, Benenati B, Morelli L, Bessi E, Boehm G. Cesarean delivery may affect the early biodiversity of intestinal bacteria. J Nutr. 2008;138:1796-1800
• 13. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010;107:11971-5.
• 14. Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006;118:511-21.
• 15. Nanthakumar NN, Fusunyan RD, Sanderson I, Walker WA. Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis. Proc Natl Acad Sci U S A. 2000;97:6043-8.
• 16. Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M et al. Human gut microbiome viewed across age and geography. Nature. 2012;486:222-7.
• 17. Favier CF, de Vos WM, Akkermans AD. Development of bacterial and bifidobacterial communities in feces of newborn babies. Anaerobe. 2003;9:219-29.
• 18. Vaishampayan PA, Kuehl JV, Froula JL, Morgan JL, Ochman H, Francino MP. Comparative metagenomics and population dynamics of the gut microbiota in mother and infant. Genome Biol Evol. 2010;2:53-66.
• 19. Marcobal A, Barboza M, Sonnenburg ED, Pudlo N, Martens EC, Desai P et al. Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways. Cell Host Microbe. 2011;10:507-14.
• 20. Turroni F, Peano C, Pass DA, Foroni E, Severgnini M, Claesson MJ et al. Diversity of bifidobacteria within the infant gut microbiota. PLoS One. 2012;7:e36957.
• 21. Sela DA, Chapman J, Adeuya A, Kim JH, Chen F, Whitehead TR et al. The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. Proc Natl Acad Sci U S A. 2008;105:18964-9.
• 22. Boesten R, Schuren F, Ben Amor K, Haarman M, Knol J, de Vos WM. Bifidobacterium population analysis in the infant gut by direct mapping of genomic hybridization patterns: potential for monitoring temporal development and effects of dietary regimens. Microb Biotechnol. 2011;4:417-27.
• 23. González R, Klaassens ES, Malinen E, de Vos WM, Vaughan EE. Differential transcriptional response of Bifidobacterium longum to human milk, formula milk, and galactooligosaccharide. Appl Environ Microbiol. 2008;74:4686-94.
• 24. O'Connell Motherway M, Zomer A, Leahy SC, Reunanen J, Bottacini F, Claesson MJ et al. Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor. Proc Natl Acad Sci USA. 2011;108:11217-22.
• 25. Klaassens ES, Ben-Amor K, Vriesema A, Vaughan EE, de Vos W. The fecal bifidobacterial transcriptome of adults: a microarray approach. Gut Microbes. 2011;2:217-26.
• 26. Knol J, Scholtens P, Kafka C, Steenbakkers J, Gro S, Helm K et al. Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants. J Pediatr Gastroenterol Nutr. 2005 Jan;40(1):36-42.
• 27. Mariat D, Firmesse O, Levenez F, Guimarăes V, Sokol H, Doré J et al. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol. 2009;9:123.
• 28. Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010;5:e10667.
• 29. Macfarlane GT, Macfarlane S. Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebiotics. J Clin Gastroenterol. 2011;45:120-7.
• 30. Claesson MJ, Cusack S, O'Sullivan O, Greene-Diniz R, de Weerd H, Flannery E et al. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A. 2011;108:4586-91.