Sitagliptin: New Oral Antidiabetic Agent for Tip 2 Diabetes Mellitus

Year 2011, Volume: 11 Issue: 2, 1 - 13, 01.08.2011

Ömer Hazman

Abstract

Keywords

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Sitagliptin: Tip 2 Diyabet Tedavisi için Yeni Oral Antidiyabetik Ajan

Abstract

Tip 2 Diyabet (T2DM) dünya genelinde yaygın ve hastalar hatta toplum için önemli sonuçları olan bir epidemik bir hastalıktır. T2DM için mevcut tedavi yöntemlerinin doza bağlı sınırlamaları ve yan etkileri (kilo artışı, hipoglisemi ve sindirim sistemi problemleri gibi) olduğu için, yeni tedavi seçeneklerine ihtiyaç duyulmaktadır. Bu yüzden sitagliptin gibi dipeptidil peptidaz-4 (DPP 4) inhibitörleri olarak adlandırılan yeni bir yaklaşım geliştirilmiştir. Sitagliptinle DPP 4 inhibisyonu, glukagon-like peptid-1 (GLP-1)’in aktivasyonunu engelleyerek insülin sekresyonunu artırır, glukagon sekresyonunu azaltır ve böylelikle kan glukoz seviyeleri dengelenir. Yapılan birçok çalışma göstermektedir ki sitagliptin hastaların kilo almalarını önleyerek ve hipoglisemi riskini azaltarak, güvenilir, tolare edilebilir bir ilaç profili çizmektedir. Bununla birlikte in vitro çalışmalarda sitagliptinin pankreatik beta hücre kütlesini artırdığı ve beta hücre fonksiyonlarını koruduğu gösterilmiştir. Tip 2 diyabet tedavisinde sitagliptin tek başına veya diğer oral antidiyabetiklerle combine tedavi şeklinde kullanılabilir. Bu makalede, yapılan en son araştırmalar incelenerek sitagliptinin T2DM hastalarında glisemik kontrolü sağlamadaki etkinliği ve diyabetik komplikasyonlara etkisi tartışılacaktır.

Keywords

Sitagliptin, DPP 4 inhitörleri, tip 2 diyabet, diyabetik komplikasyonlar.

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