ALKÜ Fen Bilimleri Dergisi 2667-7814 Alanya Alaaddin Keykubat University 10.46740/alku.1511772 Polymer Science and Technologies Polimer Bilimi ve Teknolojileri Mukoadhezyonun Temel Prensipleri Üzerine Bir Derleme: Mukoadhezif Biyopolimer Olarak Kitosan'ın Önemi A Review on Basic Principles of Mucoadhesion: The Importance of Chitosan as a Mucoadhesive Biopolymer https://orcid.org/0000-0002-6340-5107 Eker Fidan Emine Büşra İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA https://orcid.org/0000-0002-9127-2380 Bal Kevser İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA https://orcid.org/0000-0002-1793-0859 Pabuccuoğlu Saadet Kevser İstanbul Üniveersitesi - Cerrahpaşa 01 02 2025 6 3 174 194 07 06 2024 08 08 2024 Copyright © 2019, ALKÜ Fen Bilimleri Dergisi 2019 ALKÜ Fen Bilimleri Dergisi

Mukoadhezif polimerler, vücuttaki göz, burun, vajinal ve bukkal boşluklar ile gastrointestinal sistem gibi mukusla kaplı bölgelerde mukus/epitel yüzeyine yapışma özelliğine sahiptir. Bu nedenle, dozaj formunun mukozadaki kalış süresini arttırma ve ilaç uygulamasını önemli ölçüde iyileştirme özellikleri gösterirler. Kitosan ve modifiye edilmiş türevlerini içeren mukoadhezif ilaç taşıma sistemleri, hem lokal hem de sistemik ilaç taşıma için birçok avantaja sahiptir. Bu derlemenin amacı, fonksiyonel bir mukoadhezif ilaç taşıma sistemi olarak kitosan'ın önemini ortaya koymaktır.

Mucoadhesive polymers have the special functions which lead to adhesion to the mucin/ epithelial surface on the mucus-covered areas in the body such as eye, nose, vaginal and buccal cavities, and GI tract. Therefore, they provide to increase the residence time of the dosage form on the mucosa and to significantly improve the drug administration. Mucoadhesive drug delivery systems containing chitosan and its modified derivatives have many advantages for both local and systemic drug delivery. The goal of this review is to put forward the importance of chitosan as a functionalized mucoadhesive drug delivery system.

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