The Effect of Bolus Vitamin D Supplementation

Year 2019, Volume: 19 Issue: 2, 288 - 297, 28.06.2019

Sinem Bozkurt , Berat Meryem Alkan Fatma Gülçin Ural Hatice Aksekili Fatma Fidan Nebahat Sezer Lale Aktekin Özge Ardıçoğlu Selami Akkuş

https://doi.org/10.17098/amj.582000

Abstract

Objectives: Vitamin D plays an important role in
musculoskeletal and nervous system health. Although, the prevalence of vitamin
D deficiency is fairly high and it may lead to bone abnormalities and muscle
weakness, it is a preventable condition. The aim of this prospective study was
to assess the effects of vitamin D supplementation on balance, mobility, grip
strength, fatigue, depression and quality of life.

Materials and Methods: Between October 1, 2015 and December 31, 2015, a
total of 92 patients with vitamin D insufficiency/deficiency were included in
the study. Demographic characteristics of age, gender, height, weight, serum
25-hydroxyvitamin [25-(OH)D], parathyroid hormone, alkaline phosphatase (ALP),
calcium, and phosphorus levels were recorded. The primary outcome was assessed
the [25-(OH) D] levels at 1 month and 3 month post-treatment. The secondary
outcomes were the efficacy of vitamin D administration on fatigue, mobility,
balance, depression, quality of life (QoL), muscle strength using The
Multidimensional Assessment of Fatigue Scale (MAF), Timed Up and Go Test (TUG),
Single leg stance test (SLS), Beck Depression Inventory (BDI), The Nottingham
Health Profile(NHP), hand dynamometer, respectively at all visits. 

Results: After the 1 month, the vitamin D supplementation had
significantly improved muscle strength, balance ability, mobility, QoL,
depression, and fatigue symptoms. The levels of [25-(OH) D] significant
decreased after 3 months.

Conclusion: Supplemental vitamin D consistently demonstrated beneficial
effects on muscle strength, mobility, balance control, depression, fatigue and
QoL. The 300,000 bolus of vitamin D was well-tolerated and safe in adult
population. We would recommend evaluating vitamin D status once in three
months. 

Keywords

Balance, Fatigue, Muscle strength, Quality of life, Vitamin D

Bolus D Vitamini Takviyesinin Etkileri

Abstract

Amaç: D vitamini, kas-iskelet sistemi ve
sinir sistemi sağlığında önemli bir rol oynar. D vitamini eksikliği prevalansı
oldukça yüksek olup kemik anormallikleri ve kas güçsüzlüğü ile
sonuçlanabilmesine rağmen, önlenebilir bir durumdur. Bu prospektif çalışmanın
amacı, D vitamini desteğinin denge, mobilite, kavrama gücü, yorgunluk,
depresyon ve yaşam kalitesi üzerine etkilerini değerlendirmektir. 

Materyal ve Metot: Çalışmaya 1 Ekim
2015 - 31 Aralık 2015 tarihleri arasında D vitamini yetersizliği / eksiksizliği
olan 92 hasta alındı. Yaş, cinsiyet, boy, kilo, serum 25-hidroksivitamin D [25-
(OH) D], paratiroid hormon, alkalen fosfataz (ALP), kalsiyum ve fosfor
seviyeleri kaydedildi. Primer sonuç, tedavi sonrası 1 ay ve 3 ay sonra [25-
(OH) D] seviyelerini değerlendirmekti. İkincil sonuçlar; tüm vizitlerde D vitamini
uygulamasının yorgunluk, mobilite, denge, depresyon, yaşam kalitesi üzerine
etkinliğinin, sırasıyla Yorgunluk Ölçeğinin Çok Boyutlu Değerlendirilmesi,
Zamanlı Kalk ve Yürü Testi, Tek Bacak Üzerinde Durma Testi, Beck Depresyon
Envanteri, Nottingham Sağlık Profili, el dinamometresi, kullanılarak
değerlendirilmesidir.

Bulgular: 1 ay sonra, D vitamini takviyesi kas
gücünü, denge yeteneğini, mobiliteyi, yaşam kalitesini, depresyonu ve yorgunluk
semptomlarını önemli ölçüde iyileştirdi. [25- (OH) D] düzeyleri düzeyleri 3 ay
sonra belirgin olarak düştü.

Sonuç: D vitamini takviyesi, kas kuvveti,
mobilite, denge kontrolü, depresyon, yorgunluk ve yaşam kalitesi üzerinde
faydalı etkiler göstermiştir. 300.000 IU bolus D vitamini takviyesi erişkin
popülasyonda iyi tolere edilmiştir. D vitamini düzeyinin üç ayda bir
değerlendirilmesini tavsiye ediyoruz. 

Keywords

Denge, Yorgunluk, Kas gücü, Yaşam kalitesi, D vitamini

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