COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı
Drug Use in Pregnant Women Infected with COVID-19

Zeynep TIRMIKÇIOĞLU [1]


Coronavirus ailesi, basit soğuk algınlığından ciddi solunum yolu sendromlarına kadarçeşitli hastalıklara neden olabilen bir virüs ailesidir. Gebelikte Coronavirus enfeksiyonlarını takiben normal ve anormal sonuçlar bildirilmiş olup bebeklerde herhangi bir malformasyon tanımlanmamıştır. 2019 yılında Coronaviruse bağlı yeni bir solunum yolu enfeksiyonu tanımlanmış ve COVID-19 adı verilmiştir. COVID-19’a neden olan virüs ise 2019- nCoV olarak isimlendirilmiştir. COVID-19’un spesifik bir tedavisi bulunmamakla birlikte semptomatik hastaların tedavisinde oseltamivir ve hidroksiklorokin kullanılmaktadır. Pnömonili olgularda antiviral tedaviye azitromisin de eklenebilmektedir. Oseltamivir ve hidroksiklorokine yanıt vermeyen hastalarda, ikinci seçenek tedavi olarak lopinavir/ ritonavir kullanılabilmektedir. Bugüne kadar gebe kadınların COVID-19 enfeksiyonuna daha duyarlı oldukları veya COVID-19 enfeksiyonu olanların daha şiddetli pnömoni geliştirmeye yatkın olduğuna dair bir kanıt yoktur. Klinisyenler anneye ve bebeğe zarar verir miyim düşüncesiyle gebe hastayı tedavi etmekten ve ilaç kullanmaktan çekinebilirler. Aynı zamanda pek çok gebe kadın, tedavinin bebeği için zararlı olabileceğini düşünebilir. COVID-19 tedavisinde kullanılan ilaçlar teratojenik riskleri açısından doğru değerlendirilmelidir. Bu literatür derlemesi, COVID-19 tedavisi için seçilen ilaçların gebelikte kullanımını ve gebelik sonuçlarını sunmaktadır. Olası teratojenik etkilerin değerlendirilmesinden sonra, semptomu olan gebe hastalar da diğer yetişkin bireylere uygulanan ilaçlarla tedavi edilebilir. Enfeksiyonun gebelikte seyri ve kullanılan ilaçların gebelik ve fetus üzerine etkilerinin değerlendirileceği geniş çaplı epidemiyolojik çalışmalara gereksinim vardır. 

Coronaviruses include some of the agents that produce the common cold and some viruses that produce more severe respiratory syndromes. There have been case reports of normal and abnormal pregnancy outcomes after infection with Coronaviruses. Malformations have not been described. A new respiratory tract infection caused by coronaviruses was identified in 2019 and called COVID- 19. The virus causing COVID-19 has been named 2019- nCoV. There is no specific antiviral treatment for COVID-19. Oseltamivir and hydroxychloroquine have been used in the treatment of COVID- 19. In patients with pneumonia, azithromycin has also been used in combination with antiviral treatment. Lopinavir/ ritonavir can be used as second-line treatment for patients not responding to oseltamivir and hydroxychloroquine therapy. As yet, there is no evidence that pregnant women who get COVID-19 are more at risk of serious complications than any other healthy individuals. Clinicians normally hesitate in treating pregnant women by fear of causing damage to both the mother and baby. Meanwhile, many pregnant women think the treatment may be harmful to the baby. Drugs used for COVID-19 should be accurately evaluated for teratogenic risks. This paper presents a literature review regarding pregnancy outcomes after the use of therapeutic agents selected in COVID-19 treatment. After evaluation possible teratogenic effects, symptomatic prengnant patients with COVID-19 can also be treated with drugs used for other adult patients. There is a need for large-scale epidemiological studies in which the course of the infection during pregnancy and the effects of the drugs used on pregnancy and the fetus will be evaluated.

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Primary Language tr
Subjects Health Care Sciences and Services
Journal Section REVİEW
Authors

Orcid: 0000-0002-5639-4665
Author: Zeynep TIRMIKÇIOĞLU (Primary Author)
Institution: İzmir Atatürk Eğitim ve Araştırma Hastanesi
Country: Turkey


Dates

Publication Date : March 20, 2020

Bibtex @review { anadoluklin710736, journal = {Anatolian Clinic the Journal of Medical Sciences}, issn = {2149-5254}, eissn = {2458-8849}, address = {}, publisher = {Hayat Sağlık ve Sosyal Hizmetler Vakfı}, year = {2020}, volume = {25}, pages = {51 - 58}, doi = {10.21673/anadoluklin.710736}, title = {COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı}, key = {cite}, author = {Tırmıkçıoğlu, Zeynep} }
APA Tırmıkçıoğlu, Z . (2020). COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı . Anatolian Clinic the Journal of Medical Sciences , Anatolian Clinic the Journal of Medical Science (Special Issue on COVID 19) , 51-58 . DOI: 10.21673/anadoluklin.710736
MLA Tırmıkçıoğlu, Z . "COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı" . Anatolian Clinic the Journal of Medical Sciences 25 (2020 ): 51-58 <https://dergipark.org.tr/en/pub/anadoluklin/issue/53241/710736>
Chicago Tırmıkçıoğlu, Z . "COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı". Anatolian Clinic the Journal of Medical Sciences 25 (2020 ): 51-58
RIS TY - JOUR T1 - COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı AU - Zeynep Tırmıkçıoğlu Y1 - 2020 PY - 2020 N1 - doi: 10.21673/anadoluklin.710736 DO - 10.21673/anadoluklin.710736 T2 - Anatolian Clinic the Journal of Medical Sciences JF - Journal JO - JOR SP - 51 EP - 58 VL - 25 IS - Special Issue on COVID 19 SN - 2149-5254-2458-8849 M3 - doi: 10.21673/anadoluklin.710736 UR - https://doi.org/10.21673/anadoluklin.710736 Y2 - 2020 ER -
EndNote %0 Anadolu Kliniği Tıp Bilimleri Dergisi COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı %A Zeynep Tırmıkçıoğlu %T COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı %D 2020 %J Anatolian Clinic the Journal of Medical Sciences %P 2149-5254-2458-8849 %V 25 %N Special Issue on COVID 19 %R doi: 10.21673/anadoluklin.710736 %U 10.21673/anadoluklin.710736
ISNAD Tırmıkçıoğlu, Zeynep . "COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı". Anatolian Clinic the Journal of Medical Sciences 25 / Special Issue on COVID 19 (March 2020): 51-58 . https://doi.org/10.21673/anadoluklin.710736
AMA Tırmıkçıoğlu Z . COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı. Anadolu Klin. 2020; 25(Special Issue on COVID 19): 51-58.
Vancouver Tırmıkçıoğlu Z . COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı. Anatolian Clinic the Journal of Medical Sciences. 2020; 25(Special Issue on COVID 19): 51-58.
IEEE Z. Tırmıkçıoğlu , "COVID-19 Enfeksiyonu Olan Gebelerde İlaç Kullanımı", Anatolian Clinic the Journal of Medical Sciences, vol. 25, no. Special Issue on COVID 19, pp. 51-58, Mar. 2020, doi:10.21673/anadoluklin.710736