Süregelen Bir Tartışma: Anjiotensin-Konverting Enzim İnhibitörü ve/veya Anjiotensin Reseptör Blokörü Kullanan Hastaların COVID-19’a Karşı Duyarlılığı Daha Fazla mıdır?

Year 2020, Issue: Special Issue on COVID 19, 79 - 84, 20.03.2020

Sarper Yılmaz Nazif Elaldı Hakan Ertın

https://doi.org/10.21673/anadoluklin.716125

Abstract

Halen içinde olduğumuz beklenmedik Covid-19 pandemisi ile ilgili bilimsel dergilerde konuya ilişkin çok sayıda makale yayımlandı. Bunlardan bir tanesi, halen tedavi görmekte olan hastaların tedavisinde önemli bir değişiklik önermesi nedeniyle özel olarak ele alınmayı hakketmektedir. Bu makalede, Anjiyotensin Konverting Enzim inhibitörleri ile Anjiotensin reseptör blokörü ilaçların hastanın durumunu kötüleştirme riski nedeniyle bırakılması önerilmekteydi. Makalenin Lancet Respiratory Medicine dergisinde yayımlanmasını takiben bilim çevrelerinde hararetli bir tartışma başladı. Burada bu olayı bir olgu şeklinde özetlemeye ve önemli noktaları ilgili bilimsel literatürün ışığında değerlendirmeye çalışacağız

Keywords

Pandemi, Anjiotensin, ACE, ACE2, Coronavirus, Covid-19

An ongoing debate: Are the patients receiving angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers more susceptible to COVID-19 ?

Abstract

As a result of the unprecedented current pandemic, abundant publications about the various aspects of this disease appear in the scientific journals. Among them, one publication deserves special attention because of recommending a substantial change in the management of patients in the current pandemic. This publication recommended the disuse of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers because of the risk of worsening the infection. Immediately following its publication in the Lancet Respiratory Medicine, a vivid discussion emerged in the scientific communities. Herein we will try to summarize this event as a case and mention the important points of the discussion under the light of the relevant literature.

Keywords

Coronavirus, pandemic, angiotensin, ACE, ace2, covid-19

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