A Comparison of the Clinical and Laboratory Characteristics of Influenza A and B Infections in Children

Year 2021, Volume: 26 Issue: 2, 180 - 186, 29.05.2021

Hayrettin Temel , Mehmet Gunduz Gokce Koprulu Sumeyye Karaman Merve Celebi Mehmet Dogan Ayse Tosun Mesut Okur

https://doi.org/10.21673/anadoluklin.836285

Abstract

Aim: In this study, we aimed to compare the clinical and laboratory findings of Influenza A and Influenza B infections in children.

Methods: The study included 1826 pediatric patients (aged <16 years) who were di¬agnosed with Influenza A (n=1400) and B (n=426) infections between 1 October 2019 and 30 April 2020. The patients were also divided into age groups: the age groups of 0–2 years, 3–9 years, and 10–16 years. The characteristic clinical and laboratory findings were compared.

Results: Influenza A infection was significantly more common in patients aged <2 years and was significantly less common in patients aged 3–9 years. Body temperature was significantly higher in all age groups with Influenza A infection than in children with Influenza B infection. While leukocy¬tosis and lymphopenia were significantly more common in the Influenza A group, leukopenia and neutropenia were significantly more common in the Influenza B group. While acute otitis media was more common in Influenza A infection, myositis was more common in Influenza B infection. No significant difference was found between the Influenza A and B groups in terms of hospitalization rates. Of all patients, 98.3% were treated with oseltamivir.

Conclusion: Our findings indicate that Influenza A and B infections are, in general, very similar in terms of symptoms. However, Influenza A infection is more common in very young children. It progresses with higher fever and is more frequently associated with pharyngeal hy¬peremia and acute otitis media, while leukopenia, neutropenia, conjunctivitis, nasal discharge, and myositis were found to be more common in Influenza B infection.

Keywords

Influenza A, influenza B, children

Çocuklarda İnfluenza A ve B Enfeksiyonlarının Klinik ve Laboratuvar Özelliklerinin Karşılaştırılması

Abstract

Amaç: Bu çalışmada, çocuklarda İnfluenza A ve İnfluenza B enfeksiyonlarının klinik ve laboratuvar bulgularını karşılaştırmak amaçlanmıştır.

Yöntem: Çalışma 1 Ekim 2019 ile 30 Nisan 2020 tarihleri arasında İnfluenza A (n=1400) ve B (n=426) enfeksiyonu tanısı almış 16 yaş altı 1826 çocuk hasta içerdi. Hastalar aynı zamanda yaş gruplarına ayrıldı: 0–2 (yıl) yaş grubu, 3–9 yaş grubu, ve 10–16 yaş grubu. Karakteristik klinik bulgu¬lar ve laboratuvar bulguları karşılaştırıldı.

Bulgular: İnfluenza A enfeksiyonu <2 yaşındaki hastalarda anlamlı biçimde daha yaygın, 3–9 ya¬şındaki hastalarda anlamlı biçimde daha enderdi. Vücut sıcaklığı İnfluenza A enfeksiyonlu tüm yaş gruplarında İnfluenza B enfeksiyonlu çocuklara göre anlamlı biçimde daha yüksekti. İnfluenza A grubunda lökositoz ve lenfopeni anlamlı biçimde daha yaygınken, İnfluenza B grubunda lökopeni ve nötropeni anlamlı biçimde daha yaygındı. Akut orta kulak iltihabı İnfluenza A enfeksiyonunda daha yaygınken, miyozit İnfluenza B enfeksiyonunda daha yaygındı. Hastaneye yatış oranı açısından ise İnfluenza A ve B grupları arasında anlamlı fark bulunmadı. Tüm hastaların %98,3’ü oseltamivir ile tedavi edildi.

Sonuç: Bulgularımız İnfluenza A ve B enfeksiyonlarının semptomlar açısından genel olarak çok benzer olduğuna işaret etmektedir. Bununla birlikte, İnfluenza A enfeksiyonu çok küçük çocuklarda daha yaygındır. Daha yüksek ateşle ilerler ve farengeal hiperemi ve akut orta kulak ilti¬habı daha sık görülür. Lökopeni, nötropeni, konjonktivit, burun akıntısı ve miyozitin ise İnfluenza B enfeksiyonunda daha yaygın olduğu tespit edilmiştir.

Keywords

Influenza A, influenza B, çocuklar

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