Varisella zoster virüs tanısında kullanılan varisella zoster virüs IgM, IgG ve avidite sonuçlarının değerlendirilmesi

Year 2025, Volume: 30 Issue: 2, 185 - 190, 29.05.2025

Emel Çalışkan

https://doi.org/10.21673/anadoluklin.1641218

Abstract

Amaç: Varisella zoster virüs (VZV), solunum yoluyla hızlı şekilde bulaşan ve dünya genelinde seroprevalansı yüksek olan bir hastalıktır. Bu çalışmada laboratuvarımızda çalışılan VZV IgM, VZV IgG ve VZV avidite serolojik testlerinin sonuçlarının değerlendirilmesi amaçlanmıştır.

Yöntemler: Çalışmada, Kasım 2019-Aralık 2024 tarihleri arasında laboratuvarımıza suçiçeği ön tanısı ya da tarama amacıyla gönderilen serum örneklerinde çalışılan VZV IgM, VZV IgG ve VZV avidite test sonuçları retrospektif olarak incelendi. Sonuçların yaş ortalamalarına, cinsiyete ve yıllara göre değerlendirilmesinde Kruskal-Wallis ve Ki-Kare testleri kullanıldı.

Bulgular: Çalışmada, VZV IgG pozitifliği %88,5 (2721/3074), VZV IgM pozitifliği %5,2 (51/990) olarak saptanmıştır. Doğurganlık çağındaki kadınlarda VZV IgG negatifliği %7,8 (122/1569), 65 yaş üstü yaşlı bireylerde de bu oran %7 (4/57) olarak saptanmıştır. IgG ile IgM istemi birlikte yapılıp her ikisi de pozitif saptanan 29 örneğin sadece üçünde avidite testi çalışılmış ve yüksek avidite olarak bulunmuştur. Düşük avidite sonucu saptanmamıştır. VZV IgM ve VZV IgG sonucu pozitif, negatif ya da ara değer saptanan hastalar arasında cinsiyete ve yaş ortalamalarına göre istatistiksel olarak anlamlı fark saptanmamıştır. Ayrıca yıllar arasında da VZV IgM ve VZV IgG sonuçları açısından istatistiksel olarak anlamlı fark saptanmamıştır.

Sonuç: VZV IgG pozitifliği yüksek olmakla birlikte, riskli gruplarda VZV IgG ile antikor taramasının yapılması önerilebilmektedir. Ayrıca VZV avidite testinin laboratuvarlarda refleks test olarak çalışılmasının uygun olabileceği düşünülmüştür.

Keywords

Avidite, immünglobulin M, varisella-zoster virüsü

Evaluation of varicella zoster virus IgM, IgG and avidity results used in the diagnosis of varicella zoster virus

Abstract

Aim: Varicella zoster virus (VZV) is a disease that is rapidly transmitted through the respiratory tract and has a high seroprevalence worldwide. This study aimed to evaluate the results of VZV IgM, VZV IgG and VZV avidity serological tests studied in our laboratory.

Methods: In this study, the VZV IgM, VZV IgG, and VZV avidity test results in serum samples sent to our laboratory for preliminary diagnosis or screening of chickenpox between November 2019 and December 2024 were retrospectively examined. Kruskal-Wallis and Chi-Square tests were used to evaluate the results according to mean age, gender, and years.

Results: In this study, VZV IgG positivity was found to be 88.5% (2721/3074) and VZV IgM positivity was found to be 5.2% (51/990). VZV IgG negativity was found to be 7.8% (122/1569) in females of childbearing age, and 7% (4/57) in elderly individuals over 65 years of age. In only three of the 29 samples in which both IgG and IgM were requested and both were found positive, the avidity test was performed and found to be high avidity. No low avidity result was detected. No statistical significant difference was detected between the patients whose VZV IgM and VZV IgG results were positive, negative or borderline values according to gender and age means. In addition, no statistical significant difference was detected between the years in terms of VZV IgM and VZV IgG results.

Conclusion: Despite the high positivity of VZV IgG, antibody screening with VZV IgG can be recommended for high-risk groups. In addition, it was considered appropriate to study the VZV avidity test as a reflex test in laboratories.

Keywords

Avidity, immunoglobulin M, varicella-zoster virus

Supporting Institution

bulunmamaktadır.

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