ajps

Anatolian Journal of Pharmaceutical Sciences

2980-0463

Inonu University

10.71133/anatphar.1791675

Biochemistry and Cell Biology (Other)

Biyokimya ve Hücre Biyolojisi (Diğer)

Examination Of The Protective Efficiency Of The Fruit Extract And Fruit Vinegar Of The Hawthorn (Crataegus Tanacetifolia) Plant Against Hyperlipidemia And Possible Endothelial Damage In An Experimentally Induced Model Of Hyperlipidemia In Rats

https://orcid.org/0009-0009-7981-953X

Çetin

Celalettin Rahman

İNÖNÜ ÜNİVERSİTESİ

https://orcid.org/0000-0002-7407-2352

Çankaya

Özlem

İnönü Üniversitesi Yılmaztekin

Yakup

İNÖNÜ ÜNİVERSİTESİ

https://orcid.org/0000-0001-9517-9274

Uyumlu

Ayşe Burçin

İNÖNÜ ÜNİVERSİTESİ

https://orcid.org/0000-0002-2538-5774

Satılmış

Basri

İNÖNÜ ÜNİVERSİTESİ

https://orcid.org/0000-0001-8680-3098

Yılmaz

İsmet

İNÖNÜ ÜNİVERSİTESİ

https://orcid.org/0000-0002-6244-0517

Genç

Metin

İNÖNÜ ÜNİVERSİTESİ

https://orcid.org/0000-0001-6663-2287

Batçıoğlu

Kadir

İNÖNÜ ÜNİVERSİTESİ

12 19 2025

4 3 150 165 09 26 2025 11 14 2025

2022

Anatolian Journal of Pharmaceutical Sciences

Atherosclerosis is one of the leading causes of death in humans worldwide. Hyperlipidaemia is a significant risk factor for atherosclerosis and is characterised by accelerated atherosclerosis. However, factors such as homocysteine, adhesion molecules, and low HDL-C levels have been reported to play a role in the development of atherosclerosis and hyperlipidaemia. This study aimed to investigate the effects of hawthorn (Crataegus tanacetifolia) fruit extract and fruit vinegar on total cholesterol (TC), triglycerides (TG), Nitrit (NOx), HDL-C, LDL-C, homocysteine, P-selectin, and VCAM-1 levels, which are among the factors causing hyperlipidaemia and atherosclerosis. In the study, hawthorn extract (HE) and hawthorn vinegar (HV) were administered by gavage to rats with experimentally induced hyperlipidaemia (HL). Rats were divided into seven groups. The control group was fed a normal diet. Blood samples taken at the beginning of the study and the end of the fourth and eighth weeks were separated, and the levels of TC, TG, NOx, HDL-C, LDL-C, homocysteine, P-selectin, and VCAM-1 were measured. Our results showed that adding HE or HV to the diet reduced homocysteine, P-selectin, TC, LDL-C, NOx and TG levels and increased HDL-C levels. In conclusion, the results of this study, in which we hypothesised that hawthorn fruit extract and fruit vinegar may reduce the risk of atherosclerosis, which increases in correlation with hyperlipidaemia, hypercholesterolaemia, hyperhomocysteinemia and increased levels of adhesion molecules caused by a high-fat diet, showed that hawthorn fruit extract had a strong antiatherogenic effect

Hawthorn Hawthorn vinegar Crataegus tanacetifolia Hyperlipidaemia Atherosclerosis

Inonu Univertsity

2011/148

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