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Agresif fibromatozis: Prognostik faktörler ve cerrahi tedavi sonuçlarının değerlendirilmesi

Year 2014, Volume: 48 Issue: 1, 55 - 60, 17.03.2014

Levent Kucuk Burcin Kececi Dundar Sabah Guven Yuceturk

Abstract

Amaç: Çalışmamızın amacı agresif fibromatozisin cerrahi tedavisinin sonuçları ile nüks prognostik faktörlerin nüks gelişimi üzerine etkilerini değerlendirmekti.
Çalışma planı: Agresif fibromatozis tanısı alan 40 hasta (24 kadın, 16 erkek; ortalama yaş: 31.2) retrospektif olarak değerlendirildi. Cerrahi sınırlarda makroskobik olarak pozitif tümör dokusu saptanan 9 hasta çalışma dışında bırakıldı. Çalışmada, yaş, cinsiyet, tümör yerleşimi, hastanın kliniğe başvurduğu andaki durumu, kompartman durumu, cerrahi sınır, tümör boyu ve adjuvan radyoterapi gibi prognostik faktörler değerlendirildi.
Bulgular: Nüks oranı %29 olarak saptandı. Ortalama hastalıksız takip süresi 46±4 aydı. Nüks gelişimi ile prognostik faktörler arasında istatistiksel olarak anlamlı bir sonuç yoktu. Adjuvan radyoterapi uygulanan hastalardaki klinik sonuçların daha tatmin edici olduğu görüldü.
Çıkarımlar: Fonksiyonun feda edilerek geniş cerrahi sınırların sağlanması yerine adjuvan radyoterapi uygulaması agresif fibromatozis tedavisi için akılcı bir yaklaşım olacaktır.

Keywords

Adjuvan radyoterapi; ekstremite koruma; nüks; sağkalım

References

  • Dalén BP, Bergh PM, Gunterberg BU. Desmoid tumors: a clinical review of 30 patients with more than 20 years’ follow-up. Acta Orthop Scand 2003;74:455-9.
  • Yücetürk G, Sabah D, Keçeci B, Kara AD, Yalçinkaya S. Prevalence of bone and soft tissue tumors. Acta Orthop Traumatol Turc 2011;45:135-43.
  • Goy BW, Lee SP, Eilber F, Dorey F, Eckardt J, Fu YS, et al. The role of adjuvant radiotherapy in the treatment of resectable desmoid tumors. Int J Radiat Oncol Biol Phys 1997;39:659-65.
  • Hoffmann W, Weidmann B, Schmidberger H, Niederle N, Seeber S, Bamberg M. The clinical picture and therapy of aggressive fibromatosis (desmoids). [Article in German] Strahlenther Onkol 1993;169:235-41. [Abstract]
  • Kirschner MJ, Sauer R. The role of radiotherapy in the treatment of desmoid tumors. Strahlenther Onkol 1993;169:77-82.
  • Nakada I, Ubukata H, Goto Y, Watanabe Y, Sato S, Tabuchi T, et al. Prednisolone therapy for intra-abdominal desmoid tumors in a patient with familial adenomatous polyposis. J Gastroenterol 1997;32:255-9.
  • Sİrensen A, Keller J, Nielsen OS, Jensen OM. Treatment of aggressive fibromatosis: a retrospective study of 72 patients followed for 1-27 years. Acta Orthop Scand Alaggio R, et al. Aggressive fibromatosis in children and adolescents: the Italian experience. Cancer 2010;116:233
  • Kamath SS, Parsons JT, Marcus RB, Zlotecki RA, Scarborough MT. Radiotherapy for local control of aggressive fibromatosis. Int J Radiat Oncol Biol Phys 1996;36:325-8. McCollough WM, Parsons JT, van der Griend R, Enneking WF, Heare T. Radiation therapy for aggressive fibromatosis. The Experience at the University of Florida. J

Aggressive fibromatosis: evaluation of prognostic factors and outcomes of surgical treatment

Year 2014, Volume: 48 Issue: 1, 55 - 60, 17.03.2014

Levent Kucuk Burcin Kececi Dundar Sabah Guven Yuceturk

Abstract

Objective: The aim of this study was to evaluate the results of surgical treatment of aggressive fibromatosis and the effects of prognostic factors on recurrence.
Methods: Forty patients (24 female, 16 male; average age: 31.2 years) diagnosed with aggressive fibromatosis were evaluated retrospectively. Nine patients with tumor-positive surgical margins macroscopically were excluded. Prognostic factors such as age, gender, localization, admission status, compartment status, surgical margin, tumor size and adjuvant radiotherapy were evaluated.
Results: Recurrence rate was 29%. Average disease free survival was 46±4 months. There was no statistically significant relation between prognostic factors and recurrence. Clinical results of the patients receiving adjuvant radiotherapy were more satisfactory.
Conclusion: Adjuvant radiotherapy administration appears to be a rational treatment method instead of sacrificing function to achieve wide surgical margins.

Keywords

Adjuvant radiotherapy limb salvage recurrence survival

References

  • Dalén BP, Bergh PM, Gunterberg BU. Desmoid tumors: a clinical review of 30 patients with more than 20 years’ follow-up. Acta Orthop Scand 2003;74:455-9.
  • Yücetürk G, Sabah D, Keçeci B, Kara AD, Yalçinkaya S. Prevalence of bone and soft tissue tumors. Acta Orthop Traumatol Turc 2011;45:135-43.
  • Goy BW, Lee SP, Eilber F, Dorey F, Eckardt J, Fu YS, et al. The role of adjuvant radiotherapy in the treatment of resectable desmoid tumors. Int J Radiat Oncol Biol Phys 1997;39:659-65.
  • Hoffmann W, Weidmann B, Schmidberger H, Niederle N, Seeber S, Bamberg M. The clinical picture and therapy of aggressive fibromatosis (desmoids). [Article in German] Strahlenther Onkol 1993;169:235-41. [Abstract]
  • Kirschner MJ, Sauer R. The role of radiotherapy in the treatment of desmoid tumors. Strahlenther Onkol 1993;169:77-82.
  • Nakada I, Ubukata H, Goto Y, Watanabe Y, Sato S, Tabuchi T, et al. Prednisolone therapy for intra-abdominal desmoid tumors in a patient with familial adenomatous polyposis. J Gastroenterol 1997;32:255-9.
  • Sİrensen A, Keller J, Nielsen OS, Jensen OM. Treatment of aggressive fibromatosis: a retrospective study of 72 patients followed for 1-27 years. Acta Orthop Scand Alaggio R, et al. Aggressive fibromatosis in children and adolescents: the Italian experience. Cancer 2010;116:233
  • Kamath SS, Parsons JT, Marcus RB, Zlotecki RA, Scarborough MT. Radiotherapy for local control of aggressive fibromatosis. Int J Radiat Oncol Biol Phys 1996;36:325-8. McCollough WM, Parsons JT, van der Griend R, Enneking WF, Heare T. Radiation therapy for aggressive fibromatosis. The Experience at the University of Florida. J
There are 8 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Levent Kucuk This is me

Burcin Kececi This is me

Dundar Sabah This is me

Guven Yuceturk This is me

Publication Date March 17, 2014
Published in Issue Year 2014 Volume: 48 Issue: 1

Cite

APA Kucuk, L., Kececi, B., Sabah, D., Yuceturk, G. (2014). Aggressive fibromatosis: evaluation of prognostic factors and outcomes of surgical treatment. Acta Orthopaedica Et Traumatologica Turcica, 48(1), 55-60.
AMA Kucuk L, Kececi B, Sabah D, Yuceturk G. Aggressive fibromatosis: evaluation of prognostic factors and outcomes of surgical treatment. Acta Orthopaedica et Traumatologica Turcica. March 2014;48(1):55-60.
Chicago Kucuk, Levent, Burcin Kececi, Dundar Sabah, and Guven Yuceturk. “Aggressive Fibromatosis: Evaluation of Prognostic Factors and Outcomes of Surgical Treatment”. Acta Orthopaedica Et Traumatologica Turcica 48, no. 1 (March 2014): 55-60.
EndNote Kucuk L, Kececi B, Sabah D, Yuceturk G (March 1, 2014) Aggressive fibromatosis: evaluation of prognostic factors and outcomes of surgical treatment. Acta Orthopaedica et Traumatologica Turcica 48 1 55–60.
IEEE L. Kucuk, B. Kececi, D. Sabah, and G. Yuceturk, “Aggressive fibromatosis: evaluation of prognostic factors and outcomes of surgical treatment”, Acta Orthopaedica et Traumatologica Turcica, vol. 48, no. 1, pp. 55–60, 2014.
ISNAD Kucuk, Levent et al. “Aggressive Fibromatosis: Evaluation of Prognostic Factors and Outcomes of Surgical Treatment”. Acta Orthopaedica et Traumatologica Turcica 48/1 (March 2014), 55-60.
JAMA Kucuk L, Kececi B, Sabah D, Yuceturk G. Aggressive fibromatosis: evaluation of prognostic factors and outcomes of surgical treatment. Acta Orthopaedica et Traumatologica Turcica. 2014;48:55–60.
MLA Kucuk, Levent et al. “Aggressive Fibromatosis: Evaluation of Prognostic Factors and Outcomes of Surgical Treatment”. Acta Orthopaedica Et Traumatologica Turcica, vol. 48, no. 1, 2014, pp. 55-60.
Vancouver Kucuk L, Kececi B, Sabah D, Yuceturk G. Aggressive fibromatosis: evaluation of prognostic factors and outcomes of surgical treatment. Acta Orthopaedica et Traumatologica Turcica. 2014;48(1):55-60.